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Human INFANTS heavy-chain variable regions after immunization with Hib-PS-conjugate .EP16 ..1 qvqlqqwgagllkpsetlslt c avy gg sfsgyyws w irqppgkglewigeinhsgstnyn ..RL1 ..1 EVQLVESGGGLVQPGGSLRLS C AAS GF TFSNYWMN W VRQAPGKGLEWVAKIKQDGSDKYY .MAX1 ..1 QVQLVESGGGVVQPGRSLRLS C AAS GF TFSSYGMH W VRQAPGKGLEWVAVIWYDGSNKYY MMM14 ..1 EVQLLESGGGLVQPGGSLRLS C AAS GF TFSSYAMS W VRQAPGKGLEWVSAISGSGGSTYY .MAX4 ..1 EVQLVESGGGLVKPGGSLRLS C AAS GF TFSSYSMN W VRQAPGKGLEWVSSISSSSSYIYY .MAX6 ..1 EVQLVESGGGLVQPGGSLRLS C AAS GF TFSSYSMN W VRQAPGKGLEWVSYISSSSSTIYY .MAX6' .1 EVQLLESGGGLVQPGGSLRLS C AAS GF TFSSYAMS W VRQPPGKGLEWVSAISGSGGSTYY MMM4.1 .1 EVQLLESGGGLVQPGGSLRLS C AAS GF TFSSYAMS W VRQAPGKGLEWVSAISGSGGSTYY .EP16 .61 p-slksrvtisvdtsknqfslklssvtaadtavyy c argrrsswlkpyyyyyymdv ..RL1 .61 vdsvkgrftisrdnnenslflqmnslraedtavyy c arasagpysgstd .MAX1 .61 adsvkgrftisrdnskntlylqmnslraedtavyy c argfravyssswyvllngmdv MMM1.4 61 adsvkgrftisrdnskntlylqmnslraedtavyy c akllkkgiavagtd .MAX4 .61 adsvkgrftisrdnaknslylqmnslraedtavyy c ardgagllgtsyydiltgyyftgstak yyyygmdv .MAX6 .61 adsvkgrftisrdnaknslylqmnslrdedtavyy c arapgyssswytlggdyyyyyygmdv .MAX6'.61 adsvkgrftisrdnskntlylqmnslraedtavyy c antpacyyygsgsypryyyygidv MMM4.1 61 adsvkgrftisrdnskntlylqmnslraedtavyy c akllkkgiavagtd Ig heavy-chain variable regions mouse .1 .............EVQLQESGPDLVKPGASMKIP C KAS GY TFTDYNMD W VKQSHGKSLEWIGDINPNNGGAIY... mouse .1 .............DVHLQESGPGLVAPSQTLSIT C TVS GF SLTNYGIH W VRQPPGKGLEWLGVMWAGGNSNYN... Mouse anti-DNA immunoglobulin heavy-chains (variable region) IgG2A .1 ............. QVQLQQPGAELVKPGASVKLS C KAS GY TFTRYWMH W VKQRPGQGLEWIGEIDPSDSYTYYNQKFKGKAT 10CH . 1 .............. VQLQESGPELVRPGVSVKIS C KGS GY TFTDYPMH W VKQSHAKSLEWIGVISTYYGNTNYN IgG3 . 1 ..................... PVLEAPSQSLSIT C TVS GF SLTSYGVH W VRQPPGKGLEWLGVIWAGGSTNYNSALMSRLS 10F4 . 1 ..................... PELVKPGASVKMS C KAS GY TFISYVMH W VKQKPGQGLEWIGYINPYNEGTKYNEKFKGKA 10CK . 1 ............ diqmtqspaslsasvgetvtit c ras en --iysyla w yqqkqgkspqvlvynakdlaegvps 10VH . 1 .............. VQLQESGPELVRPGVSVKIS C KGS GY TFTDYPMH W VKQSHAKSLEWIGVISTYYGNTNYN 10VL . 1 ............ diqmtqspaslsasvgetvtit c ras en --iysyla w yqqkqgkspqvlvynakdlaegvps IgG2A 70 ........ ltvdkssstaymqlssltsedsavyy c ak grl--ry----yamd ywgqgtsvtvss 10CH .61 .rnfkgkatmtvdkssstaymelarltsedsaiyy c ar lnld-gyy-gf---a ywgqgtlvtvsaa IgG3 .61 ........ iskdnsksqvflkmnslqtddtamyy c ak hlpy-gny-gyyamdywgqgtsvtvss 10F4 .61 ....... tltsdkssstaymelssltsedsavyy c ar srtp-ayysnypwfaywgqgtlvtvsa 10CK .61 ....... rfsgsgagtqfslrinslqpedfgsyy c qh hy---gt----p-l-tfgagtelelrradaaptvsifpp 10VH .61 .rnfkgkatmtvdkssstaymelarltsedsaiyy c ar lnld-gyy-gf---a ywgqgttvtvss 10VL .61 ....... rfsgsgagtqfslrinslqpedfgsyy c qh hy---gt----p-l-tfgagtklelkr 10CH 121 .......KTTAPSVYPLAPV C GDTTGSSVTLG C LVK GY FPEPVTLT W NSGSLSSGVHTFPAVLQSDL 10CK 121 .................... sseqltsggasvv c fln nf ypkdinvk w kidgserqngvlnswtdqdskdstysmsstlt 10CH 181 ..............ytlsssvtvtsstwpsqsit c nvahpasstkvdkkie 10CK 181 .................... ltrdeyerhnsyt c eathktstspivksfnrne Mouse Immunoglobulin heavy chains 10.1 ....1 ..............EVQLQQSGAELVKPGASVKLS C APS GF NIKDTYMH W VYQRPEQCLEWIGKIDPANGNTEY 12.1.A ..1 ..............EVQLQQSGAELVKPGASVKLS C APS GF NIKDTYMH W VYQRPEQGLEWIGKIDPANGNTEY 12.1.B ..1 ..............EVQLQQSGAELVKPGASVKLS C APS GF NIKDTYMH W V... 18.1 ....1 ..............EVQLQQSGAELVKPGASVKLS C APS GF NIKDTYMH W VYQRPEQGLEWIGKIDPANGNTEY 20.1 ....1 ..............EVQLQQSGAELVKPGASVKLS C APS GF NIKDTYIH W VYQRPEQGLEWIGKIDPANGNTEY 20.1.A ..1 ..............EVQLQQSGAELVKPGASVNLS C APS GF NIKDTYMH W V... 20.1.F ..1 ..............EVQLQQSGAELVKPGASGNLS C APS GF NIKDTYMH W VYQRPEQGLEWIGKIDPANGNTES 22.22.2 .1 ..............EVQLQQSGAELVKPGASVKLS C APS GF NIKDTYMH W VWQRPEQGLEWIGKIDPANGNTEY 10.1 ...61 DPKFQGKATITADTSSNTAYLQLSSLTSEHTAVYY C TGG GY FGSRSYWYFDVWGAGTTVTVSS 12.1.A .61 DPKFQGKATITADTSSNTAYLQLSSLTSEHTAVYY C TGG GY FGSRSYWYFDVWGAGTTVTVSS 18.1 ...61 DPKFQGKATITADTSSNTAYLQLSSLTSEHTAVYY C TGG GY FGSRSYWYFDVWGAGTTVTVSS 20.1 ...61 DPKFQGKATITADTSSNTAYLQLSSLTSEHTAVYY C TGG GY FGSRSYWYFDVWGAGTTVTVSS 20.1.F .61 DPKFQGKATITADTSSNTAYLQLSRLTSEHTAVYY C TGG GY FGSRSYWYFDVWGAGTTVTVSS 22.22.2 61 DPKFQGKATITADTSSNTAYLQLSSLTSEHTAVYY C TGG GY FGSRSYWYFDVWGAGTTVTVSS Human immunoglobulin Variable Heavy chain .VH3 .1 ...................QLQLVESGGGVVQPGRSLRLS C AAS GF SFSGYGMH W VRQAPGKGLEWVALIGLDASNTYY .VH3 .1 ...................EVQLLQSGGGLIQPGGSLRLS C TAS GF TFNSFAMS W VRQAPGKGLEWVSTISRSGHTTYF .VH6 .1 ...................qvqlqqsgpglvkpsqtlslt c avs gd svasnnaa w hwirqspsrglewlgrtyyrsrwy .VH4 .1 ...................qlqlqesgpglvkppetlslt c tvs gg sirsssyy w gwirqppgkglewigtiyysgstf T1-2 .1 ...............gvlsqvqlqqwgagllkpsetlslt c avy gg sfs-gy-y w swirqpagkglewigriytsgs T1-5 .1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsqtlslt c tvs gg sissgsyy w swirqpagkglewigriytsgs MonG .1 ...................qvqlqesgpglvkpsetlslt c tvs ga sisshyws w irqpqgrglewigyiyssgstdsn .VH3 61 .....adsvkgrytisrdnskstlylqmnslrvddtalyy c vrenfpgfwsgrmdvwgqgttvtvss .VH3 61 .....adsvkgrftisrdnpkntlylqmnslrvedtaiyy c akvsgvvapaaldvwgqgttvtvss .VH6 61 ..hdyapsvksrinidpdssknqfslqlnsvtpedtavyf c ataalsysstwhnyfdpwghgt .VH4 61 ....ynpslksrvtisvdtsknqfslklssvtaadtavyy c arqvgyndyfdafdiwgqgtmvtvss T1-2 61 t..nynpslksrvtmsvdtsknqfslklssvtaadtavyy c ardtvrggeceprk T1-5 61 ..tnynpslksrvtisvdtsknqfslklssvtaadtavyy c ardtvrg MonG 81 ......pslksrvtisvdtsknqlslkltsvtaadtavyy c treatdyeswsdyyrwfdawgqgslvtvss Rabbit mu heavy-chain ----------FR1----------------------HV1---------------FR2---------- N6 ...1 qqleqsgggaggglvkpggslelc c kas gf slsssy wic wvhqapgkglewigciyagsg N55 ..1 ...qeqlvesggglvtpgeslklc c kas gf t-tsny ymc wvrqapgkglewigciyagsg N59 ..1 qqlkqsgggaggglvkpggslelw c kas gf sfs-cy ymc wvrqapgkglewigciyagsgg N65 ..1 qqleqsgggaggglvkpggslelc c kas gf tfs-sy ymc wvrqapgkglewivciydgsrg N101 .1 qqleqsgggaggglvkpggslelc c kas gf iisssy wic wvrqapgkglewigcivagss N103 .1 qqleqsgggaggglvkpggslelc c kas gf slnssy wic wvrqapgkglewigcissggs N104 .1 ....qsveesggglvtpggilslt c tvs gf slss-y gvi wvrqapgnglewigiigsygttyyas N108 .1 qqleqsgggaggglvkpggslelc c kas gf tisssy wmc wvrqapgkglewirciyagsg N113 .1 ....qsveesrgdlikptdtltlt c tvs gf slss-y ait wvrqapgnglewigyisvggsayyas N115 .1 ....qsleesggglvkpggsltlt c tvs gf slssne is- wvrqapgkeldwigtitsggftyyas N116 .1 qqleqsgggaggglvkpggslelc c kas gf tfss-y wic wvrqapgkglewngciytggsa N119 .1 qqleqsgggaggglvktggslelc c kas gf slss-y ymc wvrqapgkglewigciyaggsg N120 .1 qqleqsgggaggglvkpggslelc c kas gf slss-y smc wvrlapgkglewigciaagssg N124 .1 ...qeqlkesggglvqpggslkls c kas gf dlss-y yms wirqapgkglewigiiyagssstdy N125 .1 ....qsveesggglvqpggslilt c tas gi yfss-y gms wvrqapgkglewigfinigsggtyya N127 .1 qqleqsgggaggglvkpgeslelc c kas gf slsssy wic wvrqapgkglewigciyagss N128 .1 qqleqsgggaggglvkpggslelc c kas rf slsssy wic wvrqapgkglewigciyvgsg N205 .1 qqleqsgggaggglvkpggslelc c kas gf tistsy wmc wvrqapgkglewigciydgss N206 .1 ....qsleksrgglikpggtltlt c tas gf tist-y ais wvrqapgkelewigaistggstdyar N210'.1 ....qsleksrgglikpggtltlt c tas gf tist-y ais wvrqapgkelewigaistggstdyar N210 .1 qqleqsgggaggglvkpggslelc c kas gf slsssy -mc wvrqapgkglewigciyagsrg N214 .1 ...qeqlkesggglvqpggslklf c kas gf dfss-y wms wvrqapgkglewigciyggssgsty N217 .1 qwleqsgggaggglvkpggslelc c kas gf sfsssy wic wvrqapgkglewigciyggss N220 .1 qqleqsgggaggglvkpggslelc c kas gf slsssy -mc wvrqapgkglewigciyagssg N221 .1 ...qeqlkesggglitpggtltlt c tas gf tist-y rmg wvrqapgkgldyigyirdggsayya N223 .1 qqleqsgggaggglvkpggslelc c kas gf slsssy wic wvrqtpgkglewigciyagss N224 .1 qqleqsgggaggglvkpggslelc c kas gf slssny wic wvrqapgkglewieciyagss N226 .1 ....qsvkesegglfkptdtltlt c tvs gf slss-y ais wvrqapgkglewigyiytdgsayyas N227 .1 qqleqsgggaggglvkpggslelc c kas ef slsssy wic wvhqapgkglewigciyagsr N228 .1 ....qsleesggglvtpggtltlt c tas gf tiss-y ais wvrqapgkelewigyiyisgntyyan N229 .1 qqleqsgggaggglvkpggslelc c kas gf slsssy wic wvrqapgkglewigciyagsr N232 .1 qqleqsgggaggglvkpggslelc c kas gf tfss-y ymc wvrqapgkglewivciydgsrg N236 .1 ...qeqlkesggglvqpggslkls c kas gf dfss-y wms wvrqapgkglewigciyvgssgsty N237 .1 qqleqsgggaggglvkpggslelc c kas gf sltssy wic wvrqapgkglewigciyagkg N240 .1 qqleqsgggaggglvkpggslelc c kas gf slsssy -mc wvrqapgkglewigciyagssg N246 .1 qqleqseggaggglvkpggslelc c kas gf sls-ny ymc wvrqapgkglewfgciyggsgg. ---------------------------------FR3------------------- ------HV3------- ------FR4------------ N6 ..61 .styyaswvngrftlsrdidqstgclqlnsltaadtatyy c ar dy-pgs------tayn mwgp N55 .57 sstyyaswvngrftlsrdndqstgclqlnsltaadtamyy c ar ggvpg--gf---yyyn iwgpgtlvtvssv N59 .61 .rtyyaswvngrftlsrdidqstgclqlnsltaadtamyy y ar gs-----------wyd fwgp N65 .61 .ntyyaswvngrftlsrdidqstgclqlnsltvadtamyy c ar sds-g -gy--g-y-a iwgpgtlvtvssv N101 61 gstyyaswvngrftisrdidqstgclqlnsltaadtamyc c ar gas-gs-dyi-gnyfn iwgp N103 61 ..tyyaswvngrfnlsrdidqstgclqlnsltaadtaiyy c ar dt--gs-sw----yfn iwgp N104 61 .......waksrstitrntnlntvplkmtsltaadtatyf c ar gryvgs-sy--gdyfn iwgp N108 61 gttyyaswvngrftlsrdidqstgclqlnsltaadtamyy c ar gdyyss-gw--ggyfs iwgp N113 61 .......wakgrstitrntnentvtlkmtsltaadtatyf c ar dyaat----------- iwgp N115 61 .......raksrstitrntnentvtlkmtsltaadtatyf c as enpryp-gyssgtlln iwgp N116 61 ...yyaswaksrstitrntnentvtlkmtsltaadtatyf c ar -------gw---ayfs iwgp N119 61 .styyaswvngrftlsrdidqstgclelnsltvadtamyy c ar ----g--gadi-wyfd iwgp N120 61 .styyaswvngrftlsrdidqstgclqlnsltaadtamyy c ar -------swsityyfd iwgp N124 61 .....aswvngrftissdnaqntvdlqmnnltaadtatyf c ar grygss-syykryyfn iwgpgtlvtvssv N125 61 ......swvngrftitrntnentvtlnmtsltaadtatyf c ar ldp----gyssgg--- iwgp N127 61 dstayaswvngrftlsrdidqstgclqlnsltaadtamyh c ar a-p----gw--ggafn pwgp N128 61 gstyyaswvngrftlsrdidqstgclqlnsltaadtamyy c ar dllv---g-------d iwgp N205 61 gstdyaswvngrftlsrdidqstgclqlnsltaadtamyy s ar arda-------gssfg iwgp N206 61 .......waksrstitrntnentvtlkmtsltaadtatyf c ak --------wspddafd pwgp N210 61 .styyaswvngrftlsrdidqstgclqlnsltvadtamyy c tr -------g-issgasd iwgp N210'61 .......waksrstitrntnentvtlkmtsltaadtatyf c ak --------wspddafd pwgp N214 61 ....yaswvngrftlsrdidqstgclqlnsltaadtaiyy c ar -n-r------i--ffn iwgpgtlvtvssv N217 61 gnsyyaswvngrftlsrdidqstgclqlnslttadtaiyy c ar dkkyyiygwgygtgmd iwgpgtlvtvssv N220 61 .styyaswvngrftlsrdidqstgclqlksltaadtamyy c as -ny-------agss-- ywgp N221 61 ......swaksrstitrntnentvtlkmtsltaadtatyf c ar -------g-gfangkd pwgpgtlvtvssv N223 61 gstyyaswvngrftlsrdidqstgclqlssltvadtalyy c ar dv-----gasp-dafd pwgp N224 61 gstyyaswvngrftlsrdidqstgclqlnsltaadtamyy c ar -------gdyavssyp iwgpgtlvtvssv N226 61 .......waksrstitrntnentvtlkmtsltaadtatyf c ar ---------gwv-gln iwgpgtlvtvssv N227 61 gntfyaswvngrftlsrdidqstgclqlnsltvadtamyy c ar vadssstgvydv--fd pwgp N228 61 .......waksrstvtrntnentvtlkmtsltaadtatyf c ar ----------ggagsn iwgp N229 61 vityyaswvngrftlsrdidqstgclqlnsltvadtamyf c ar ----yv---dgyyytn iwgpgtlvtvssv N232 61 .ntyyaswvngrftlsrdidqstgclqlnsltvadtamyy c ar ----s---dsggygya iwgpgtlvtvssv N236 61 ....yaswvngrftlsrdidqstgclqlnsltvadtamyy c ar gs------ygynyald iwgp N237 61 dntyyaswvngrftlsrdidqstgclqlnsltaadtatyf c ar gls-----ysygyald iwgp N240 61 .stayaswvngrftisrdndqstgclqlnsltvadttmyy c ar --r-----dagsghyn iwgp N246 61 .styyaswvngrftlsrdidqstgclqlnsltaadtamyy y ak tv-------gsytvfn iwgp P20 ..1 ....qsveesrgglikptdtlilt c tas gf tissysig-wvrqapgkglewigtigsygstyyas P21 ..1 ....qsveesrgglikptdtltlt c tvs gf slssyais-wvrqapgngleyigtigttgntyyas P29 ..1 ....qsvkesegglfkptdtltlt c tvs gf slssygvi-wvrqapgngleyigtitgagnalyas P30 ..1 qqleqsgggagggqvkpggslelc c kas gf tfssyywicwvrqapgkglewigciyagss P101 .1 ....qsveesrgglikptdtltlt c tvs gf slssygvi-wvrqapgngleyigwisasgntyyan P102 .1 ....qsleesrgglfkptdtltlt c tvs gf slssyais-wvrqapgngleyigtilssgsayyas P103 .1 ....qsvkesegglfkptdtltlt c tvs gf slssygvi-wvrqapgngleyigtitgagnalyas P104 .1 ....qsvkesegglfkptdtltlt c tvs gf slssyais-wvrqapgnglewigtigsdgstyyas P105 .1 ....qsvkesegglfkptdtltlt c tvs gf slssygvi-wvrqapgngleyigminsygstyyas P107 .1 ....qsveesrgglikptdtltlt c tvs gf slssygvi-wvrqapgegleyigiintggsayyas P109 .1 ....qsveesrgglikptdtltlt c tvs gf slssygvi-wvrqapgngleyigtigssgsayyas P110 .1 ...qeqlkesggglvqpggslkls c kas gf dfssywms-wvrqapgkglewigciyvgssgsty P111 .1 ....qsvkesegglfkptdtltlt c tvs gf slrsyais-wvrqapgngleyigtigssggsayya P201 .1 ....qsleesrgglimpggtltlt c tas gf tistydms-wvrqapgkelewigyisyggspyyts P203 .1 ....qsveesrgglikptdtltlt c tvs gf slssyais-wvrqapgnglewigtigssgstyyas P204 .1 ....qsleesrgglikptdtltlt c tas gf tissydmi-wvrqapgngleyigtiggsgteyyas P207 .1 ....qsveesrgglikptdtltlt c tls gf slssygvi-wvrqapgsgleyigyisyggsafyas P208 .1 ....qsvkeseggllkptdtltlt c tvs gf slrsygvi-wvrqapgnglewigiidsygsayyas P209 .1 ....qsveesrgglikptdtltht c tvs gf slssygvi-wvrqapgngleyigtinsygstyyas P211 .1 ....qsveesrgglikptdtltlt c tvs gf slstyais-wvrqapgkelewigyidndgtyyasc P213 .1 ....qsveeskgglikptdtltlt c tvs gf slssydmi-wvrqapgngleyigiiyasgsaayas P214 .1 qqleqsgggaggglvkpggslelc c kas gf slcssywicwvrqapgkglewigciyagss P216 .1 ....qsveesrgglikptdtltht c tvs gf slssygvi-wvrqapgngleyigtigssgsayyas P218 .1 ....qsvgesrgglikptdtltlt c tas gf sissyrmg-wvrqapgnglewigiisdggsayyas P219 .1 qqleqsgggaggglvkpggslelc c kas gf slsssywicwvrqapgkglewigciyagsr P221 .1 ....qsvkesrgglikptdtltlt c tvs gf slssyais-wvrqapgsglewigiidsygstgyas P222 .1 ...qeqlkesggglvtpggtlslt c tvs gf slssnywicwvrqapgkglewigyidpifgsty P225 .1 ....qsveesrgglikptdtltlt c tvs gf slssygvi-wvrqapengleyigaignsgsayyas P226 .1 ....qsveesrgglikptdtltlt c tvs gf slssygvi-wvrqapgngleyigtistggsayyas P230 .1 ....qelvesggglvqpgeslkls c kas gi dfssygis-wvrqapgkglewigdidpgfgitnya P231 .1 ....qsveesrgglikptdtltlt c ivs gf slssyais-wvrqapgngleyigtigssgnayyas P232 .1 ....qsleesrgglikpggtltlt c tas rf tissytis-wvrqapgnglewigiinsygstyyas P235 .1 ....qsveesrgglikpggtltlt c tvs gf slrsndmr-wvrqapgnglkwigtigssgstyyas P237 .1 ....qsvkesegglikptdtltlt c tvs gf slssyais-wvrqapgnglewigiinsggsayyas P239 .1 ....qsvkesegglfkptdtltlt c tvs gf slssyais-wvrqapgngleyigtitssgsayyas P250 .1 qqleqsgggaggglvkpggslelc c kas gf slsssywicwvrqapgkglewigciyagss ...........-------------FR3----------------------- ----HV3------- ----FR4---> P20 .61 .......waksrstitrntnlntvtlkmtsltaadtatyf c ar drdyg-g--styyd iwgp... P21 .61 .......caksrstitrntnentvtlkmtsltaadtttyf c ar ssd---gy-aavyd iwgp... P29 .61 .......waksrstitrntnlntvtlkmtsltaadtatyf c ar vvn---g----afd pwgp... P30 .61 gstyyaswvngrftlsrdidqstgclqlnsltaadtamyy y ar tgs---gyypsyfn iwgp... P101 61 .......waksrstitrntnentvtlkmtsltaadtatyf c ar ga----gwstg-fn iwgp... P102 61 .......waksrstissntnlntvtlkmtsltaadtatyf c ar wgsvgdgy---tfd iwgp... P103 61 .......waksrstitrntnlntvtlkmtsltaadtatyf c ar vvn---g----afd pwgp... P104 61 .......waksrstitrntnlntvtlkmtsltaadtatyf c ar ---y--gsstg-td iwgs... P105 61 .......waksrstitrntnlntvtlkmtsltaadtatyf c ar nl----gvssg-ld iwgp... P107 61 .......wakgrstitrntnlntvtlkmtsltavdtatyf c ar dnvnsygg--gyvd iwgp... P109 61 .......waksrstitrntnentvtlkmtsltaadtatyf c ar ggagisgy-t-yfn iwgpgtl... P110 61 ....yaswvngrftlsrdidqstgclqlnsltvadtamyy c ar gs-y--gyny-ald iwgp... P111 61 ......nwaksrstitrntnlntvtlkmisltaadtatyf c ar giyyryg--gaygd iwgp... P201 61 .......waksrstitrntnentvtlkmtsltaadtatyf c ag l-----gy---dfn iwgp... P203 61 .......waksrstitrntnlntvtlkvtsltavdtatyf c ar ggsswggysh---- iwgp... P204 61 .......waksqstitrntnlntvtlkmtsltaadtatyf c ar dg----gws-g-vn iwgp... P207 61 .......waksrstitrntnlntvtlkmtsltaadtatyf c ar rrydgsgy---ypd iwgp... P208 61 .......waksrstitrntnentvtlkmtsltaadtatyf c ar syvggsng--gafd pwgp... P209 61 .......waksrstitrntnlntvtlkmtsltaadtatyf c ar rgynsggy--gyad mwgp... P211 61 ........aksrstitrntnentvtlkmtsltaadtatyf c ar ------gyr--yvk iwgp... P213 61 .......waksrstitrntilntvtlkmtsltaadtatyf c as -yp---gysignfn iwgp... P214 61 gstyygswvngrftlsrdidqstgclqlnsltaadtamyy c ar gd--syadayvsfn iwgp... P216 61 .......waksrstitrntnlntvtlkmtsptaadtatyf c ar giy--ysdpcdyad iwgp... P218 61 .......waisrstitrntnlntvtlkmtsltaadtatyf c ar tg-gyysygdayfn iwgp... P219 61 gstyyanwvngrftlsrdidqstgclqldsltaadtamyy c ar ---gd-g-dvtdin iwgp... P221 61 .......waksrstitrntnlntvtlkmtsltaadtasyf c gr ly----gagsnymd iwgp... P222 61 ....yaswvndrftlsrdidqstgclqlnsltvadtamyy c ak gs----gw-gegld iwgp... P225 61 .......waksrstitrntnentvtlkmtsltaadtatyf c ar g-----g--gsa-- iwgp... P226 61 .......waksrstftrntnentvtlkmtsltaadtttyf c vr -d----gyit-g-d iwgp... P230 61 ......nsvkgrftissdkaqntvflqmtsltasdtatyf c vh nd----g-st---n iwgp... P231 61 .......wakcrstitrntnlntvtlkmtsltaadtatyf c ar vt----gyit--fd iwgp... P232 61 .......waksrstisrntnlntvtlkmtsltaadtatyf c ar th------ditgsd iwgp... P235 61 .......waksrstitsntnlntvtlkmtsltaadtatyf c ar ------tyystggd iwgp... P237 61 .......waksrstiirntnlntvtlkmtsltaadtatyf c ar alyagstyy--vfd pwgp... P239 61 .......waksrstitrntnlntvtlkmtsltaadtatyf c ar g---gssyv-yafd iwgp... P250 61 gstyyaswvngrftlsrdidqstgclqltsltaadtatyf c vr -------fwi---- iwgp... Immunoglobulin heavy-chain -Arctic Char- -------export leader-------------FR1---------------HV1------------FR2-------- cACVH1 ..1 .mfpttgvflltvyltgvhgqtltesgpv-vkrpgeshklt c aap gf tf-s-syymg wirqakgkefewi cACVH2 ..1 .mfpttgillptfyltgvhgqtltesgpv-vkkpgesntls c tas gf tf-s-syhma wmkqapgkglefv cACVH5 ..1 .mfpetllllpgscllchcqvvltqaeqsvqgtpggslklt c acs gf tl-s-syrmh wirqapgkglewi cACVH31 .1 .mfpstglllltvyltgvqgqtltesgpv-vktpgeshklt c tas gf tf-s-sywma wirqapgkglewi cACVH130 1 .mfltsllll--aflpylhsisltsspaq-lkppgesvkls c qvs gy al-t-dygtg wirhqagktlewi cACVH3 ..1 mtgklyllllslclpslngqsmesipsgpvpkkpgdtlsls c kgs gf tf-s-sygmh wlrqpagkaldwm cAVCH27 .1 mtgklyllllslclpylngqslesspsssvlkklgetisls c kis gf tf--gshnth wirqpagkslewm cACVH4 ..1 .mrtvwtlvlmvvsvkvfrgqtltesesv-vkkpgdshklt c tys gf gg---nywna wirqasgkglewv cACVH9 ..1 .mrtvwtlvlmvvsvksvtgqtltesesv-vkkpgdshklt c tys gf gg---nywna wmrqasgkglewv cACVH8 ..1 .miicslvlivmsihsvccdirldqsppq-vkrpgdtvkls c tis gf sm--sgfwih wmrqnqgkalewi cACVH124 1 .....................sehnqpnslsvkreetltis c ais gy sltdnsyvva wnrqpakkpmeci cACVH10 .1 ...mfpgslllllaavscvhceeltqpasmtvqpsqlltis c kvs ys vtsvttfwirqpagkt cACVH6 ..1 ...mfsetlmlllaaascvhceeltqpasmtvqpgqsltis c kvs ys vtsywtawirqpagkt ............----HV2---- --------------------FR3------------------- ---HV3-- ------FR4------- cACVH1 ..67 ghih----ggnt yysqsfqgrftisredsssklyiqmnslksedtavyy c gr ---ygngy fdywgkgtmvtvst cACVH130 65 ...giiwaggsi isgdsfksrftisrd-ssnvlylditslqaedtavyy c ar fhaynngy fdywgkgtmvtlst cACVH8 ..67 ..grmn-sn-sp vysdslkgqfaltedvststqfleakslrsedsavyy c ar e-isgngy fdywgkgtng cACVH3 ..69 ..gliyydaskt iyskniegrievtrdnsnsmvylklsglraedsavyy c ar e---dndy fdywgkgtmvtvst cACVH4 ..66 .atisd--ggrt yysqsvqgqftisrdnskqqvylqmnnlntedsavyy c ar e--gngda fdywgkgtmvtvss cACVH5 ..68 iyyh---sdtdk snaqvvqgrftaskd-stn-fylhmsqlkpedsalyy c as -hiag-da fdywgkgtmvtvss cACVH9 ..66 .atisd--ggrt yysqsvqgqftisrdnskqqvylqmnnlntedsavyy c ar e--gngda fdywgkgtmvtvss cACVH31 .67 aysh----stta yysqsfqgrftisrddsssklylqmnslksedtavyy c ar evrgmada fdywgkgtmv cAVCH27 .69 ....gysglglg yhakrfegrmettkansnsmmtlklsglkaedsavyy c ar eggtgmap dywgkgtmvtvst cACVH2 ..67 afiht--ggssp fysqtvqgrftisrddsssklflqmnslksedtalyy c ar ---ygdnr fnywgkgtmvtvss cACVH124 50 ..fyiw-gggsf ylnnalknkfsfrrdmssststltgqnlqtedtavyy c ar cACVH10 .61 lewigyinnagstaykdslknkfsitrdtssntlflkgqslqtedtavyy c ah rlttgasa fdywgkgtmvtvss cACVH6 ..61 .lewigqiytgntiykdslknkfsltldssdkivaltgqnlqtedtavyy c sr dggsay fdywgkgtmvtvst Spotted Ratfish Immunoglobulin heavy-chains (VDJ joined genomic clone) 1 vlhmkqpsvylllpsaeelsthqsvtlt c lvk df tpkeifve w avndqvidasnymntev 61 maasadhnysmysmltisaedwdrghtys c vvghesfplktltravnk c sgkpsfvnislvqmdtvnacq 1 vellqdpsppvviltqtspeditlnkqatav c lis sf rpdklrvd w lkdwqiitsgvvts 61 lsvkedngtfstssrltvpardwrndtvyt c qvthvptqtiivknitkss 1 avptppslyallps c gpstsrgsvtfw c lat ny npepatfs w tsngrsitdqvktypsvl 61 nknglytlssqltiaesqmdnsnir c kvkssswpdvdiplp 1 lhmkqpsvylllpsaeelsthqsvtlt c lvk df tpkeifve w avndqvidasnymntevm 61 aasadhnysmysmltisaedwdrghtys c vvghesfplktltravnk c sgkpsfvnislvqmdtvnacq 1 vdhtkqpsvyillpsaaeltaqqsvtlt c lvk df apkeifvq w tvddkeidvsnykntel 61 madsadrnysmysmltisagewgrgfsys c ivghetfalktltrtvnkssgkpsfvnislvlmdavnacq 1 d c edptgnvkiyflplspkqvlmessvtlt c vvd na pldvnvs w tqgekqls gy gkpsvt 61 erhevmselnvstedwksgkeff c vashedmptpvrekifqrt 1 vdeiqepsppvviltqpspediaihkpgiav c lis gf rpdeltvk w lkdwepitsgvets 61 psvkedngtfttssrltvlarewrsgsvyt c qvshsptqtyivknitkss 20182 1 advvltqpssltgkpgqalrlt c tts gf dlsnkfmfwvrrvpgkglewllryyrrshsdn 20182 61 lyapgirnrvtvikdysdhi c dltinsltvqdtaiyy c ar gy nvysvytgvlidywgqgtmvtvtdg 20441 1 gavvltqpatltgkpgtavrlt c kts gf dlssysmhwvrqvpgkglewllwyyssssnay 20441 61 apgiqsrvtvikensnnifdliiksptvhdtaiyy c ardpgsdyleywgqgtmltvtd 2659 1 gavvltqpatltgkpgtavrla c kts gf tlssyymswvrqvpgkglewllhyhssgseyy 3436 1 avavltqpatltgkpgtavrlt c kts gf tlsstwmswvrqvpgkglewllyyyssgseyy 3435 1 gavvltqpatltgkpgtavrlt r rts gf tlssygmswvrqvpgkglewllyyytsstnay 3434 1 gavvltqpatltgkpgtavrlt c rts gf tlssygmswvrqvpgkglewllyyytsssnay 3433 1 gavvltqpatltgksgtavrlt c kts gf tlsstwmswvrqvpgkglecllyyyssgseyy 3432 1 gavvltqpatltgkpgtavrlt c rts gf nlgnypmhwvrqvpgkglewllhyytsssngy 3431 1 gavvltqpatltgkpgtavrlt c kts gf tlsstwmswvrqvpgkglewllyyyssgseyy 2659 61 apgiqsrvtvikensnnifdliiksptvhdtaiyy c ar liyldy wgqgtmltvtd 3436 61 apgiesrvtvrkdtsnnifdltinsptvhdtaiyy c ar gphtvdfgyldy wgqgtmltvtd 3435 61 apgiqsrvtvirensnnildltinsptvhdtaiyy c vr dhsrgnpnyldy wgqgtmltvtd 3434 61 apsiqsrvtvirensnnifdltinsptvhdtaiyy c ar esgyrelridy wgqgtmltvtd 3433 61 apgiesrvtvrkdtsnnifdltinsptvhdtaiyy c ar ytvgtryldy wgqrtmltvnd 3432 61 apgiesrvtvikedsnnifdliiksptvhdtaiyy c ar adrggqyldy wgqgtmltvtd 3431 61 apgiesrvtvrkdtsnnifdltinsptvhdtaiyy c ar drdtvgsrrgsdy wgqgtmltvnd 1 mrslislslllalfslislslllalfsrvq 31 advvltqpssltgkpgqalrit c rts gf dlskygmnwvwqvpgkwlewllyisytsasnsrytpd 96 iqsrvtvnsnnsnniidlniksptghntaisy c asdx 1 aaavltqpesltgkagqslrlt c ras gl nigrytmfwyrqlpgkqrdqllwhdsssskrf 61 aagienrvtviredsnnifdliikslrvedtatys c ararqwiridnpyywgrgtkvtvt 121 edivkpkpsppgvillppspedmamlrpatav c lif sf epdklsvk w fkdwqpvtsgvvt 181 spsvkedngtysissrltvparewrnggvyi c qvshsptdttivqsitmpt 1 apsrshsdnlyapgirnrvtvikdysdhi c dltinsltvqdtaiyy c ar gy nvysvytgv 61 lidywgqgtmvtvtdavptppslyallps c gpstsrgsvtfw c lat ny npepatfswtsn 121 grsitdqvktypsvlnknglytlssqltiaesqmdnsnir c kvkssswpdvdiplpvell 181 qdpsppvviltqtspeditlnkqatav c lis sf rpdklrvdwlkdwqiitsgvvtslsvk 241 edngtfstssrltvpardwrndavyt c qvthvptqtiivknitksse c vdhgdvkvsflppsqkqvlmessvilt c ivtn 321 spldvnvdwtqgqttlqsghgkqsatepqeviselnisthdwisgkefn c ivshedmptp 381 irekivkrevlhmkqpsvylllpsaeelsthqsvtlt c lvk df tpkeifvewavndqvi 440 dasnymntevmaasadhnysmysmltisaedwdrghtys c v 481 vghesfplktltravnk c sdfptemmle gf ppdesgnlwptastfiilffl 1 ahwrshsdnlyapgirnrvtvikdysdhi c dltinsltvqdtaiyy c ar gy nvysvytgv 61 lidywgqgtmvtvtdavptppslyallps c gpstsrgsvtfw c lat ny npepatfswtsn 121 grsitdqvktypsvlnknglytlssqltiaesqmdnsnir c kvkssswpdvdtplpvell 181 qapsppvviltqtspeditlnkqatav c lis sf rpdklrvdwlkdwqivtsgvvtslsvk 241 edngtfstssrltvpardwrndavyt c qvthvptqtiivknitksse c vdhgdvkvsflppsqkqvlmessvilt c ivtn 321 spldvnvdwtqgqttlqsghgkqsatepqeviselnisthdwisgkefn c iashedmptp 381 irekivkrevlhmkqpsvylllpsaeelsthqsvtlt c lvk df tpkeifvewavndqvid 441 asnymntevmaasadhnysmysmltisaedwdrghtys c v 481 vghesfplktltravnk c sgkpsfvnislvqmdts 1 mssliplslllalfs c vqgavvltqpatltgkpgtavrlt c rts gf nlgsyrmhwvrqvp 61 gkglewllhyytsssngyapgiesrvtvikedsnnifdliiksptvhdtaiyy c areilt 121 tgwdldywgqgtmltvtdatptapslyallpt c gspplegqltfg c laa df spepatfsw 181 tskghpiankgqvksyppvlskagfytassqltieasqvdifnlc c qvkssiwldgdi c f 241 pvvqpsppvvlltqtspedialinqatll c svs gf rpdklivdwlkdgkavtsgietsps 301 lkdngnfstdsrltipakdwrwdvvyscrvthdpsqtliiknitnwnpe c lgevkvsflppspkqvllgdtvtlt c vvte 381 apsgvnvtwtqghmarqsaresrsaqrvtselnvstrewnggkefe c vanhvdmltpkrg 441 tiskkpdqdtnrpsvylllpspeelsahqwvtlt c lvk ef apkeifvewavndqaidasq 501 ytnteamaantshnysmysmlsvsagdwdkgntys c vvgh 541 rsfnssktltryvnktsgkptfvnvslvlvdtvkt c q Mouse immunoglobulin heavy-chain 1 mkmwlnwvflltllhgiq c evkvvesggglvqpggslrls c ats gf tfsdfymewvrqtpgkrlewiaas 71 rskahdyrteysasvkgrfivsrdtsqsvlylqmnalraedtatyy c t r dadygnsyf gy fdvwgagttvtvss Opossum immunoglobulin heavy-chain MVH340 1 mdfrlnwffflitlqgvdsevqlvetggdvrqpggslrlt c tts gf tfsnfymhwirqap MVH287 1 mdfrlnwffflitlqgvdsevqlvetggdvrqpggslrlt c tss gf tfsnyymhwirqap MVH263 1 mdfrlnwffflitlqgvdsevqlvetggdvrqpggslrlt c tts gf tfsnyymhwirqap MVH219 1 .dfrlnwffflitlqgvdsevqlvetggdvrqpggslrlt c tts gf tfsnyymhwirqapg MVH357 1 mdfrlnwffflitlqgvdsevqlvetggdvrqpggslrlt c tts gf tfsnyymhwirqap MVH356 1 mgfglkgifilmilqgvhcdvqlvesggdvrqpggslkls c kas gf tfssydmswvrqap MVH349 1 ..fglngifilmilqgvhcdiqlvesggdvrqpggslkls c kas gf tfssydmswvrqapgk MVH347 1 mgfgligifilsilqgvhcdiqllesggdvrqpggslkls c kas gf tfssygmnwvrqap MVH341 1 mgfglkgifilmilqgvhcdiplvesggdvrqpggslkls c kas gf tfssyymywirqap MVH338 1 mgfglngifilmilqgvhcdiqlvesggdvrqpggslkls c kas gf tfssyemswvrqap MVH237 1 ..fglkgifilmilqgvhcdiqlvesggdvrqpggslkls c kas gf tfssygmywirqapgk MVH281 1 .gfglngifilmivqgvhcdiqlvesggdvrhpggslkls c tvs gf tfsnydmnwvrqtpg MVH202 1 mefglngifilmilqgvhcdiqlvesggdvrqpggslkls c kvs gf tfsnywmswirqap MVH253 1 mgfvlngifipmilqgvhcdiqlvesggdvrqpggslkls c kas gf tfssyymhwirqap MVH261 1 mgfglkgifilmilqgvhcdiplvesggdvrqpggslkls c kas gf tfssyymywirqap MVH300 1 mgfglkgifilmilqgvhcdiplvesggdlrqpggslkls c kas gf tftsygmnwirqap MVH307 1 .....ngifilmilqgvhcdiqlvesggdvrqpggslkls c kas gf tfsnyymswvrqapgkgle MVH306 1 mefglngifilmilqgvhcdvqlvesggdvrqpggslkls c kas gf tfssyymswvrqap MVH298 1 mgfglngifilmilqgvhcdiqlvesggdvrqpggslkls c kas gf tfssyymswvrqap MVH316 1 mgfglkgifilmilqgvhcdiqlvesggdvrqpggslkls c kas gf tfssyymswvrqap MVH299 1 ...................diqlvesggdvrqpggslkls c kas gf tfssyymhwirqap MVH221 1 mrfglngifilmilqgvhcdiqlvesggdvrqpggslkls c kas gf tftnywmswirqap MVH252 1 mgfglkgifilmilqgvhcdiqlvesggdvrqpggslkls c kas gf tfssyemnwvrqap MVH257 1 mefglngifilmilqgvhcdiqlvesggdvrqpggslkls c kas gf tfstyymswvrqap MVH340 61 gkglewvavirnptngltaeyaeavkgrftisrddaskmvylqmnslktedtaiyy c a MVH287 61 gkglewvavirnpgkgltaeygeavkgrftisrddasemvylqmnslkiedtalyy c g MVH263 61 gkglewvavirnpangltaeyaeavkgrftisrddaskmvylqmnslktedtaiyy c a MVH219 61 .kglervavirnpangltaeyaeavkgrftisrddaskmvylqmnslktedtaiyy c a MVH357 61 gkglewvavirnpangltaeyaeavkgrftisrddaskmvylqmnslktedtaiyy c a MVH356 61 gkglewvsaisn..dgsstgyadsvkgrftisrdngnsllhlqmnslkaedtatyy c a MVH349 61 glewvsyisss....gsstnyadsvkgrftisrdngnsllhlqmnslkaedtatyy c a MVH347 61 gkglewvsyin..tdgsstnyadsvkgrfttsrdngnsllhlqmnslkaedtatyy c a MVH341 61 gkglewvsais..sdgsstgyadsvkgrftisrdngnsllhlqmnslkaedtatyy c a MVH338 61 gkglewvslid...tgsstyyadsvkgrftisrdngnsllhlqmnslkaedtatyy c v MVH237 61 glewvsaisy....dgsgtyyadsvkgrftisrdngnsllhlqmnslkaedtatyy c a MVH281 61 kglewvstig....tgsttyyadsvkgrftisrdngnsllhlqmnslkdedtatyy c a MVH202 61 gkglewlsni..ngpgsstnyadsvkgrftisrdngnsllhlqmnslkaedtamyy c a MVH253 61 gkglewlsri..dtagsstryadsvkgrftisrdngnsllhlqmnslkaedtatyy c a MVH261 61 gkglewvsais..sdgsstgyadsvkgrftisrdngnsllhlqmnslkaedtatyy c a MVH300 61 gkglewvsyin..gagsstsyadsvkgrftisrdngnsllhlqmnslkaedtatyy c a MVH307 61 .....wvsgi...dtgsgtyyadsvkgrftisrdngnsllhlqmnslkaedtamyy c a MVH306 61 gkglewisei..sndgsstyyadsvkgrftisrdngnsllhlqmnslkaedtatyy c a MVH290 61 gkglewvsgi...dtgsgtyyadsvkgrftisrdngnsllhlqmnslkaedtamyy c a MVH316 61 gkglewvsri..dtagsstsyadsvkgrftisrdngnsllhlqmnslkaedtatyy c a MVH299 42 gkglewlsri..dtagsstryadsvkgrftisrnngnsllhlqmnslkaedtatyy c a MVH221 61 gkglewlsni..ngpgsstnyadsvkgrftisrdngnsllqlqmnslkaedtamyy c a MVH252 61 gkglewvsyis..sggsstyyadsvkgrftisrdngnsllhlqmnslkaedtamyy c a MVH257 61 gkglewiseis..ndgsdtyyadsvkgrftisrdngnsllhlqmnslkaedtatyy c a Sheep Immunoglobulin mu heavy chain variable region VRB-7 1 MNPLWTLLFVLSAPRGVLSQVRLQESGPSLVKPSQTLSLT C TVS GF SLTVNAVG W VRQAPGKVPEWLGSISTDGS VRB-11 1 MNPLWTLLFVLSAPRGVLSQVRLQESGPSLVKSSQTLSLT C TVS GF SLTSNAVG W VRQAPGKAPEWVAGIHNSGS VRB-7 76 tsynpalksrlsitrdtsksqvslslssvttedtavyy c arrtfsgggfavgdnidywgpgllvtvss VRB-11 76 igynpalksrlsitrdtsksqvslslssvtaedtpmyy c ardysgcgrsavacidywgpgllvtvss Human heavy-chain variable T1-2 ....1 .................gvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyyws .....wirqpagkglewigri T1-5 ....1 ..mkhlwfflllvaaprwvlsqvqlqesgpglvkpsqtlslt c tvs gg sissgsyyws .....wirqpagkglewig HuVH4-3 .1 ..........mwvslftgvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyyws .....wirqppgkglewig HuVH4-2 .1 .. khlwfflllvaaprwvlsqlqlqesgpglvkpsgtlsli c svs gg svsssslywg .....wsrqppgkglewigt HuVH4-1 11 ....hlwfflllvaaprwvlsqvqlqesgpglvkpsqtlslt c svs ga fls-gayyws .....wirqhpgkglew HuVH4-4 .1 mkhlwfflllvaapxmgpvpgaaagvgprpgeafgdpvphlh c lww lh qflllelapavp HuVH4-5 .1 ..mkhlwfflllvaaprwvlsqlqlkesgprlvkasetlslt c tas gg sissssxyywg ....wvrqppgkglewigsvyy HUVH4-6 .1 ................rwvlsqvqlhesgpglvkpsqtlslt c tvs gg sirsggyyws .....warqhpgkglewigyfyy HuVH4-7 .6 ....nlwffllpggxsqmvlsqvqlqqwgagllkssetlslt c avy se sfsvry .........wirqppgkglewige HuVH4-8..3 ldmkhlwfflllvaaprwvlsrvplqesgpglvkpsqtlslt c tvs gd sftsgdsfssggyfwswlrqlpgkglewig HuVH6-9 .1 .....................qvqlqqsgpglvkpsqtlslt c ais gd svssnsaawn .....wirqspsrglewlgrtyy T1-2 ...56 ....ytsgstnynpslksrvtmsvdtsknqfslklssvtaadtavyy c ar dtvrggeceprk T1-5 ...71 ..riytsgstnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar dtvrg HuVH4-3 61 ..riytsgstnynpslksrvtmsvdtsknqfslklssvtaadtavyy c ar dtvrggecepr HuVH4-2 71 ..iyysgstyytnpslknrvtisidtsknqfslklssvtaadtavyy c ar hadyggsl-gy-fdlwgrgalvtv HuVH4-1 76 iaytyyggityynpslknrltvsldtsnhqfflrlgsvtaadtavyy c aa tlgelspldywgqgilvtvssappr HuVH4-4 61 .....regtgvdwicllqglqlqslpqessqhirrhdqepvlpeael c dr cghgrlllfers HuVH4-5 76 ......ggsayynpslksrvtisvdtsknqfslrlnsvtaadtavfy c ar hgsfastwslyfdswgqgtpv HUVH4-6 61 ......sgtkynpslksrvsisvdtsknqfslnltsvtaadagpfyy c aa ggkyalexllgpgtls HuVH4-7 71 ...inhrgstiynpslksrvtisldtpkrqfsltlssvtaadtaiyy c ar aptsgspsnhyyhgmdvwgqgtt HuVH4-8 71 ..hidysggtdynpslksrltmtidtsknlfslklasltaadtavyy c ar sphwrgyyakvhdafdiwgqgrmvt HuVH6-9 56 ..rskwyndyavsvrsritinpdtsknknqfslqldsvtpedtavyy c ar x Human heavy-chain variable region VJ region synovial fluid-arthritis patient ---------FR1-------------HV1-----------------FR2--------------- HV3? CPRF2-B3 .1 vsgspgqsitvs c tgtssdvg synl vswyqqhpgkapklmiydvskrpsgvsnrfsgsks CPRF2-B6 .1 vsgspgqsitis c tgtssdvg gyny vswyqqhpgkapklmiydvsnrpsgvsnrfsgsks CPRF2-T1 .1 vsgspgqsitis c tgtssdvg gyny vswyqqhpgkapklmiydvsnrpsgvsnrfsgsks CPRF2-T2 .1 vsgspgqsitis c tgtssdvg gyny vswyqqhpgkapklmiydvsnrpsgvsnrfsgsks CPRF2-T3 .1 vsgspgqsitis c tgtssdvg nynl vswcqqhpgkapklinyevtkrplgvsnrfsgsks CSNEG2-4 .1 vsgspgqsitis c tgtssdig synl vswcqqhpgkapklmiyevtkrpsgisnrfsgsks DP2-4 ....1 vsgspgqsitis c tgtssdvg synl vswyqqhpgkapklmiyegtkrpsgvsnrfsgsks DS2-T4 ...1 rvwvswtvdhhp a lepavmlg litl slgtnstqgkapkvmiyegskrpsgvsnrfsgsks DS2-B1 ...1 vsaspgqsitis c tgtssdig nsnf vswyqqfpgkapqlmiyevnerpsgvsgrfsgskt BSMN2-2 ..1 vsgspgqsitis c tgtssdvg nydl vswhqqhpgkapqvliyeaskrpsgvsdrfsgsks BSSNEG2-3 1 vsgspgqsitis c tgtssdvg gsky vswyqhhpgeapkliiydvsnrpsgvssrfsgsks BSSNEG2-4 1 vsgspgqsitis c sgttsdig psdy vawyqqhpgrapklliydvsrrpsgvsnrfsasks BSMRF-3 ..1 vsgspgqsitis c tgtssdig gydy vswyqqhpgkapklmiydvsnrpsgvsnrfsgsks BSMRF-2 ..1 vsgspgqsitis c sgtssdig grdy vswyqqhpgkvpkviiydvtnrpsgvcnrfsgsks DP2-5 ....1 vsgspgqsitis c tgtssdvg gyny vswfqqhpgkapklmiydvtnrpsgvsnrfsgsrc DS2-T5 ...1 vsgspgqsitis c tgtssdig gfsy vswyqqhpgkapkliiddvnnrpsgvsnrfsgsks DS2-B2 ...1 vsgspgqsitis c tgtssdvg gyny vswyqqhpgkapkpmifdvtnwpsgvsnrfsgsky ---------FR3-------------- --HV3-- ----FR4---- CPRF2-B3 .61 gntasltisghqaedeadyy c csy adnnsr--vfgggtkltvl CPRF2-B6 .61 gntasltifglqaedeadyy c ssy ttsstv--vfgggtkltvl CPRF2-T1 .61 gntasltifglqaedeadyy c ssy tssstlv-vfgggtkltvl CPRF2-T2 .61 dntasltifglqaedeadyy c ssy tssstlv-vfgggtkltvl CPRF2-T3 .61 gntasltisglqaedeaeyy c ssy agsftyv-vfgggtkvtvl CSNEG2-4 .61 gntasltisglqtedeadyy c csy sgsrtl--vfgggtkltvl DP2-4 ....61 gntapltisglqaedeadcy c csy agsytl--vfsggtkltvl DS2-T4 ...61 gntaslrisglqaedeadyy c csy aggstpr-vfgtgtkvtvl DS2-B1 ...61 gntasltisglqtedeadyf c csy asasiy--vfgtgtkvtvl BSMN2-2 ..61 gntasltisglqpddesdyy c csy agnniw--ifgggtkltvl BSSNEG2-3 61 dntasltifglqaedeadyf c ssy sssgsy--vygtatkvtvl BSSNEG2-4 61 gntasltisglqtedeahyf c ssh tatstv--lfgggtkltvl BSMRF-3 ..61 antasltisglqaedeadyy c isy tisstc- vfgtgtkvtvl BSMRF-2 ..61 gntasltifglqaedeasyy c ssy atsssv--vfgggtkltvl DP2-5 ....61 gntasltifglqaedeadyy c ssy tssdtl--vfgggtkltvl DS2-T5 ...61 gntasltisglqaedeadyy c sty ssrstllyvfgtgatvtvl DS2-B2 ...61 gstasltisglqaedeadyy c tsy tsntt---lfgggtklcsr anti-CD19 mouse single-chain Fv (heavy-chain variable region)FMC63 mouse hybridoma .1 evklqesgpglvapsqslsvt c tvsgvslp dy gvswirqpprkglewlgviwgsettyynsalksrltiikdnsk 76 ..sqvflkmnslqtddtaiyy c akhyyyggsyamdywgqgtsvtvss 121 Bovine heavy-chain variable BL7G1 1 qvqlresgpilvkpsqtlslt c tis gf slssyavdwvrqapgkalewlgginntgrtgyn BL5H4 1 qvqlresgpslvkpsqtlslt c svs gf slssyasgwvrqapgkalewvaaidpgggtyyn BL7B7 1 qvqlresgpslvkpsqtlslt c tvs gf slssyavlwvrqapgktleyvggvdadggaryn BL4H9 1 qvqlresgpslvkpsqtlslt c tis gf slssysvywvrqtpgkaleclggisgsgtagyh BL2C7 1 qvqlresgpslvkpsqtlslt r tis gf slsnyavgwvrqapgkalempgdissggstnyn BL7G1 61 aalksrlsiakdnsrsqvslsvssvttedtatyy c akctfggdrggcgyadayda-wgqgllvtvss BL5H4 61 palksrlsitkdnsksqvslsvrsvtpedtatyy c ttdysgscykltwsvgv----wgqgllvtvss BL7B7 61 ptlksrlsitkdnsksqvslsvssvttedtatyy c aknslfngdgdacgrlev---wgqgllvtvss BL4H9 61 palksrlsvskdnsksqvslsvssvttedtatyy c akstsgaayssscsagnfasyldawgqgllvtvss BL2C7 61 palksrlsitkdnsksqvslsmssvttedtatyy c akytytssgflcdgynhyrdawgqgllvtvss Human Ig heavy-chain variable (from elderly repertoir) ---export leader---><-------FR1-----------------> <--HV1---> <---FR2----> <-----HV2---- ER21U 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglew mgwinpnsggtnya 48sc100 1 .vqlvesggglvqpggslrls c aas gf tfs--syams wvrqapgkglew vsaisgsggstyya 48sc-97 1 .vqlvqsgaevkkpgasvkvs c kas gy tft--sygis wvrqapgqglew mgwisayngntnya 48sc-95 1 .vqlvesggglvkpgrslrls c tas gf tvg--dyams wfrqapgkglew vgfirskayggtte 48sc-93 1 .vqlvesggglvqpggslrls c aas gf tfs--syams wvrqapgkglew vsaisgsggstyya 48sc-91 1 .vqlvesggglvkpggslrls c aas gf tfs--nawms wvrqapgkglew vgriksktdggttd 48sc-88 1 .vqlvesgggvvqpgrslrls c aas gf tfs--sygmh wvrqapgkglew vavisydgsnkyya 48sc-76 1 .vqlvesggglvqpggslrls c aas gf tfs--syams wvrqapgkglew vsaisgsggstyya 48sc-72 1 .vqlvesggglvqpgrslrls c tas gf tfg--dyams wfrqapgkglew vgfirskayggtte 48sc-71 1 vvqlvesggglvqpgrslrls c tas gf tfg--dyams wfrqapgkglew vgfirskayggtt 48sc-33 1 .vqlvesggglvqpggslrls c aas gf tfs--syams wvrqapgkglew vsaisgsggstyya 48sc-31 1 .vqlvesggglvqpggslrls c aas gf tfs--syams wvrqapgkglew vsaisgsggstyya 48sc-29 1 .vqlvesggglvkpggslrls c aas gf tfs--nawms wvrqapgkglew vgriksktdggttd 48sc-28 1 .vqlvesgggvvqpgrslrls c aas gf tfs--sygmh wvrqapgkglew vaviwydgsnkyya 48sc-27 1 .vqlvesggglvkpggslrls c aas gf tfs--dyyms wirqapgkglew vsyisssgstiyya 48sc-16 1 .vqlvqsgaevkkpgasvkvs c kas gy tft--sygis wvrqapgqglew mgwisayngntnya 48sc-15 1 .vqlqesgpglvkpsetlslt c ivs gg smssssyywg wirqppgkglew igsiyysgstyy 48sc-13 1 .vqlvesgggvvqpgrslrls c aas gf tfs--sygmh wvrqapgkglew vaviwydgsnkyya 48sc-10 1 .vqlvqsgaevkkpgasvrvs c mas gy tft--sydid wvrqatgqglew mgwmnpnngntaya 48sc-4 .1. vqlvesggglvqpggslrls c aas gf tfs--syams wvrqapgkglew vsaisgsggstyya 48sc-3 .1. vqlvesgggvvqpgrslrls c aas gf tfs--sygmh wvrqapgkglew vavisydgsnkyya 48sc-2 .1. vqlvesgggvvqpgrslrls c aas gf tfs--sygmh wvrqapgkglew vavisydgsnkyya

Xu-58 1 mdctwrilflvaaatgthaqvqlvqsgaevkkpgasvkvs c kvs gy tlte--lsmh wvrqapgkglew mggfdpedg Xu-57 1 melglcwvflvailegvqcevqlvesggglvqpggslrls c aas gf tfs--syemn wvrqapgkglew vsyisssgs Xu-56 1 ...................qvqlqqsgpglvkpsqtlslt c ais gd svssnsaawn wirqspsrglew lgrtyyrskwy Xu-55 1 ...................qvqlvqsgaevkkpgssvkvs c kas gg tfs--sygis wvrqapgqglew mgriipilgiany Xu-54 1 mdtlcstlllltipswvlsqitlkesgptlvkptqtltlt c tfs gf sisttavgva wfrqppgkalew laliywn Xu-53 1 mefglswvflvallggvqcqvqvvesgggvvqpgrslrls c aas gf tfs--syamh wvrqapgkglew vafistdgs Xu-52 1 mefglswlflvailkgvqcevqllesgggllqpggslrls c aas gf tfs--sydmn wvrqapgkglqw vsgisgsgg Xu-51 1 mdwiwrilflvgaatgahsqmqlvqsgpevkkpgtsvkvs c kas gf tft--ssamq wvrqargqrlew igwivvgsg Xu-50 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsqtlslt c tvs gg sisssdyyws wirqppgkglew igyiyys Xu-49 1 mefglswvflvallrgvqcqvqlvesgggvvqpgrslrls c aas gf tfs--sygmh wvrqapgkglew vavisydgs Xu-48 1 mefglswlflvailkgvqcevqllesggglvqpggslrls c aas gf tfs--syams wvrqapgkglew vsaisgsgg Xu-47 1 ...............evqcevqlvesgggvvrpggslrls c aas gf tfd--dygms wvrqapgrglew vsginwngg Xu-46 2 svsfliflpvlglpwgvlsqvqlqqsgpglvkpsqtlslt c ais gd svs--snsaa wnwirqspsrgl ewlgrtyyrskwy Xu-45 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqpagkglew igriytsgs Xu-44 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglew mgwinpnsg Xu-42 1 mefglswlflvailkgvqcevqllesggglvqpggslrls c aas gf tfs--nyams wvrqapgkglew gsaisnsga Xu-31 1 mefglswvflvaiikgvqcqvqlvesggglvkpggslrls c aas gf tfs--dyymt wirqapgkglew lsylsssgr Xu-28 1 mdtlcstlllltipswvlsqitlkesgptlvkptqtltlt c tfs gf slstsgvgvg wirqppgkalew laliywd Xu-25 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglew mgwinpnsg * Xu-21 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqppgkglew igyiyysgs Xu-20 1 mdwtwsilflvaaatgahsqvqlvqsggevkkpgasvkvs c kas gy tft--nygis wvrqapgqgpew mgwvsgynd Xu-19 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c svs gg siss-ny-ws wirqpagkglew igriyssgs Xu-18 1 mdwtwrilflvavatsahsqvqlvqsgaevkkpgasvkvs c kas gy tft--sydin wvrqatgqglew mgwmnpnsg Xu-17 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglew mgwinpnsg Xu-16 1 mdrtwrilflvaaatsahsqvqlvqsgaevkkpgasvkvs c kas gy tft--sydin wvrqatgqglew mgwmnpnsg Xu-15 1 mefglswlflvailkgvqcevqllesggglvqpggslrls c aas gf tfs--syams wvrqapgkglew vsaisgsgg Xu-14 1 ...................evqlvesggglvqpggslrls c aas gf tfsr--ywmh wvrqapgkglvw vsrinsdgsstry Xu-13 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqpagkglew igriynsdn Xu-12 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglew mgwinpnsg Xu-11 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglew mgwinpnsg Xu-10 1 ...................qitlkesgptlvkptqtltlt c tfs gf slsttgvgvg wirqppakalew laliywdddkr Xu-9 .2 svsfliflpvlglpwgvlsqvqlqqsgpglvkpsqtlslt c ais gd svssnsaawn wirqspsrglew lgrtyyrskwy Xu-8 .1 melglcwvflvailegvqcevqlvesggglvqtggslrls c aas gf tfs--sysmn wvrqapgkglew lsyinsrsn Xu-7 .1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqppgkglew igyiyysgs Xu-6 .1 ...................evqllesggglvqpggslrls c aas gf tfs--syams wvrqapgkglew vsaisgsggstyy Xu-3 .1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglew igeinhsgs Xu-2 .1 mdctwrilflvaaatgthaqvqlvqsgaevkkpgasvkvs c kvs gy tlte--lsmh wvrqapgkglew mggfdpedg Xu-1 .1 mefglswvflvailkgvqceeqpvesggglvqpggslrls c aas gf tfs--gywmh wvrqapgtglvw vsrinsdgt

23u-52 1 ...................qvtlresgpalvkptqtltlt c tfs gf slstsgmcvs wirqppgkalew laridwdddky 23u-51 1 ...................qvqlvqsgaevkkpgasvkvs c kas gy tft--sygis wvrqapgqglew mgwisayngntny 23u-50 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs dg sits-hy-ws wvrqpagkglew igristtgs 23u-48 1 ...................qvqlqesgpglvkpsqtlslt c tvs gg sissgdyyws wirqppgkglew igyiyysgsty* 23u-47 1 melglswvflvailegvqcevqlvesggglvqpggslrls c sas gf tfs--tywmt wvrqapgkglew vanikphgs 23u-46 1 ...................qvqlvqsgaevkkpgasvkvs c kas gy tfi--sypiy wvrqapgqrlew mgwikagngdtry 23u-45 1 ...................evqlvesggglvqsggslrls s aas gf tfsr--ywms wvrqapgqglew vaninqdgsekly 23u-44 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gy siss-gyywg wirqppgkglew igsiyhsg 23u-43 1 mkhrwfllvlvaaprwvlsqvqlqesgpglvkpsqtlslt c tvc gg sissgdyyws wirqppgkglew igyiyys 23u-42 1 ....................vqllesggglvqpggslrls c aas gf pfs--nyvml wvrqaagkgpew vsaisgsggttyya 23u-41 1 ...................qvqlqesgpglvkasetlslt c ivs gd sign-ny-ws wirqppgkglew igyiyssgntnyn 23u-40 1 ............................glvqpggslrls c sas gf tfs--syamh wvrqapgkgley vsaissnggsty 23u-37 1 ...................evqlvesggglvqpggslrls c aas gf tvss-ny-ms wvrqapgkglew vsviysggstyya 23u-36 1 ...................qvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglew igeinhsgstnyn 23u-35 1 ...................qvqlqesgpglvkpsgtlslt c avs gg sis-ssnwws wvrqppgkglew igeiyhsgstny 23u-34 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsgtlslt c avs gg sis-ssnwws wvrqppgkglew igeiyhsg 23u-32 1 ...................qvqlqqwgagllklsedlslt c avy gg sfs--gyyws wirrppgkglew igeinhsgstnyn 23u-31 1 ...................qvqlqesgpglvkpsetmslt c tvs gg sis--syyws wirqppgkglew igyiyysgstnyn 23u-30 1 ............................glvqpggslrls c aas gf tvs--snyms wvrqapgkglew vsviysggstyy 23u-29 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqppgkglew igyiyysgs 23u-27 1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sft--nyycs wirqspgkglew igeihpsgs 23u-26 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglew mgwinpnsg 23u-25 1 mdwiwrilflvgaatgahsqmqlvqsgpevkkpgtsvkvs c kas gf tft--ssamq wvrqargqrlew igwivvgsg 23u-24 1 ...................qvrlvqsgaevkrpgasvkvs c qas gy ift--nyhls wmrqargqglew mgcispyngntny 23u-23 1 mdwtwrilflvaaatsahsqvqlvqsgaevkkpgasvrvs c mas gy tft--sydid wvrqatgqglew mgwmnpnng 23u-22 1 mdwtwrilflvaaatsahsqvqlvqsgaevkkpgasvkvs c kas gy tft--sydin wvrqatgqglew mgwmnpnsg 23u-20 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kaf gy tft--snamh wvrqapgqrlew mgwinagng * 23u-17 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsdtlslt c tvs gg fis--gyyws wirqpagkgldw igriyysgs 23u-16 2 svsfliflpvlglpwgvlsqvqlqqsgpglvkpsqtlslt c ais gd svssnsaawn wirqspsrglew lgrtyyrskwy 23u-10 1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglew igeinhsgs 23u-9 .1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sln--vyywh wirqppgkglew igeinhsgs 23u-5. 1 ...................qvqlvqsgaevkkpgssvkvs c kas gg tfs--syais wvrqapgqglew mgriipilgiany 23u-4 .1 ...................evqlvesggglvqpggslrls c aas gf tfs--syamn wvrqapgeglew isyisgsrstiyy 23u-3 .1 mgstailalllavlqgvcaevqlvqsgaevkkpgeslkis c kgs gy sft--sywig wvrqmpgkglew mgiiypgds 23u-2 .1 ...................qvqlqlsgpglvkpsqtlslt c ais gd svsnnnsawn wirqspsrglewl grtyytskwf 23u-1 .1 mdwtwsilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--sygis wvrqapgqglewm gwisayng 48u-53 1 mdwtwrilflvaaatsahsqvqlvqsgaevkkpgasvkvs c kas gy tft--sydin wvrqatgqglewm gwmnpnsg 48u-52 1 ...................evqlvesggglvqpggslrls c aas gf tfs--sydmh wvrqatgkglewv saigtagdtyyp 48u-50 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqppgkglewi gyiyysgs 48u-49 1 mdwtwrflfvvaaatgvqsqvqlvqsgaevkkpgssvkvs c kas gg tfs--syais wvrqapgqglewm ggiipifg 48u-48 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqpagkglewi griytsgs 48u-47 1 melglcwvflvailegvqcevqlvesggglvqpggslrls c aas gf tfs--sysmn wvrqapgkglewvsyisssss 48u-46 1 mefglswlflvailkgvqcevqllesggglvqpggslrls c aas gf tfs--syams wvrqapgkglewvsaisgsgg 48u-44 1 mkhlwfflllvaaprwvlsqlqlqesgpglvkpsetlslt c tvs gg sissssyywg wirqppgkglewigsiyys 48u-43 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqpagkglewigriytsgs 48u-42 1 melglrwvflvailegvqcevqlvesggglvkpggslrls c aas gf tfs--sysmn wvrqapgkglewvssisssss 48u-41 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsqtlslt c tvs gg sissggyyws wirqhpgkglewigyiyys 48u-40 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqpagkglewigriytsgs 48u-38 1 ...................qvqlvqsgaevkkpgasvkvs c kas gy tft--sygis wvrqapgqglewmgwisayngntny 48u-37 1 mdwtwrflfvvaaatgvqsqvqlvqsgaevkkpgssvkvs c kas gg tfs--syais wvrqapgqglewmggiipifg 48u-36 1 ...................qvqlvqsgaevkkpgasvkvs c kas gy tft--gyymq wvrqapgqglewmgwinpnsggtny 48u-35 1 mkhlwfflllvaaprwvlsqvqlqqrgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglewigeinhsgs 48u-31 1 ...................qvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglewmgwinpnsggtny 48u-30 1 ...................qvqlvqsgtevkkpgasvkvs c kas gy tfs--ayyih wvrqapgqglewmgwidphsagttf 48u-28 1 mdwtwrflfvvaaatgvqsqvqlvqsgaevkkpgssvkvs c kas gg tfs--syais wvrqapgqglewmggiipifg 48u-27 1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglewigeinhsgs * 48u-26 1 ......................llesggglvqpggslrls c aas gf tfs--syams wvrqapgkglewvsaisgsggstyyad 48u-25 1 mdwtwrilflvaaatsahsqvqlvqsgaevkkpgasvkvs c kas gy tft--sydin wvrqatgqglewmgwmnpnsg 48u-22 1 ...................qvqlvqsgaevkkpgssvkvs c kas gg tfs--syais wvrqapgqglewmggiipifgtany 48u-19 1 ...................evqlvesggglvqpggslrls c ags gf pfs--sywms wvrqapgkglewvanikqdgsekyy 48u-18 1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sfs--dyyws wirqppgkglewigeikhsgs 48u-17 1 ...................qvqlqesgpglvkpsetlslt c tvs gg svssgsyyws wirqppgkglewigyiyysgstn 48u-15 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqppgkglewigyiyysgs 48u-13 1 mefglswlflvailkgvqcevqllesggglvqpggslrls c aas gf tfs--syams wvrqapgkglewvsaitgsgg 48u-12 1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyywt wirqppgeglewigeinqsgi 48u-11 1 melglcwvflvailegvqcevqlvesggglvqpggslrls c aas gf tfs--sysmn wvrqapgkglewvsyisssss 48u-10 1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglewigeinhsgs 48u-9 .1 mefglswvflvallrgvqcqvqlvesgggvvqpgrslrls c aas gf tfs--sygmh wvrqapgkglewvaviwydgs 48u-8 .1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglewmgwinpnsg 48u-7 .1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c ras gy tft--gyylh wvrqapgqglewmgwinpnsg 48u-6 .1 mdwtwrilflvaaatsahsqvqlvqsgaevkkpgasvkvs c kas gy tft--sydin wvrqatgqglewmgwmnpnsg 48u-5 .1 ...................qlqlqesgpglvkpsetlslt c svs gg sissssyywg wvrqppgeglewignihysgsay 48u-3 .1 mdwtwrflfvvaaatgvqsqvqlvqsgaevkkpgssvkvs c kas gg tfs--syais wvrqapgqglewmggiipifg 48u-2 .1 mdwiwrilflvgaatgahsqmqlvqsgpevkkpgtsvkvs c kas gf tft--ssavq wvrqargqrlewigwivvgsg 48u-1 .1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglewigeinhsgs 45u-47 1 mefglswvflvailkgvqcevqlvesgggllqpggslrls c eas gf tfs--nywms wvrqapgkglvwvsrtntdgs 45u-46 1 mefglswvflvallrgvqcevqlvesggglvqpggslrls c aas gf tfs--aysmn wvrqapgkglewisyisttss 45u-45 1 mdwtwrilflvaaatgahsqvqlvqsgselkkpgasvkvs c kas gy tft--syamn wvrqapgqglewmgwintntg 45u-44 1 mkhlwfflllvaaprwvlsrvqlqesgpglvkasetlslt c tvs gd sit--nyyws wirqppgkglewigntyssgn 45u-43 1 melglcwvflvailegvqcemqlvesggglvqpggslrls c aas gf tfs--sysmn wvrqapgkglewisyisssss * 45u-42 1 ...................evqllesggglvqpggslrls c aas gf tfs--syams wvrqapgkglewvsaisgsggstyy 45u-41 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqppgkglewigyiyysgs 45u-40 2 svsfliflpvlglpwgvlsqvqlqqsgpglvkpsqtlslt c ais gd svssnsaawn wirqspsrglewlgrtyyrskwy 45u-39 1 mgstailalllavlqgvcaevqlvqsraevkkpgdslkis c kas ay sft--tywig wvrqmpgkglewmgfiypgds 45u-38 1 melglrwvflvailegvqcevqlvesggglvkpggslrls c aas gf tfs--sysmn wvrqapgkglewvssisssss 45u-37 1 ...................evqlvesggglvkpggslrls c aas gf tfs--sysmn wvrqapgkglewvssisssssyiyy 45u-36 1 mdwtwrflfvvaaatgvqsqvqlvqsgaevkkpgssvkvs c kas gg tfs--syais wvrqapgqglewmggiipifg 45u-35 1 ...................qvqlvqsgaevkkpgasvkvs c kas gy tft--syymh wvrqapgqglewmgiinpsggstsy 45u-34 1 ...................evqlvesggglvqpggslrls c sgs gf tfs--sywms wvrqapgqglewvaiikqdgsethy 45u-33 1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglewigeinhsgs 45u-32 1 ...................evqlvqsgaeakkpgdslkms c kgs gy sfn--tywig wvrqmpgkglewmgfiypgdsdtry 45u-31 1 mdwtwrflfvvaaatgvqsqvqlvqsgaevkkpgssvkvs c kas gg tfs--syais wvrqapgqglewmggiipifg 45u-30 1 ...................qitlkesgptlvkptqtltlt c tfs gf slstsgvgvg wirqppgkalewlaliywdddkr 45u-29 1 mgstailalllavlqgdcaevqlvqsgaevkkpgeslkis c kgs gy sft--khwia wvrqmpgkglewmgitfpgds 45u-28 1 mdilcstlllltvpswvlsqvtlresgpalvkptqtltlt c tfs gf slstsgmcvs wirqppgkalewlalidwd 45u-27 1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglewigeinhsgs 45u-26 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglewmgrinpnsg 45u-25 1 mdwtwsilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--sygis wvrqapgqglewmgwisayng 45u-24 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsqtlslt c tvs gg sis--sggyy wswirqhpgkglewigyiyys 45u-23 1 mkhlwfflllvaaprlvlsqvqlqesgpglvkpsqtlslt c tvs gg sis--sggyy wswirqhpgkglewigyiyys 45u-22 1 mdwtwsilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--sygis wvrqapgqglewmgwisayng 45u-21 1 mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglewigeinhsgs 45u-19 1 mdwtwrvfcllavapgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--syymh wvrqapgqglewmgiinpsgg 45u-18 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c svs sg sls--rhywn wirqppgkglewigyiydsgs * 45u-17 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglewmgrinpnsg 45u-15 1 mdwtwrllflvaaatgahsqvqllqsgaevkkpgasvkvs c kas gy tft--tyamh wvrqapgqslewmgwinagkg 45u-14 1 melglswvflvailegvqcevqlvesggglvqpggslrls c aas gf tfs--rydmh wvrqttgkglewvsgigtegd 45u-13 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--syamh wvrqapgqrlewmgwinagng 45u-12 1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--syamh wvrqapgqrlewmgwinagng 45u-11 1 melglswvflvailegvqcevqlvesggglvqpggslkls c aas gf tfg--sywms wvrqapgkglewvanikqdgs 45u-8 1 msvsfliflpvlglpwgvlsqvqlqqsgpglvkpsqtlslt c ais gd svssnsaawn wirqspsrglewlgrtyy 45u-7 1 .mefglswlflvailkgvqcevqllesggglvqpggslrls c aas gf tfs--syams wvrqapgkglewvsaisgsgg 45u-6 1 ....................qitlkecgptlvkttqtltlt c tfs gf slstngegvg wirqppgkalewlaliywdddrr 45u-5 1 .mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tft--syamh wvrqapgqrlewmgwinagng 45u-4 1 ....................qvtlkesgpvlvkptetltlt c tvs gf slsnarmgvs wirqppgkalewlahifsndeks 45u-3 1 .mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirhppgkglewigyiyysgs 45u-2 1 .mdwiwrilflvgaatgahsqmqvvqsgpevrepgtsvkvs c kas gf tfs--tsavq wvrqargqplewigwivvgrg 45u-1 1 .mdtlcstlllltipswvlsqitlkesgptlvkptqtltlt c tfs gf slstsgvgvg wirqppgkalewlaliywd

21u-51 1 .mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqppgkglewigyiyysgs 21u-50 1 ....................qlqlqesgpglvkpsetlslt c tvs gg sirsssyywg wirqppgkglewigyiyysgstf 21u-49 1 ....................qvqlvqsgaevkkpgssvkvs c kas gg tfs--syais wvrqapgqglewmggiipifgtany 21u-48 1 .mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sis--syyws wirqppgkglewigyiyysgs 21u-47 1 ....................evqlvqsgaevkkpgeslkis c kgs gy sft--sywig wvrqmpgkglewmgiiypgdsdtry 21u-46 1 .mkhpwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gd svssstyyws wirqapgkapewigyvyyn 21u-44 1 ....................qvqlqqsgpglvkpsqtlslt c ais gd svsrinsawn wirqspsrglewlgrtyygskws 21u-43 1 .mefwlswvflvailkgvqcevqlvesgggliqpggslrls c aas gf tvs--snymn wvrqapgkglewvsiiysggs 21u-40 1 .melglrwvflvailegvqcevqlvesggglvkpggslrls c aas gf tfs--sysmn wvrqapgkglewvssisssss 21u-39 1 .mkhlwfflllvaaprwvlsqvqlqesgpglvkpsgtlslt c avs gg sis-ssnwws wvrqppgkglewigeiyhsg 21u-34 1 ....................evqlvesggglvqpggslrls c aas gf tfr--nywmr wvrqapgkglewvaninqdgsdrdy 21u-33 1 .mefwlswvflvailkgvqcevrlvesgggliqpggslrls c avs gf svs--skfmt wvrqapgkglewvsilypggn 21u-32 1 .mdwtwrflfvvaaatgvqsqvqlvqsgaevkkpgssvkvs c kas gg tfs--syais wvrqapgqglewmggiipifg 21u-31 1 ....................qvqlvesgggvvqpgrslrls c aas gf tfs--sygmh wvrqapgkglewvavisydgsnkyy* 21u-30 1 .mdwtwrilflvaaatsahsqvqlvqsgaevkkpvasvkvs c kas gy tft--sydin wvrqatgqglewmgwmnpnsg 21u-29 1 msvsfliflpvlglpwgvlsqvqlqqsgpglvkpsqtlslt c ais gd svssntvtwt wirqspsrglewlgrtfy 21u-28 1 ....................qvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglewigeinhsgstkyn 21u-26 1 .mkhlwfflllvaaprwvlsqvqlqesgpglvkpsqtlslt c tvs gg sissgdyyws wirqppgkglewigyiyys 21u-25 1 .melglcwvflvailegvqcevqlvesggglvqpggslrls c aas gf tfs--sysmn wvrqapgkglewvsyitssss 21u-24 1 .mkhlwlflllvaaprwvlsqlqlqesgpglvspsetlslt c tvs gd sisnnnyywg wirqppgeglewignihyt 21u-23 1 .mkhlwfflllvaaprwvlsqvqlqesgpglvkpsqtlslt c tvs gg sissgsyyws wirqpagkglewigriyts 21u-22 1 .mkhlwfflllvaaprwvlsqvqllesgpglvkpsetlslt c tvs ga sis--syyws wirqspgrglewigsvyssgs 21u-21 1 ....................qvqlvesgggvvqpgrslrls c aas gf tfg--ryamh wvrqasgkglewvavtsydeshryy 21u-20 1 .mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c svs gg sis--tyyws wirqppgkglewigyisysgs 21u-19 1 .mdwtwrflfvvaaatgvqsqvqlvqsgaevkkpgssvkvs c kas gg tfs--syais wvrqapgqglewmggiipifg 21u-18 1 ....................qvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglewigeinhsgstnyn 21u-16 1 ....................qvqlvesgggvvqpgrslrls c aas gf tfs--sygmh wvrqapgkglewvaviwydgsnkyy 21u-13 1 .mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlsft c svs gv sissghycws wirqaagkglewighicss 21u-6 .1 .mkhlwfflllvaaprwvlsqvqlqqwgagllkpsetlslt c avy gg sfs--gyyws wirqppgkglewigeinhsgs 21u-4 .1 .mefglswvflvallrgvqcqvqlvesgggvvqpgrslrls c aas gf tfs--sygmh wvrqapgkglewvaviwydgs 21u-5 .1 ..............................lvqpggslrls c aas gf tfs--sysmn wvrqapgkglewvsyissssstiyy 21u-2 .1 ....................qvqlvqsgaevkkpgasvkvs c kas gy tft--gyymh wvrqapgqglewmgwinpnsggtny ---------------------------------------------HV3---------------------FR4----- ER21U ..81 .......qkfqgwvtmtrdtsistaymelsrlrsddtavyy c ar atgdss--glfdy wgqgtlvtvssg 48sc100 61 .......dsvkgrftisrdnskntlylqmnslraedtavyy c ak swrycs--ggscyhtgvptlqh wgqgtlvtvssg 48sc-97 61 .......qklqgrvtmttdtststaymelrslrsddtavyy c ar drsiaaargdy wgqgtlvtvssg 48sc-95 61 .....yaasvkgrftisrddsksiaylqmnslktedtavyy c tr dlhgq---gryrkfdp wgqgtlvtvssg 48sc-93 61 .......dsvkgrftisrdnskntlylqmnslraedtavyy c ak dsapygs-gsypdy wgqgtlvtvssg 48sc-91 61 .....yaapvkgrftisrddskntlylqmnslktedtavyy c tt gg-gy---gdyd-gy-yyyygmdv wgqgttvtvssg 48sc-88 61 .......dsvkgrftisrdnskntlylqmnslraedtavyy c an dkdkk---gy-yyygmdv wgqgttvtvssg 48sc-76 61 .......dsvkgrftisrdnskntlylqmnslraedtavyy c ak eleqwl--gvfdy wgqgtlvtvssg 48sc-72 61 .....yaasvkgrftisrddsksiaylqmnslktedtavyy c tr dpppdeappndhdy wgqgtlvtvssg 48sc-71 61 ....eyaasvkgrftisrddsksiaylqmnslktedtavyy c tr dsfrwellrrvdhdi wgqgtmvtsssg 48sc-33 61 .......dsvkgrftisrdnskntlylqmnslraedtavyy c ak dhygsgsysshyyyyygmdv wgqgttvtsprg 48sc-31 61 .......dsvkgrftisrdnskntlylqmnslraedtavyy c ak ssgatvyyfdy wgqgtlvtfssg 48sc-29 61 .....yaapvkgrftisrddskntlylqmnslktedtavyy c tt dlrgsnkgvakirwdyyyygmdv wgqgttvtsssg 48sc-28 61 .......dsvkgrftisrdnskntlylqmnslraedtavyy c ar erssswygrgtlyfdy wgqgtlvtfssg 48sc-27 61 .......dsvkgrftisrdnaknslylqmnslraedtavyy c ar gv-gy-csggscqnwfdp wgqgtlvtvssg 48sc-16 61 .......qklqgrvtmttdtststaymelrslrsddtavyy c tr rphnwnyggldy wgqgtlvtvssg 48sc-15 61 ......npslksrvtisvdtsknqfslklrsvtaadtavyy c ar edrihnwfdp wgqgtlvtvssg 48sc-13 61 .......dsvkgrftisrdnskntlylqmnslraedtavyy c ar dtryfdwlfdy wgqgtlvtvssg 48sc-10 61 .......qkfqgrvtmtrstsistaymelsslrsedtavyy c ar kgapagqrgaavy wgqgtlvtvssg 48sc-4 61 ........dsvkgrftisrdnskntlylqmnslraedtavyy c an r-gy-yygsgslpyyyygmdv wgqgttvtvssg 48sc-3 61 ........dsvkgrftisrdnskntlylqmnslraedtavyy c ak dwdsy-gy-dy wgqgtlvtvssg 48sc-2 61 ........dsvkgrftisrdnskntlylqmnslraedtavyy c ak dlgqlwssdy wgqgtlvtvssg Xu-58. 76 ...etiyaqkfqgrvtmtedtstdtaymelsslrsedtavyy c at pvgrcsstscyhpldy wgqgtlvtvssg Xu-57. 76 ...tiyyadsvkgrftisrdnaknslylqmnslraedtavyy c ar dfssswyyegdy wgqgtlvtvssg Xu-56 .61 ....ndyavsvksritinpdtsknqfslqlnsvtpedtavyy c ar dpdcsggscwvgrnafdi wgqgtmvtvssg Xu-55 .61 .......aqkfqgrvtitadkststaymelsslrsedtavyy c ar tyyydssgsh-gy-yygmdv wgqgttvtvssg Xu-54 .76 ..ddrryspslssrltiskdtsrnqvvlamtnmdpvdtatyf c ah snsstapdy wgqgilvtvspg Xu-53 .76 ...nrfyadsvkgrftisrdnskntlylqmnslrvedtalyy c ar dprqhrhcidvicysidh wgqgtqvtvssg Xu-52 .76 ...ntyyadsvkgrftisrdnskntlylqmnslkaedtavyy c ak drpyyydsp-gy wgqgtlvtvssg Xu-51 .76 ...ntnyaqkfqervtitrdmststaymelsslrsedtavyy c aa estslsdtyss-gw-sdy wgqgtlvtvssg Xu-50 .76 ..gstyynpslksrvtisvdtsknqfslklssvtaadtavyy c ar rgysy-gy-hwfdp wgqgtlvtvssg Xu-49 .76... nkyyadsvkgrftisrdnskntlylqmnslraedtavyy c ae dwdsy-gy-dy wgqgtlvtvssg Xu-48 .76... styyadsvkgrftisrdnskntlylqmnslraedtavyy c ak adtamdpgdv wgqgttvtvssg Xu-47 .61... stgyansvkgrftisrdnaknslylqmnslraedtalyy c ar dplsiaadgsgafdi wgqgtmvtvssg Xu-46 .81 ....ndyalsvksritinpdtsknqfslqlnsvtpedtavyy c ar dvegtvnsgshfdy wgqgtlvtvssg Xu-45 .76 ....tnynpslksrvtmsvdtsknqfslklssvtaadtamyy c ar dkihhtyyydssgpq-gy-yyyymdv wgkgttvtvssg Xu-44 .76 ...gtnyaqkfqgrvtmtrdtsistaymelsrlrsddtavyy c as sivvvrytwfdp wgqgtlvtvssg Xu-42 .76 ...ttyyadsvqgrftvsrdnskntlylqmnslraedtavyy c at sl-gy-cgggscyfc wgqgtlvtvssg Xu-31 .76 ...tiyyadsvkgrftisrdnaknslflqtnnlraedtavyy c ar vyssswefdy wgqgtlvtvssg Xu-28 .76 ..ddkryspslksrltitkdtsknqvvltmtnmdpvdtatyy c ah sstyd-ss-gy-ylifdy wgqgtlvtvssg Xu-25 .76 ...gtnyaqkfqgrvtmtrdtsistaymelsrlrsddtavyy c ar vgvydilt-gy-ykvvdy wgqetlvtvssg Xu-21 .76 ....tnynpslksrvtmsvdtsknqfslklssvtaadaavyy c ar ytatyyty wgqgtlvtvssg Xu-20 .76 ...ntnyaqkvqgrvamttdtstntaymelrslrsddtavyy c ar dsgtrvtt-gy-gmdv wgqgttvtvssg Xu-19 .76 ....tnynsslksrvsmsvdtpknqfslkltsvtaadtavyy c ar drs-gw-yghey wgqgisvtvssg Xu-18 .76 ...ntgyaqkfqgrvtmtrntsistaymelsslrsedtavyy c aa gvlaaf wgqgtlvtvssg Xu-17 .76 ...gtnyaqkfqgrvtmtrdtsistaymelsrlrsddtavyy c ar vadygdypgdyyygmdv wgqgttvtvssg Xu-16 .76 ...ntgyaqkfqgrvtmtrntsistaymelsslrsedtavyy c ar ytamvnegvdy wgqgtlvtvssg Xu-15 .76 ...styyadsvkgrftisrdnskntlylqmnslraedtavyy c ak dggvy wgqgtlvtvssg Xu-14 .61 .......adsvkgrftisrdnakntlylqmnslraedtavyy c ar dyydfws-gy-ghgmdv wgqgttv Xu-13 .76 ....tnynpslksrvtmsvdmsknqfslnlnsvtaadtavyy c ar gpktlagtssfdn wgqgtlvtvssg Xu-12 .76 ...gtnyaqkfqgrvtmtrdtsistaymelsrlrsddtavyy c ar tagaayfdy wgqgtlvtvssg Xu-11 .76 ...gtnyaqkfqgrvtmtrdtsistaymelsrlrsddtavyy c ar garfgeaydafdi wgqgtmvtvssg Xu-10 .61 ......yspslksrltltkdtsknqvvlimtnmdpvdtatyy c aq rripsvgsgafyi wgqgtmvtvssg Xu-9 ..81 ....ndyavsvksritinpdtsknqfslqlnsvtpedtavyy c ar rlygmdv wgqgttvtvssg Xu-8 ..76 ...siyyadsvkgrftisrdnarsslylqmtslrvedtavyh c ar eyya-gy-sallf ggqgtlvtvssg Xu-7 ..76 ....tnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar kfdyydssghfdi wgqgtmvtvssg Xu-6 ..61 .......adsvkgrftisrdnskntlylqmnslraedtavyy c ak drdmitfggvivigpmdv wgqgttvtvssg Xu-3 ..76 ....tnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar gprvdssgsraafdi wgqgtmvtvssg Xu-2 ..76 ...etiyaqkfqgrvtmtedtstdtaymelsslrsedtavyy c at dahygdafdi wgqgtmvtvssg Xu-1 ..76 ...tttyadsvkgrftisrdnakntlylqmsslraedtavyy c ar aidrs-gw-yifey wdqgtlvtvssg 23u-52 61 ......ystslktrltiskdtsknqvvlkmtnmdpvdtatyy c ar maaagtaapsdy wgqgtlvtvssg 23u-51 61 .......aqklqgrvtmttdtststaymelrslrsddtavyy c ar vrl-gf-dy wgqgtlvtvssg 23u-50 76 ....tnynpslksrvtmsvdtsknqfslnltsvtaadtavyy c ar evqpyrsidy wgqgtlvtvssg 23u-48 61 ......ynpslksrvtisvdtsknqfslklssvtaadtavyy c as yydss-gy-yygddy wgqgtmvtvssg 23u-47 76 ...eayyvdsvkgrftisrdnaknslflqmsslraedtavyy c ar ansldv wgqgttvtvssg 23u-46 61 .......sqrfqgrvtittdtsastaymelsslrsedtavyy c ar ggggdldy wgqgtlvtvssg 23u-45 61 .......vdsvkgrftisrdnaknslylqmnslraedtavyy c ar i-gy-sssafdy wgqgtlvtvssg 23u-44 76 ...styynpslksrvtisvdtsknhfslklssvtaadtavyy c ar gdyssmdv wgqgtrspsphg 23u-43 76 ..gstyynpslksrvtisvdtsknqfslklssvtaadtavyy c ar erpavaafyygmdv wgqgttvtvssg 23u-42 61 ........esmkgrftmsrdnsrntvylqmdslraedtavyh c vk gi-gy-cggdcylrpyyygldv wgqgprspsphg 23u-41 61 ........pslksrvtmsvdtsrnhfslnlnsvtaadtavyy c ar qregrlgtfdy wgqgtrvtvssg 23u-40 51 ......yadsvkgrftisrdnskntlylqmsslraedtavyy c vk datqlryfdwssstldy wgqgtlvtvssg 23u-37 61 ........dsvkgrftisrdnskntlylqmnslraedtavyy c as rpgdssswyagcdy wgqgtlvtvssg 23u-36 61 ........pslksrvtisvdtsknqfslklssvtaadtavyy c ar gdlprvdtamvppnfdy wgqgtlvtvssg 23u-35 61 .......npslksrvtisvdksknqfslklssvtaadtavyy c ar ggivvaspeleyyyygmdv wgqgttvtvssg 23u-34 76 ...stnynpslksrvtisvdksknqfslklssvtaadtavyy c aw dssglfmpqgafdi wgqgtmvtvssg 23u-32 61 ........pslksrvtisvdtsknqfslrltsltaadtavyy c sg gswyagqthysegny wgqgtlvtvssg 23u-31 61 ........pslksrvtisvdtsknqfslklssvtaadtavyy c ar q-gw-lqrywyfdl wgrgtlvtvssg 23u-30 51 .......adsvkgrftisrdnskntlylqmnslraedtavyy c ar ahgw-gy-csstscsnyygmdv wgqgttvtvssg 23u-29 76 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.......aqkfqgrvtmtrdtsistaymelsslrsgdtavyy c ar disrsavaghadyfdy wgqgtlvtvssg 48u-28 76 ...tanyaqkfqgrvtitadeststaymelsslrsedtavyy c ar wp-gy-gsrdyyygmdv wgqgttvtvssg 48u-27 76 ....tnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar gw-atvttsivafdy wgqgtlvtvssg 48u-26 60 .........svkgrftisrdnskntlylqmnslraedtavyy c ak anlitmivvvphpygmdv wgqgttvtvssg 48u-25 76 ...ntgyaqkfqgrvtmtrntsistaymelsslrsedtavyy c ar gsvrmgsraatfqh wgqgtlvtvssg 48u-22 61 .......aqkfqgrvtitadkststaymelsslrsedtavyy c ar qadcsggscydifpnwfdp wgqgtlvtvssg 48u-19 61 .......vdsvkghftisrdnaknslylqmnslragdtavyy c ar aravfrvgttyfdy wgqgtlvtvssg 48u-18 76 ....tnynpslksrvtisvdtsknqfslkltsvtaadtavyy c ar vtyehdss-gy-yytayyyygmdv wgqgttvtvssg 48u-17 61 ......ynpslksrvtisvdtsknqfslklssvtaadtavyy c ar vsqycsstscyfsglygmdv wgqgttvtvssg 48u-15 76 ....tnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar ksivgattnyyyygmdv wgqgttvtvssg 48u-13 76 ...styyadsvkgrftisrdnskntlylqmnslraedtavyy c ak asirttvvtp-gf-dy wgqgtlvtvssg 48u-12 76 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.76rskwyndyaasvksritinpdtsknqfslqlnsvtpedtavyy c ar dhgssnwfdp wgqgtlvtvssg 45u-7 .76 ...styyadsvkrrftisrdnskntlylqmnslraedtavyy c ak aqrgghtamvpwgdy wgqgtlvtvssg 45u-6 .61 ......yraslksrltitkdssenqvvlimtnmdpvdtatyy c vh rnlay wgqgtlvtvssg 45u-5 .76 ...ntkysqkfqgrvtitrdtsastaymelsslrsedtavyy c ar tlnvnvyap wgqgtlvtvssg 45u-4 .61 ......ystslksrltiskdtsksqvvltmtnmdpvdtatyy c ar igesasdrycsggscf-gw-fdp wgqgtlvtvssg 45u-3 .76 ....tnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar gararsgsyrfwfdy wgqgtlvtvssg 45u-2 .76 ...ntnyaqkfqervtittdiststaylelsslrnddtavyy c aa erysgsccwfdp wgqgtlvtvssg 45u-1 .76 ..ddkryspslksrltitkdtsknqvvltmtnmdpvdtatyy c ah ssnptlsdfdy wgqgtlvtvssg 21u-51 76 ....tnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar gy-rpgvaahspfdy wgqgtlvtvssg 21u-50 61 ......ynpslksrvtisvdtsksqfslrlnsvtaadtavyy c ar rgys-gy-gafdy wgqgtlvtvssg 21u-49 61 .......aqkfqgrvtitadeststaymelsslrsedtavyy c ar gqpsritmivddafdi wgqgtmvtvssg 21u-48 76 ....tnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar vkgwell-gf-dy wgqgtlvtvssg 21u-47 61 .......spsfqgqvtisadksistaylqwsslkasdtamyy c ar tysgssdafdi wgqgtmvtvssg 21u-46 76 ..gltiynpsvnsrltismdtsrnhfslnlnsvtaadtavyy c ar grweqslsfydy wgqgilvtvssg 21u-44 61 ....tnyavsvkgrisinpdtsknqfslqlnsvvpedtavyy c ar ggrgectstncffdy wgqgtlvtvssg 21u-43 76 ....tyyadsvkgrftisrdnskntlylqmnslraedtavyy c ar dsedrklyyyfymdv wgtgttvtvssg 21u-40 76 ...yiyyadsvkgrftisrdnaknslylqmnslraedtavyy c at ligveqlvpfdy wgqgtlvtvssg 21u-39 76 ...stnynpslksrvtisvdksknqfslklssvtaadtavyy c ar gppdygdyryfdy wgqgtlvtvssg 21u-34 61 .......vdsvkgrftvsrdnaenamylqmdslraedtavyy c ar rsgggaggryfdy wgqgtlvtvssg 21u-33 76 ....tyytdsvkgrfsisgdkskntlflqmsslraddtavyf c aa ihiryhgpdy wgqgtlltvssg 21u-32 76 ...tanyaqkfqgrvtitadeststaymelsslrsedtavyy c as hddwllyakpyyyyygmdv wgqgttvtvssg 21u-31 61 .......adsvkgrftisrdnskntlylqmnslraedtavyy c ak dfvhgahgg-gy wgqgtlvtvssg 21u-30 76 ...ntgyaqkfqgrvtmtrntsistaymelsslrsedtavyy c ar gtrcsggscyyvdy wgqgtlvtvssg 21u-29 76rskwyseyalfvqtritinpdtsknqfslqlnsvtpedtavyy c ar stgvraidi wgqgtmvtvssg 21u-28 61 ........pslksrvtisvdtsknqfslklssvtaadtavyy c ar gritmvrgviikgpvdy wgqgtlvtvssg 21u-26 76 ..gstyynpslksrvtisvdtsknqfslklssvtaadtavyy c av gtsscfdy wgqgtlvtvssg 21u-25 76 ...vmyyadsvkgrftisrdnaqnslylqmnslrdedtavyy c ar dggycsntncyfgi wgqgtmvtvssg 21u-24 76 ..gatyynpslksrvtisvdtsknqfslnlrsvtaadtavyy c ar lpcsgnscpywyfdl wgrgtlvtvssg 21u-23 76 ..gstnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar ggivpaapdy wgrepghrllr 21u-22 76 ....tnynpslnsrvtisvdmsknqfslklssvtaadtavyf c ar rrdyfdy wgqgtlvtvssg 21u-21 61 .......adsvkgrfiisrdnskntlylqmnsltpedtamyy c ar eelgqlyfdy wgrepwspspqg 21u-20 76 ....tnynpslksrvtisedtsknqfslrlssvtaadtalyy c ar errdttmglyyfdy wgqgtrvtvssg 21u-19 76 ...tanyaqkfqgrvtitadeststaymelsslrsedtavyy c ar drvsggsgynwfdpgarep wspspqg 21u-18 61 ........pslksrvtisvdtsknqfslklssvtaadtavyy c ar gsgwhnfdy wgqgtlvtvssg 21u-16 61 .......adsvkgrftisrdnskntlylqmnslraedtavyy c ar eggssswfdp wgqgtlvtvssg 21u-13 76 ..gttnyspslksrvtmsidtsknhfslsvssvtaadtavyy c ar mgglrhfdn wgqgtlvtvssg 21u-6 .76 ....tnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar arewlfpggfdp wgqgtlvtvssg 21u-4 .76 ...nkyyadsvkgrftisrdnskntlylqmnslraedtavyy c ar dlggplywyfdl wgrgtlvtvssg 21u-5 .51 .......adsvkgrftisrdnaknslylqmnslrdedtavyy c ar lgd-gy-ydfwsgrdefdy wgqgtlvtvssg 21u-2 .61 .......aqkfqgwvtmtrdtsistaymelsrlrsddtavyy c ar eppgtaagtslttgarep wspspqg Immunoglobulin heavy chain, variable region. mouse. FMC63 mouse hybridoma .1 .............evklqesgpglvapsqslsvt c tvs gv slpdygvswirqpprkglewlgviwgsettyyn 61 salksrltiikdnsksqvflkmnslqtddtaiyy c akhyyyggsyamdywgqgtsvtvss Pig Ig heavy-chain variable ....-------------------------FR1--------------------------HV1-----FR2--> VHF 1 mefrlnwvvlfallqgvqgqeklvesggglvqpggslrls c vgs gf dfssygvg wvrqap VHE 1 mefrlnwvvlfallqgvqgeeklvesggglvqpggslrls c vgs gf tfssyavs wvrqap VHC 1 mefrlnwvvlfallqgvqgeeklvesggglvqpggslrls c vgs gf tfssyeis wvrqap VHB 1 mefrlnwvvlfallqgvqgeeklvesggglvqpggslrls c vgs gf dfsdnafs wvrqap VHA 1 mefrlnwvvlfallqgvqgeeklvesggglvqpggslrls c vgs gf tfsstyin wvrqap <---FR2--------HV2-------------------FR3-------------------------------HV3?------------ VHF 61 gkglesla sigsgsyi gstddadsvkgrftissdnsqntaylqmnslrtedtaryy c ar VHE 61 gkglewla gidsgsys gstyyadsvkgrftisrdnsqntaylqmnslrtedtaryy c ar VHC 61 gkglewla giyssg-- gstyyadsvkgrftisrdnsqntaylqmnslrtedtaryy c ar VHB 61 gkglewva aiassdyd gstyyadsvkgrftisrdnsqntvylqmnslrtedtaryy c ai VHA 61 gkglewla aistsg-- gstyyadsvkgrftisrdnsqntaylqmnslrtedtaryy c ar Human immunoglobulin heavy chain variable regions (H.pylori-induced) 105/9 ...1 ..............gslrls c aas gf tfssygmhwvrqapgkglewvavisydgsnkyyadsvkgrftisrdns 106/104 .1 ..............rslrls c aas gf rftthgmhwvrqapgkglewvavisyngrnkyyadyvngrftisrdds 105/9 ..61 kntlylqmnslraedtavyy c akvqigtmigafdi wgqgtlvt 106/104 61 rdtvflqmnslrpedtamyy c akvrgd-gy-g-dy-gy-ldy wgqgtlvt mouse hybridoma JEL 42 anti-bacterial (anti-PEP-sugar PTS) IgG immunoglobulin heavy chain variable region (HPr-specific scFv) .1 ..............qvqlqqsgpelvrpgvsvkis c kgs gy tfttyamhwvkqshakslewiglistysgytny 61 nqkfkgkatmtvdkssstaymelarltsedsaiyy c arvmgeqyfdvwgagttvtvsl mouse immunoglobulin heavy chain variable region anti-Transcription Factor GCN4) (anti-leucine zipper scFv) .1 ..............evmlvesggglvkpggslkls c aas gf afssydmswvrqtpekrlgwvatistggsytyy 61 pdsvkgrftisrdnakntlylqmsslksedtamyy c trktyyrydawftywgqgtlvtvsaasg mouse hybridoma 3C4 immunoglobulin heavy chain variable region" anti-beet necrotic yellow vein virus antibody .1 ..............qvqlqqsgaelvkpgasvkms c kas gy tftsyniywvkqtpgqglerigaiypgnddtsy 61 nqkfkgkatltadkssstaymqlssltsedsavyy c ardygdpyyvmdvwgqgtsvtvss mouse hybridoma WLA-2C4 immunoglobulin heavy chain variable region" anti-human lung adenocarcinoma antibody .1 ..............evqlqqsvpelanagpsvkis c kas gy tftdyymnwvkqshgkslewiglvnpsnggtny 61 nqnfkgkailtvdkssttahmdvrsltsedsaiyh c arrplrvgpwgqgtpvtvsa mouse hybridoma BDI-1 immunoglobulin heavy chain variable region" anti-human bladder carcinoma antibody .1 ..............qvqlvesgaelvkpgasvkls c tas gf nikdtfihwvkqrpeqglewigridpadgnvky 61 dpkfqgkatitadtssntaylqlssltsedtavyy c arsgstvidyyvmdywgqgtsvtvss mouse hybridoma RH14 immunoglobulin heavy chain variable region DNA-binding hybridoma with patient DH .1 ..............qvqlxesggglvqpggslrls c aas gf ifsnfwmtwvrqapgkglewvaninqggskrsy 61 vdsvkgrftisrdnvknslylqmnslraedtavyy c arlvycdywgqgtlvtvss mouse hybridoma CP5 B5-3 immunoglobulin M heavy chain V region" anti-bromelain-treated red blood cell autoantibodies .1 ....mewelsxififallkdvqgevqlletggglvppggsrxls c egs gx tfsgfwmswvrqtpgktlewigdi 71 nsdgsainyapsikdrftifrdndkstlylqmsnvrsedtatyf c mrysnywyfdvwgagttvtvss mouse monoclonal immunoglobulin IgG2a heavy chain variable anti clover yellow vein virus (ClYVV)" Mab10VH 1 ..............vqlqesgpelvrpgvsvkis c kgs gy tftdypmhwvkqshakslewigvistyygntnyn .......61 rnfkgkatmtvdkssstaymelarltsedsaiyy c arlnldgyygfaywgqgttvtvss mouse hybridomas (immunoglobulin heavy chain variable region) anti-?????-peptide epitope V. pc289h 1 qvklqesgpglvnpsqslslt c tvt gy sitsdyawnwirqfpgnklewm-gy-irnsgstty pc287h 1 qvklqqsgpglvkpsqslslt c tvt gy sitsdyawnwirqfpgnklewm-ay-isysgstsy pc283h 1 qvqlqesgpglvkpsqslslt c tvt gy sitsdyawnwirqfpgnklewm-gy-irnggstty Cys7h .1 qvqlqqsgpglvkpsqslslt c tvt gy sitsdyawnwirqfpgnkldwm-gy-isysgstsy Cys3h .1 qvqlqqsgpglvkpsqslslt c tvt gy sitsdyawnwirqfpgnkldwm-gy-isysgstsy Cys24h 1 qvqlqqsgpglvkpsqslslt c tvt gy sitsdyawnwirqfpgnklewm-gy-isysgrtsy Cys23h 1 qvklqesgpglvkpsqslslt c tvt gy sitsdyawngirqfpgkklewm-gy-irysgstsy Cys16h 1 qvqlqesgpglvkpsqslslt c tvt gy sitsdyawnwirqfpgnklewm-gy-isysgrtry Cys11h 1 qvqlqesgpglvkpsqslslt c tvt gy sitsdyawnwirqfpgnklewm-gy-isysgstry Cys10h 1 qvklqesgpglvkpsqslslt c tvt gy sitsdyawnwirqfpgnklewm-gy-isysgstry pc289h 61 tpslksrisitrdtsknqfflqlnsvttedtatyy c ar ggt-gf-aywgqgtlvtvsa pc287h 61 npslksrisitrdtsknqsflqlnsvttedtaiyy c ar ggt-gf-dywgqgttltvss pc283h 61 npslksrisitrdtsknqfflqlnsvttedtatyy c ar ggt-gf-tywgqgtlvtvsa Cys7h .61 npslksrisitrdtsknqfflqlnsvttedtatyy c ar ggt-gf-dywgqgttltvss Cys3h .61 npslksrisitrdtsknqfflqlnsvttedtatyy c ar ggt-gf-dywgqgttltvss Cys24h 61 npylksriyitrdtsknqfflqlnsvttedtatyy c ar ggt-gf-aywgqgtlvtvsa Cys23h 61 npslksrisitrdtsknqfflqldsvttedtatyy c ar ggt-gf-dywgqgttltvss Cys16h 61 npylksriyitrdtsknqfflqlnsvttedtatyy c ar ggt-gf-aywgqgtlvtvsa Cys11h 61 kpslksrisitrdisknqfflqlnsvttedtatyy c ar ggt-gf-dywgqgttltvss Cys10h 61 kpslksrisitrdisknqfflqlnsvttedtatyy c ar ggt-gf-dywgqgttltvss Goldfish IG HEAVY CHAIN PRECURSOR V REGION HVO5 1 mefwlswvflvailkgvqcevqlvesgggliqpggslrls c aas gf tvssnymswvrqpp HVO3 1 mrlwlhlvllvatlegvrsqvqlvesggdvkkpgdslrls c kas gy tfsgytmywvrqap HVO5 61 gkglewvsviysggs-tyyadsvkgrftisrdnskntlylqmnslraedtavyy c ar HVO3 61 gkglewvsriyddgsdvsyadtvkgrftisrdnaknllylqmsnlkpedtgryy c ar Human IG (Mot) HEAVY CHAIN V-I REGION (unusual papain cleavage sites) .1 ..............qvqlvqsgaevkkpgssarls c kvs gd dfntydihwvrqapgrglewmavvhpsddrtty 61 gprsqarftvtrdsstttvymeltalisadtaiyy c argahysdtddsgtslgpwgqgtllivss Human- Rearranged IG HEAVY CHAIN V-II REGION (SESS) Deletion of CDR2 .1 mdilcstlllltvpsgvlsqvnlresgpalvkathtltlt c tfs gl svntrgmsvswirqppgkalewlaridwd 76 ddkyygtsletrltiskdtsknqvvlkvtnmdpadtatyy c armqvtmvrevmitsnafdiwgqgtwspslq Mouse IG-alpha HEAVY CHAIN V REGION (MOPC 315) Anti-dinitrophenyl activity .1 mkvlsllylltaipgimsdvqlqesgpglvkpsqslslt c svt gy sitsgyfwnwirqfpgnklewlgfikydgs 76 .ngynpslknrvsitrdtsenqfflklnsvttedtatyy c agdndhlyyfdywgqgttltvss HUMAN IgG3 IMMUNOGLOBULIN V REGION VH3 (IGG3/IG HEAVY CHAIN V-III REGIONS) identification of four heavy chain hypervariable regions HV3S .1 ...................dvqlvesggglvkpggslrls c aas gf tfstawmkwvrqapgkglewvvwrveqvvekaf TUR ..1 ...................evqllesggglvqpggslrls c aas gf tfsrvlsswvrqapgkglewvsgrlnassnlhf ZAP ..1 ...................evqlvesggalvqpggsgrls c aas gf tfsttsrfwvrqapgkglewvefrvqgsaishy TEI ..1 ...................evqlvesggglvqpggslrls c aas gf tfstsavywvrqapgkglewvgwryegsslthy WAS ..1 ...................evqllesggglvqpggslrls c aas gf sfstdamywvrqapgkglewvawkyqeasnshf LAY ..1 ...................avqllesggglvqpggslrls c aas gf tfsasamswvrqapgkglewvawkyengndkhy POM ..1 ...................evqllesggglvqpggslrls c aas gf tfsssamswvrqapgkglewvawkyengndkhy TIL ..1 ...................evqllesggglvqpggslrls c aas gf tfstyvmswvrqapgkglzwvgaizglsvszsy VH26 .1 mefglswlflvailkgvqcevqllesggglvqpggslrls c aas gf tfssyamswvrqapgkglewvsaisgsggstyyg Dob ..1 ...................evqlvesggdlvqpgrslrls c aas gf nfheynmhwlrqgpgkgpewvstitwnggsvly Jon ..1 ...................dvqlvesggglvkpggslrls c aas gf tfstawmkwvrqapgkglewvvwrveqvvekaf Cam ..1 ...................qvelvesgggvvzpgrslrls c aas gf tfsnyamhwvrqppgkglewvavisybgbbkyy HV3S 61 ansvngrftisrndskntlylqmisvtpzbtavyy c arvvvstsmdvwgqgtpvt TUR .61 avsaqgrftisrndskntlylqmlslqazbtalyy c arlsvtavafdvwgqgtkvs ZAP .61 adsvqarftisrndskntlylqmntgeazbtavyy c artrpggyfsdvwgqgtlvs TEI .61 avsvqgrftisrndskntlylqmlslepzbtavyy c arvtpaaasltfsavwgqgtlvt WAS .61 adtvngrftisrndskntlylqmnrleazbtavyy c arfrqpfvqffdvfgqgtlvt LAY .61 adsvngrftisrndskntlylqmnglqazvsaiyy c ardagpyvsptffahwgqgtlvt POM .61 adsvngrftisrndskntlyllmnslqazbtalyy c ardagpyvsptffahygqgtlvt TIL .61 absvkgrftisrddsknt----mnslraedtavyy c akgkvsayyfbywgzgtlvtvss VH26 61 -dsvkgrftisrdnskntlylqmnslraedtavyy c ak Dob .61 adsvkgrfaisrdnaqktlylqlnilrpedtafyy c akgyiwngnwfdswgqgtlvtvss Jon .61 ansvngrftisrndskntlylqmisvtpzbtavyy c arvvvstsmdvwgqgtpvt Cam .61 absvkgrftisrdbskbtlylqmnslraebtavyy c ardrplygbyrafnywgqgtlvtvss Mouse IG HEAVY CHAIN V REGIONS (TEPC 15, S107, HPCM1, HPCM2, AND HPCM3). anti-phosphorylcholine-binding proteins HPCM .1 ................evklvesggglvqpggslrls c ats gf tfsdfymewvrqppgkrlewiaasrnkandytt HPCM 61 eysasvkgrfivsrdtsqsilylqmnalraedtaiyy c ardyygssywyfdvwgagttvtvss Mouse IG HEAVY CHAIN PRECURSOR V REGION 93G7 1 mgwsfiflfllsvtagvhsevqlqqsgaelvragssvkms c kas gy tftsyginwvkqrpgqglewigyinpgng 93G7 76 yinynekfkgkttltvdkssstaymqlrsltsedsavyf c arshyyggsydfdywgqgtpltvss Mouse MYELOMA THAT SECRETES IGG2BIG HEAVY CHAIN V REGION" MPC 11 .1 ..............eaqlqqsgaelvrpgtsvkis c kaa gy tftnywigwvkerpghglewigdiypgggftny MPC 11 61 ndnlkgkatltadtssstayiqlssltsedsaiyh c argiyynsspyfdswgqgttltvss Canine myeloma mu chain IG HEAVY CHAIN V REGION MOO .1 .............evklvesggdlvkpggslrls c vas gf tfssngmswvrqdpgeglqwvadisssgqtyya MOO 61 davkgrfsisrdnakntlylqmedlrvedtavyy c ategdieipryfgqgtivtvss Canine MYELOMA PROTEIN IG HEAVY CHAIN V REGION GOM .1 ..............evqlvesggdlvkpggslrls c vas gi tfsgydmqwvrqapgkglqkvayfndalsaqgy GOM 61 adavkgrftiskdnakdslylqmnslraedtavyy c apwqfeywgqgtlvtvss Mouse hybridoma IgG1 (antiscorpian hemocyanin) A102 .1 ..............qvklqqsgtelvkpgasvkls c kas gy tftsywmhwvkqrpgqglewigninpsygdtny A102 61 nekfkskatltvdkssstaymqlssltsedsavyy c arpwvgywgqgttltvs Mouse Ig variable region heavy chain (VH205.12 sub-family) CPS1.2 .1 mgwswifllflsgtagvlsevqlqqsgpelvkpgasvkip c kas gy tftdynmdwvkqsh BPS3.24 1 mewswiflfllsgtagvlsevqlqqfgaelvkpgasvkis c kas gy tftdynmdwvkqsh BPS3.23 1 mgwswiflfllsgtagvlsevqlqqsgpelvkpgasvkis c kts gy tfteytmhwvkqsh C36e ...1 mgwscimlflaatatgvhspvqlqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrp C31e ...1 mgwsyiilflvatatgvhsqvqlqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrp C26c ...1 mgwscimlflaatatgvhsqvqlqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrp B23c ...1 mrwsciilflvatatgvhsqvqlqqpgaelvkpgasvkvs c kas gy tftsywmhwvkqrp BPS3.8 .1 mewswiflfllsgtagvlsevqlqqfgaelvkpgasvkis c kas gy tftdynmdwvkqsh BPS1.1 .1 mgwswiflfflsgtagvlsevllqqsgpelvkpgasvkip c kas gy tftdynmdwvkqsh CPS4.3 .1 mgwnwifililsvttgvhsevqlqqsgpelvkpgasvkis c kas gy sftgyymnwvkqsp CPS2.29 1 mgwswifllflsgtagvlsevqlqqsgpelvkpgasvkip c kas gy tftdynmdwvkqsh CPS12 ..61 gkslewigdinpnnggtiynqkfkgkatltvdkssstaymelr BPS324 .61 gkslewigdinpnydstsynqkfkgkatltvdkssstaymelr BPS323 .61 gkslewigginpnnggtsynqkfkgkatltvdkssstaymelr C36e ...61 grglewigridpnsggtkynekfkskatltvdkpsstaymqls C31e ...61 gqglewigmihpnsgstnynekfkskatltvdkssstaymqls C26c ...61 grglewigridp-ysdikysekfknkatltvdkpsntaymqls B23c ...61 gqglewigrihpsdsdtnynqkfkgkatltvdkssstaymqls BPS3.8 .61 gkslewigdinpnydstsynqkfkgkatltvdkssstaymelr BPS1.1 .61 gkslewigdinpnnggtiynqkfkgkatltvdkssstaymelr CPS4.3 .61 ekslewigeinpstggttynqkfkakatltvdkssstaymqlk CPS2.29 61 gkslewigdinpnnggtiynqkfkgkatltvdkssstaymelr Mouse immunoglobulin heavy chain variable region (VH186.2-related") BHS2.2 .1 mgwsyiilflvatatgvhsqvqlqqsgaelvkpgasvkls c kas gy tftsyymywvkqrp BHS2.23 1 mgwsyiilflvatatgvhsqvqlqqpgaelvkpgasvkls c kas gy tftsyymywvkqrp BHS5.18 1 mgwsyiilflvatatgvhsqvqlqqpgaelvkpgasvkls c kas gy tftsywmywvkqrp BHS2.9 .1 mgwsyiifflvatatgvhsqvqlqqpgaelvkpgasvkls c kas gy tftsywmhwvklrp BHS2.19 1 mgwsciilflvatatgvhsqvqlqqpgaelvkpgasvkms c kas gy tftsynmhwvkqtp CHS1.22 1 mgwsciilflvstatgvhsqvqlqqpgaelvmpgasvkls c kas gy tftsywmhwvkqrp BHS2.2 .61 gqglewigeinpsnggtnfnekfkskatltvdkssstaymqls BHS2.23 61 gqglewigginpsnggtnfnekfkskatltvdkssstaymqls BHS5.18 61 gqglerigeinpsnggtnynekfkskatltvdkssstaymqls BHS2.9 .61 gqgfewigeinpsnggtnynekfkrkatltvdkssstaymqls BHS2.19 61 gqglewigaiypgngdtsynqkfkgkatltadkssstaymqls CHS1.22 61 gqglewigeidpsdsytnynqkfkgkatltvdkssstaymqls Mouse anti-DNA antibody SEC F2/3 immunoglobulin variable heavy chain F2/3 1 ..............qvqlqqpgaelvkpgasvkms c kas gy tftsysmhwvrqrpgqglewigvidpsdsntry ....61 nqkfkgkatltvdtssstaymqlssltsedsavyy c trrsawfaywgqgtlvtvs mouse immunoglobulin heavy chain MMIG22 1 mdfgliffivallkgvqcevkllesggglvqpggslkls c aas gf dfsrywmswvrqapg MMIG22 61 kglewigeinpdsstinytpslkdkfiisrdnakntlylqmskvrsedtalyycar Human immunoglobulin heavy chain variable region anti-hepatitis B virus surface Ag Fab fragment HBS7H .1 ..............qvklleesggglvqpggslrls c ais gf tfsdyavswvrqapgkglewvstisgsagnty HBS7H 61 yadsvkgrliisrdtsrnmlflqmnslraedtavyy c akvkmvrg-gy-wfygmdvwgqgtavrvss Human immunoglobulin heavy chain variable anti-HLA alloantibodies EBV transformed human B-cell line fused to heteromyeloma .1 ggglvkpggslrls c aas gf tfrsysmn wvrqapgkglewvssirsgttyrnyadsvkgr .1 ggglvhpgrslrls c aas gf tfddyamh wvrqapgkglewvsgiswnslnigyadsvkgr .1 gpglvkpsetlslt c svs ga sissnsyywd wvrqppgkglewigniyysgstyynpslrs .1 ggglvkpggslrls c aas gf tfsnawms wvrqapgkglewvgriksktdggttdyaapvk .1 ggglfkpggslrls c aas gf tfrshgmn wvrqapgkglewvssissstsyiyyansvkgr .1 ggglvkpggslrls c aas gf sfshytmn wvrqapgkglewvssisssgryiyhadsmkgr 61 ..ftisrdnarnslylqmnslrgedtavyy c vrghlenydlwsgctfdf wgqgtlvtvss 61 ..ftisrdsaknslylhmnslraedtalyy c akgpialavtefdy wgqgtlvtvss 61 .rvtisvntsnnqfslklrsvtaantavfy c akgpg-gy-tygednyyyhyrldv wgpwtsvtvss 61 grftisrddskntlylqmnslktedtavyy c ttyaryssswyfdy wgqgtlvtvss 61 ..ftisrdnaknslylqlnslrvedtavyy c ardydss-gw-fhafdi wgqgtmvtvssastkgpsvfplapsskstsggtaa 61 ..ftisrdnaknslylqmnslraedtavyy c ardrpg-gy-csgvscystygmdv wgqgttvtvssastkgpsvfplapsskstsggtaa HUMAN IgG heavy chain variable region derived from 'control' healthy individuals" .1. 1 evqllesggglvqtggslrls c aas gf tfs-sy-amswvrqapgkglewvssiggsdgstdy .2. 1 evqllesggglvqpggslrls c aas gl tfs-ih-amrwvrqapgkgpewvsaitgsgvdtyy .3. 1 evqllesggglvqpggslrls c eas gf tfs-gy-tmnwvrqapgkglewvsvitgsssttny .4. 1 evqllesggglvqpggslrls c aas gf tfs-sf-amswvrqapgkglewvsgisvnggstyy .5. 1 ........pglvnpsqtlslt c ais gd svssnsaawywirhspsrglewlgrtyyxstwnydyaesvk .6. 1 ........pglvkpsqtlslt c ais gd svssndavwnwirqspsrglewlgrtyyrstwnidyaetvk .7. 1 ........pglvkpsqtlslt c ais gd svsrngvawnwirqspsrglewlgrtyyrskwyndyavsvk .8. 1 ........pgxvkpsqtlslt c ais gd svssndaawnwirqspsrglewlgrtyyrskwyndyavsve .9. 1 ........pglvkpsqtlslt c ais gd svssnsaawywirqspsrglewlgrtyyrskwyfdyavsvk 10 .1 ........pglvkpsqtlslt c ais gd svsstsaawywirqspsrglewlgrtyyrtkwnydyaesvk 11 .1 ........pglltpsqtlslt c ais gd slftdnvawnwirqspsrglewlgrtyyrskwyndyavsvk 12 .1 ........pglvkpsqtlslt c ais gd svsrnsaawnwirqspsrglewlgrtyyrskwyndyavsve .1 61 adsvkgrftisrdnskdtlylqmnslkaedtavyy c akghgdyrpsnyldvwgkgttvtvslastkg .2 61 adsvkgrftvsrdnskntlylqmnslraedtavyy c aklq-gy-ygsgsylvwtsga .3 61 ahsvkgrftisrdnskntlylqmdslraedtavyy c akdle .4 61 adsvkgrftisrdnskntlflqmnslraedtavyy c aintqi .5 61 ....sxitinpdtsnkpilpatelcdsrxhgcvfl c kehqtggltsgaxetlvxvssslh .6 61 .....srvtinpdttknqfslqlnsvtpedtaiyy c arentlvrgalnaldywgqgtlvtvssast .7 61 .....sritinldtstnqfslqlnsvtpedtavyy c argvnsafdiwgqgtmvtvssastkgpsv .8 61 .....srisinpdtskdqfslqlnsvtpedtavyy c arwdheikifdywgqgtlvtvssastkgpsv .9 61 .....sritinpdtsknqfslqlssvtpedtavyy c ardpagdqgldywgqgtlvtvssastkgpsv 10 61 .....sriainpdtsknqfslqlssvtpedtavyy c ardpagdqgldywgqgnpghrllslhqgpigl 11 61 .....sritinpdtsknqfslqlnsvtpedtavyy c ardtvrgsqceprhkppcrdaqdpegtqhy 12 61 .....sritinpdtsknqfslqlnsvtpedtavyy c argtfqfdswgqgnpghrllglhqgpigl Human blood donor CG sequence from a single CD5(-) B lymphocyte, Ig Hv region BF1N-g1F03 1 ..............vkkpgssvkvs c ras gg tfssyaiswvrqapgqglewmggiipifgtanyaqkfqgrvti ..........61 tadeststaymelsslrsedtavyy c aslydfwsgsqkgtwyyygmdvwg Mexican Axolotl immunoglobulin heavy chain variable regions VH9.38M ..1 ..............mlpqiplnlnvciclfflsgiqgqilltqpiseilkpgqdvslr c tas gy tlsdhhmhwm VH11.5M ..1 ..................mtrvvlfacfllftswviaqitlleagpgtvkpsqdlgls c kvt gy lyssawwa wvrqpp VH10.33Y .1 .................mraffaflivlaiiagvfsqvshcsgpslklwppeasvtmt c tis ss tgywin wvrqapg VH9.103M .1 ..............mlpqiplnlnvciflfflsgiqgqilltqpiseilkpgqdvslr c tas gy tlsdhhihwm VH9.1M ...1 ..............mlpqiplnlnvciflfflsgiqgqilltqpiseilkpgqdvslr c tas gy tlsdhhmhwm VH9.42M ..1 ..............mlpqiplilnfciflfflsgiqgqilltqpiseilkpgqdvslr c tas gy tlsdhhmhwm VH9.85M ..1 ..............mlpqiplnlnvcislfflsgiqgqilltqpiseilkpgqdvslr c tas gy tlsdhhihwm VH8.40M ..1.................. mssvctylcvvlcascvlcqvsllesgpglvkpsetlrlt c kvt ga sltdscccwn wtgk VH8.46M ..1 ..................mspvctylcvvvcascvlcqvtllesgpavvkpsetlrlt c kvt ga sltdscccwn wtgk VH7.15M ..1 ..............msphllssmwllafllhgftgavdilltqvgdavkkpgeshels c rgs gf sfedypmn wv VH6.65Y ..1 ..................mhasilsplllwasfcaaaqvtlresgpgtvkpsgtlsls c evs tp h-gy-ypq wvrvavrg VH5.43M ..1 ..................mslplqisllilglscvhsqivltqsgsevkkpgesmqlk c tvt gf nvnsywmh wvrqap VH4.8Y ...1 ...................mislsligflllvptchsqlslvqtgkwivqpsqsfqld c avs ss sitdsskvwsiq wvr VH4.33M ..1 ..................mislsllgflllvptcvhsqlslvqtgkwivqpsqsleld c avs gg sitdsskvwsiq wv VH3.73M ..1 .................mtgstfklflfaagmscvrsqivltqsgsetrkpgeslqla c avt gf aindyymg wikqv VH3.49M ..1 .................mtgstfklflfaagmscvrsqivltqsgsetrkpgeslqla c avt gf aindymg wikqvp VH2.73Y ..1 ..................mpslyaglvllfahtgvhsqismresgpgvlqplhthrvm c kvt ga sltdssnmhgvh wi VH2.29M ..1 ..................mrslyaallfvfahtgvhsqismllsgpgvlqpsqtlrvv c kvs ga sltdisnvhgvh wi VH1.182M .1 ..................msifitlvvamtfpfgaisqvtllqsgpgqvkpsetltlt c kvs ss ls-gy-ywa wirqppg J1 .......1 ..................mslplqisllilglscvrsqivltqsgsevkkpgesmqlk c tvt gf nvnsywmh wvrqap J2 .......1 ..................mslplqisllilglscvrsqivltqsgsevkkpgesmqlk c tvt gf nvnsywmh wvrqap VH9.38M .61 ....aqtvgeglrwigayrhdttyvadifnprasfslqastfvlrisgmtpagtamyy c ar VH11.5M .61 ....wrgvwnglecskmmttedsllllskvdapsqrtilktstmrmtgmraedtatyy c ar VH10.33Y 61 ....kglewigrihpdekninyapsftgrfvlsrvnaqglvy-lrvtglktedsamyy c ar VH9.103M 61 ....aqtvgeglrwigayrhdttyvadifkgrasfslqastfvlrisgmtpadtamyy c ar VH9.1M ..61 ....aqtvgeglrwigayrhdttyvadifkgrgsfslqastfvlrisgmtpadtamyy c a VH9.42M .61 ....aqtvgeglrwigayrhdttyvadifkgrasfslqastfvlrisgmtpadtamyy c ar VH9.85M .61 ....aqtvgeglrwigayrhdttyvadifkgrasfslqastfvlrisgmtpadtamyy c ar VH8.40M .61 .......glqwlgricsggstnypeslksrvtvtrdtsrneyslqmssaraedtatfy c a VH8.46M .61 .......glqwlgricsggstnypeslksrvtvtrdtsrneyslqmssaraedtatfy c ar VH7.15M .61 qaapgkglewiayivavggtkyytpavqgrftisrdnpsstarlhmgslrtedtakyy c ar VH6.65Y .61 .......glewmgqisdggipyyapshqsrvtitrdiskkvvyfqmtdmgtedssmfy c av VH5.53M .61 .....gkglewvaryysgsnppqytsdavkgrvtastdsssfnlqmnslktedtgvyy c ar VH4.8Y ..61 ..qlagvgiqwvggiwhdgtpryaqsfqsrctvsrdtgknsvhlqlrqmtpddgatyy c ar VH4.33M .61 .rqpagqgiqwvggiwhdgtpryaqsfqsrctvsrdtgknsvhlqlrqmtaddgatyy c ar VH3.73M .61 .....pakglewlvlyhkpsatnyyssavqgrftaskdstnfllqmpalktedsavyy c ar VH3.49M .61 .......qglewlvlyhkpsatnyyssavqgrftaskdstnfylqmpalktedsavyy c ar VH2.73Y .61 .rqtlgkglewvggiyhnndiyrsqslqsrvtisrdtankevylelrsvetrdrgtyy c ar VH2.29M .61 .rqppgrglewvgviyyensiyqsqalksrvtisrdtakmevylelrsvetgdggtyy c ar VH1.182M 61 .....kglewlgiihysgsptyyapslqsrttmtrefptkrvslkmtgmgaddaakyy c ar J1 ......61 .....gkglewvaryysgsntpqytsdavkgrvtastdsssfnlqmnslktedtgvyy c arex J2 ......61 .....gkglewvlrfhsgrnppqyaseavkgrvtastdssscymqmnslktedtgiyy c ardx Mouse hybridoma IgG2a heavy chain variable region B subfamily of the murine I V-region anti-human CD28 antibody 9.3, .1 .............qvqlkesgpglvtpsqslsit c tvs gf slsdygvhwvrqspgqgleclgviwagggtnyn 61 salmsrksiskdnskgqvflkmkslqaddtavyy c ardkgysyyysmdywgqgtsvtvss mouse hybridoma IgG1 heavy chain variable region A subfamily of the murine I V-region mouse anti-human CD40 G28-5 .1 ..............mkvlsllylltaipgfmsdiqlqqsgpglvkpsqslslt c svt gy sittnynwnwirqfp G28-5 61 gnklewmgyirydgtseytpslknrvsitrdtsmnqfflrltsvtpedtatyy c arldywgqgtsvtvss Hampster hybridoma immunoglobulin heavy chain variable region anti-mouse CD3 receptor 500A2 ...1 ..............mawsciifflvsvitgvhsqvklqqsgselgkpgasvkls c kts gy iftdhyiswvkqkp 1452c11 .1 ..............mnsglqlvffvltlkgiqgevqlvesggglvqpgkslkls c eas gf tfsgygmhwvrqap 500A2 ..61 geslqwignvyggnggtsynqkfqgkatltvdkisstaymelssltsedsaiyy c arrpvatghamdywgqgiqvtvss 1452c11 61 grglesvayitsssinikyadavkgrftvsrdnaknllflqmnilksedtamyy c arfdwdknywgqgtmvtvss Mouse hybridoma variable region of immunoglobulin heavy chain Egtved virus neutralization by anti-G-protein 3F1H10 .1 ..............dvqlqesgpglvkpsqslslt c svt gy sitsgyywnwirqfpgnklewmgyisydgtnny 3F1A2 ..1 ..............dvqlqesgpglvkpsqslslt c svt gy sitsgyywtwirqfpgnklewmgyisydgsnny 1P1H3N .1 ..............qiqlvqsgpelkkpgetvkis c kas gy tftdysmhwvkqapgkglkwmgwintetgesty 3F1H10 61 npslknrisitrdtsknqfflklksvttedtatyy c vrgiyygndwfaywgqgttvtvss 3F1A2 .61 npsltnrisitrdtsknqfflklksvttedtatyy c vrgiyygndwfaywgqgttvtvss 1P1H3N 61 addfkgrfafsletsastaylqinnlrdedtatyf c fgnfdhwgqgttvtvss Human variable immunoglobulin heavy-chain (anti-testosterone) .1 ..............qvqlvqsggglvqpggslrls c aas gf tfssyamswvrqapgkglewvsaisgsggstyy 61 adsvkgrftisrdnskntlylqmnslraedtavyy c akdwrvvpadwgqgtlvtvssgsasapkl Human immunoglobulin heavy chain variable (lymphocte predominant Hodgkins Disease) HSIG448 .1 ..............evqlvqsgaevkkpgeslkis c qgs gy sfnnywivwvrqmpgkglewmgimygrdshtry HSIG504 .1 ..............qeqlvesggglvkpggslrls c tas gf tfsdyymswirqapgkglglisyitssghityy HSIG480 .1 ..............evrllesggdlvqpggslrls c vgs gf ifsnyhlswvrqspgkglewvsivtdhgntkca HSIG473 .1 ..............qvqleqwgagllkpsetlslt c evh gg sfsgyywtwirqppgkglewigevdqsggtkyn HSIG413 .1 ..............qvqlvesggdlvkpggslrls c aas gf tfsdyymtwirqtpgkglewisyisssgytlyy HSIG448 61 spsfqgqvtisvdksintaylqwsslkasdtamyy c arrkewsnwfdpw HSIG504 61 adsvegrfiisrdnaknslylqmntlraedtavyy c arvglaggtyfqfwsgyhedylgmdiw HSIG480 61 .dsvkgrftisrdnskntiylqmhilrpedtavyy c attiveyhtrrsqplehw HSIG473 61 .pslksrvtisidtskrqfslklttftaadtavyy c argqvtlrrggsytfwrgyhedkayydmdvw HSIG413 61 vdsvkgrftisrdnaknslylqmnslraedtaiyy c arilstggg Human IgG heavy chain variable region (somatic hypermutation Bloom's syndrome) derived from Bloom's Syndrome patient 1" Vh6-1 .1 .................pglvkpsqtvslt c ais gd svsgnsaawnwirqspsrglewlgrtyyrskwyndyadsvk Vh6-2 .1 .................pglvrpsqtlslt c gis gd svssnsaswnwlrqspsrglewlgrtyyrskwyndyalsve Vh6-3 .1 .................pglvkpsqtlslt c ais gd svsnnragwnwirqspsgglewlgrtyyrskfysdyaisvk Vh6-1 61 sritinsdtsknqvslqlnsvtpedtavyy c argfapgpyssswyvdywgqgtlvt Vh6-2 61 rrininpdtsknqfslqvnsvtpedtavyy c arvgrigsynygmdvwgqrttvtvssppprahrs Vh6-3 61 sritikpdtsknqislqlnsvtledtavyy c ardqygngwgrrqlvrtpgarepwspspqppprghrs Vh26-1 1 ...............evqllesggglvqpggslrls c aas gf tfnnyamswvrqtpgkglewvssitssasntyh Vh26-2 1 ...............evqllesggglvqpggslkls c aas gf tfssfamswvrqapgkgldwvseisgsggttyy Vh26-3 1 ...............evqllesggglvqpggslrls c aas gf tfssyamswvrqapgkglewvsvisgsggstyy Vh26-4 1 ...............evqllesggglvqpggslrls c aas gf tfssyamnwvrqapgkglewvstisgsgdnthy Vh26-5 1 ...............evqllesggglvqpgrslrls c tas gf tfknyamtwvrqapgkglewvsaitsggttfya Vh26-6 1 ...............evqllesggglvqpggslrls c aas gf tfssyamswvrqapgkglewvsdisgsggstyy Vh26-7 1 ...............evqllesggglvqpggslrls c aas gf tfssfamswvrqapgkgldwvseisgsggttyy Vh26-8 1 ...............evqllesggglvqpggslrls c aas gf tfstyamnwvrqapgkglewvsalsgsggtr Vh26-9 1 ...............evqlldsggssvqpggslrfs c aas gf tfrtfamswvrqapgkglewvagisgstgstny Vh26-1 61 adsvkgrftisrdnskntlflqmnslrgedtavyy c akswvagttwhffdywgqgtlvtvssast Vh26-2 61 agsvkgrftisrdnskntlylqmnsltaedtavyy c akarlypvgasdywg Vh26-3 61 adsvkgrftisrdnskntlylqmnslraedtavyy c atprwdivvvpaalygmdvwg Vh26-4 61 adsvrgrftisrdnskntlslqmnslgaedtavyy c akdlvvvyydssgyshwgqgtlvtvsaast Vh26-5 61 .dslkgrftisrdnskstlyleinslgvedtavyy c atetmttrevqywg Vh26-6 61 adsvkgrftisrdnskntlylqmnsltaedtavyy c akarlypvgasdywgqgtlvtvssast Vh26-7 61 agsvkgrftisrdnskntlflqmnsltaedtavyy c akrfwsgylwfdpwgqgtlvtvssast Vh26-9 61 adsvkgrftisrdnskntlyllmnslraedmavyy c akdlrrdsggkierlgggyfdswgh Human monoclonal cell line 5.G3 immunoglobulin heavy chain variable region anti-streptococcal/anti-myosin 5.G3 .1 ..............qeqlvesggglvkpggslrls c aas gf tfsdyymswirqapgkglewvsyisssssytny 1.C8 .1 ..............qvqlvesgggvvqpgrslrls c aas gf tfsyyvmhwvrqapgkglecvaiisydgsnkyy 1.H9 .1 ..............qvqlvesgggvvqpgrslrls c aas gf tfsnygmhwvrqapgkglewvavisydgsykyy 3.B6 .1 ..............qvqlqesgpglvkpsgtlslt c avs gg sisssnwwswvrqppgkglewigeiyhsgstny 5.G3 61 adsvkgrftisrdnaknslylqmnslraedtavyy c arsstrgsgkrqrtgyyyygmdv 1.C8 61 adsvkgrftisrdnskntlylqmnslraedtavyy c akekpritifgife 1.H9 61 adsvkgrftisrdnskntlylqmnslraedtavyy c akekpritifgife 3.B6 61 npslksrvtisvdksknqfslklssvtaadtavyy c arvgvtggd Mouse antibody heavy chain (IgG2a)variable [anti-HLA-DR] pMEK1HC .1 .......gistqvklvepgaelarwgsvrlsarfwlhfihywiqwvrqrpgqvwnglgyflrcdidl pMEK1HC 61 slrklnvdessrhaymqlrrlasddsavyy c ardmttvvvtgldyspqgttlsqspqpkrhphlsihwplcvemlap Human immunoglobulin heavy chain variable region (HIV-related Burkitt lymphoma) OR .1 ..............lvallrgvqcqvhvvesgggvvqpgrslrls c avs rf ifssydmhwvrqvpgrglewvav TE .1 ..............lvallrgvqcqvhvvesgggvvqpgrslrls c aas rf ifssydmhwvrqvpgrglewvav OR 61 isedgshryyadsvkgrftisrdnsnntlylqissvntedtavyf c ardmgtrfdfwgrgslvtvss TE 61 isedgshkyyadsvkgrftisrdnsnntlylqissvntedtavyf c ardmgtrfdfwgrgslvtvss Human Burkits Lymphoma Ig heavy-chain variable regions BL108 .1 ..............qvqlqqwgagllkpsetlslt c avy gd sftdyywswirqppgkdlewigeinhsgntnyn BL74 ..1.............. rvqlqqwgarvlqpsetlslp c avy gg sfsgyywtwirqppgkglewigeidhsgstnyn BL54 ..1 ..............evhllesggglvqpggslrls c eas gf sfdtyamnwvrqapgkglewvsfispsggttyy BL53 ..1 ..............evqlvesgggliqpggslrls c aas gf tvssnymswvrqapgkglewvsviysggstyya BL47 ..1 ..............qvklvesgggvvqpgrslrls c aas gf nfrnaamhwvrqapgegldwvaiisydgsvmac BL37 ..1 ..............qvqlvqsgaevkkpgasvkvs c kas gy tftdyymhwvrqapgqglewmgwinpnsggtny BL135 .1 ..............qvqlvesggglvqpggslrls c aas gf tvssnymswvrqapgkglewvsviysdgrtyya BL113 .1 ..............eiqlvefggglvqpggslrls c dat gf ifsrhdmiwvrqapgkglewvsyidvsgdrsdy BL79 ..1 ..............evqllesgghlvqpggslrls c aas gf nfsnyvmswvrqapgkglewvadinghggrify BL64 ..1 ..............qvqlvqsgaemkkpgasvkvs c kas gy tftsyywvrqapgqglewmgiinpsggstiyaq BL44 ..1 ..............evqlvesggglvqpggslgls c aas gf tfsiydmkwvrqapgkglewvsyisssgtiiyy BL16 ..1 ..............evqlvesgggvvqpggslrls c aas gf tvssnymtwvrqapgkglewvsliysggtttyy BL108 61 .psltsrvtisvdtsknqfslkmnsvtaadtavyy c arlrqygakaggywgqgtlvtvss BL74 .61 .pslrsrltmsldtsksqfslsltsvtaadtavyy c arkmipgpspfdywgqgtlvtvss BL54 .61 tdsvkgrffisrdnskntlylqmnslraedtaayh c aklghysqfhisyfdywgqgtlvtvss BL53 .61 .dsvkgrftisrdnskntlylqmnslraddtavyy c aglncsgascyptyfyyygmdvwgqgttvtvss BL47 .61 adsvkgrftisrdnsnntlylqmdslrtedtavyf c akdhsetwsldhwgqgtvvtvss BL37 .61 aqkfqggvtmtrdtsittaymelsrlrsddtavyy c ardvipsssnsgsyleywgqgtlvtvss BL135 61 .dsvkgrftisrdnskntlflqmnslraedtavyy c ardpgyyfdsggyrdcfyygldvwgqgttvtvss BL113 61 adsvkgrftisrdnskntvylemnslraedtalyy c akscggddcyegfdywgqgtlvtvss BL79 .61 gdsvkgrftisrdnskntlylqmnslraedtalyy c arraddmmnrpdamdvwgqgttvtvss BL64 .61 ..kfhgrvtmtrdtststvymelsslrsddtavyy c atdysknstrmptfldfrgqgtlvtvss BL44 .61 adsvkgrftisrdkgnnslylqmnslgvedtalyy c ardsqyvpfdywgqgtlvtvss BL16 .61 aesvkgrftisrdnskntmylqmnslrvedtavyy c agdlnstsvgtnnfymdvwgkgttvtvss unidentified species? unamed proteins? HEAVY CHAIN VARIABLE REGION C21-HAY3 1 mdwtwrvfcllavapgahsqvqlvqsgaevkkpgasvkvs c kas gy tfsmywlewvrqapgqrlewmgeispgtf C21-HAY1 1 mdwtwrvfcllavapgahsqvqlvqsgaevkkpgasvkvs c kas gy tfsmywlewvkqrpgqrlewmgeispgtf C21-H3 ..1 mdwtwrvfcllavapgahsqvqlvqsgaevkkpgasvkvs c kas gy tfsmywlewvrqapghglewvgeispgtf C21-H1 ..1 mdwtwrvfcllavapgahsqvqlvqsgaevkkpgasvkvs c kas gy tfsmywlewvkqrpghglewvgeispgtf TES-C21 .1 ...................qvqlqqsgaelmkpgasvkis c ktt gy tfsmywlewvkqrpghglewvgeispgtfttny C21-HAY3 76 ttnynekfkaratftadtsastaymelsslrsedtavyy c arfshfsgsnydyfdywgqgtlvtv ss C21-HAY1 76 ttnynekfkakatftadtsastaymelssltsedtavyy c arfshfsgsnydyfdywgqgtlvtv ss C21-H3 ..76 ttnynekfkaratftadtstntaymelsslrsedtavyy c arfshfsgsnydyfdywgqgtlvtv ss C21-H1 ..76 ttnynekfkakatftadtstntaymelssltsedtavyy c arfshfsgsnydyfdywgqgtlvtv ss TES-C21 .61 ....nekfkakatftadtssntaylqlsgltsedsavyf c arfshfsgsnydyfdywgqgtsltvss Mouse immunoglobulin heavy chain variable region"anti-hepatitis B virus pre-S2 surface antigen .1 ......mylglnyvfivfllngvqsevkleesggglvqpggsmkls c aas gf tfsdawmdwvrqspekglewvgei 71 rskannhatyyaesvkgrftisrddskssvylqmnslraedtgiyy c tpittgawfaywgqgtlvtvsa Human IgE variable region heavy chain-5 1R1" .1 ..............evqlvqsgaevkkpgeslkis c kgs gy sftsywigwvrqmpgkglewmgiiypgdsdtry 61 spsfqgqvtisadksistaylqwsslkasdtamyy c arafdvwgqgtmvtvss mouse Ig heavy-chain S107 derived IgM antibody 1H12 .1 ................melgfswvflvtllngiqcevklvesggglvqpggslrls c ats gf tftdyymswvrqpp 1H12 61 gkalewlgfirnkangytteysasvkgrftisrdnsqsilylqmntlraedsatyy c ardngdydyerfaywgqgtlvtv Mouse sperm immunoglobulin heavy chain V1-region .1 ................mklwlnwvflltllhgiqcevklvesggglvqpggslrls c ats gf tfsdfymewvrqpp 61 gkrlewiaasrnkandytteysasvkgrfivsrdtsqsilylqmnalraedtaiyy c ard mouse immunoglobulin heavy chain variable region germinal center (GC) B cells (4-hydroxy-3-nitrophenyl) acetyl coupled chicken gamma globulin immunized III-18 .1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpksggtkynek d9/9 ...1 ..............lqqpgadlvkpgasvkls c kas gy tftsylmhwvkqrpgrglewigridpnsggtkynek d9/7 ...1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtknnek d9/5 ...1 ..............lqqpgadlvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsgdtrynek d9/4 ...1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek d9/3 ...1 ..............lqqpgaelvkpgasvkls c kas dy tftsywmhwvkqrpgrglewigridpnsggtkynek d9/2 ...1 ..............lqqpgaelvkpgasvkls c kas gy tftsyrmhwmkqrpgrglewigridpnsggtkynek d9/18 ..1 ..............lqqpgaelvkpgasvkls c kas gy tftsylmhwvkqrpgrglewigridpnsggtkynek d9/15 ..1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek d9/13 ..1 ..............lqqpgaelvkpgasvkls c kas gy tftsywihwvkqrpgrglewigridpisagtkynek d9/12 ..1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnssgtkyner d9/11 ..1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek d9/1 ...1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpntggtkyhek 8/23p9 .1 ..............lqqpgaelvkpgasvkls c kas gy tftsylmhwvkqrpgrglewigridpnsggtkynek 8/23p7 .1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek 8/23p3. 1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek 8/23p1 .1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek p9..... 1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek p5 .....1 ..............lqqpgselvkpgasvkls c kas gy tftsywmhwvkqrpgrglewvgridpnsggtkynek p4 .....1 ..............lqqpgaelvkpgasvnls c kas gy tltsywmhwvkqrpgrglewigridpnsgntnynek p3 .....1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek p2 .....1 ..............lqqpgaelvkpgapvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkyneq 8/7p9 ..1 ..............lqqpgaelvkpgasvkls c kas gy tfttywmhwvkqrpgrglewigridpnsggtkynek 8/7p8 ..1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek 8/7p7 ..1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek 8/7p6 ..1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigrigpnsggtkynek 8/7p17 .1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek 8/7p14 .1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek 8/7p13 .1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek 8/7p11 .1 ..............lqqpgaelvkpgtsvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek 8/7p10 .1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtkynek 8/7p1 ..1 ..............lqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrpgrglewigridpnsggtknnek III-18 61 fkskatltvdkpsstaymqlssltsedsavyy c arydygryfdvwgtgttvtvss d9/9 ..61 fkskatltidkpsstaymqlssltsedsavcy c aryfygslfdywgqgttltvss d9/7 ..61 fkskatltvdepsstaymqlssltsedsavyy c arsnypyyfdywgqgttltvss d9/5 ..61 fkskatltvdkpsstaymqlssltsedsavyy c aryyygsifdywgqgttltvss d9/4 ..61 fknkatltvdkpsstaymqlssltseesavyy c arynlllrsmdywgqgtsvtvss d9/3 ..61 fkskatltvdkpsstaymqlssltsedsavyy c arypyyygssyfdywgqgttltvss d9/2 ..61 fkskatltvdkpsstasmqlssltsedsavyy c arykyggamdywgqgtsvtvss d9/18 .61 fkskatltvdkpsstaymqlssltsedsavyy c aryrvayyfdywgqgttltvss d9/15 .61 fktkatltvdkpsstaymqlssltsedsavyy c arygkgyamdywgqgtsvtvss d9/13 .61 fkskailtvdkpsstaymqfssltsedsavyy c arygygssldywgqgtiftvss d9/12 .61 fkskatltvdipsstaymqlssltsedsavyy c arysnyryyamdywgqgtsvtvss d9/11 .61 fkskatltvdkpsstaymqlssltsedsavyy c aryrvayyfdywgqgttltvss d9/1 ..61 fkskatltvdkpsstaymqlssltsedsavyy c alyyygstsfdywgqgttltvss 8/23p9 61 fktkatltvdkpsstaymqlssltsedsavyy c aryyyglyfdywgqgttltvss 8/23p7 61 fkskatltvdkpsstaymqfssltsedsavyy c asyyygsssfdywgqgttltvss 8/23p3 61 fktkatltvdkpsttaymqlssltsedsavyy c aryyygslfdvwgtgttltvss 8/23p1 61 fkskatltvdkpsntaymhlssltsedsavyy c argrlgtlhfdywgqgttltvss p9 ....61 fknkatltvdkpsstaymqlssltsedsavyy c arygtgyamdywgqgtsvtvss p5 ....61 fkskatltvdkpsstaymqlssltsedsavyy c aryllwgamdywgqgtsvtvss p4 ....61 fkskatltvdkpsstaymqlsslisedsavyy c aryyygrgdfdvwgtgttvtvss p3 ....61 fkskatltvdkpsstaymqlssltsedsavyy c aryyygwyfdvwgtgttvtvss p2 ....61 fkskatltvdkpsntaymqlssltsedsavyy c arylysnyfdywgqgttltvss 8/7p9 .61 fksratltvdkpsstaymqlssltsedsavyy c akyyygsssfdywgqgttltvss 8/7p8 .61 fkskatltvdkpsstaymqlssltfedsavyy c aryyyglyfdywgqgttltvss 8/7p7 .61 fkskatltvdkpsstaymqlssltsedsavyy c aryyygssplfdywgqgttltvss 8/7p6 .61 fkskatltvdkpsstaymqlssltsedsavyy c aryplgyamdywgqgtsvtvss 8/7p17 61 fkskatltvdkpsstaymqlssltsedsavyy c aryyyyamdywgqgtsvtvss 8/7p14 61 fkskatltvdkpsstaymqlssltsedsavyy c aryrygysamdywgqgtsvtvss 8/7p13 61 fkskatltvdkpsstaymqlssltsedsavyy c aryyygryfdywgqgttltvss 8/7p11 61 fkskatltvdkpsstaymqlssltsedsavyy c arygrgyamdywgqgtsvtvss 8/7p10 61 fkskatltvdkpsstaymqlssltsedsavyy c aryyygslfdywgqgttltvss 8/7p1. 61 fkskatltvdkpsstaymqlssltsedsavyy c arylracfdywgqgttltvss Chicken Ig heavy-chain variable immunized with mouse serum albumin" D70828 1 ..................altqpasvsanpgetvkit c sgd nn ygwyqqkspgsapvtviyyndkrpsdipsrfsgsk D70827 1 ..................altqpasvsanpgdtvkit c sgg gg ssyygwyqqkspgsapvtviydddkrpsdipsrfs D70826 1 ..................altqpssvsanpgetvkit c sgg gg sygwfqqkspgstpvtviyhddkrpsnipsrfsgs D70825 1 ................avtldesggglqtpggalslv c kas gf dfssyamnwvrqapgkglewvagisaagrttyv D70823 1 ................avtldesggglqtpggalslv c kgs gf tfssyqmlwvrqapgkgleyvaqistvngattr D70821 1 ................avtldesggglqtpggglslv c kas gf sisgysmqwvrqapgkglewvagiysgsspyyg D70820 61 ...............sgstgtltitgvraedeavyy c ggfdgstdtgifgagttltvlk D70827 61 ............gsksgstgtltitgvqaedeavyf c gnkdgsgaafgagttltvlk D70826 61 ..............tsgstatltitgvqaedeavyf c ggsdsaygglfgagttltvlk D70825 61 ..aavdgratisrddgqstvrlqlnnlraedtaiyf c arnrnnvyyyntawidawghgtevivst D70823 61 ygvavkgratisrdngqstvrlqlnnlraedtatyy c trcayggcygaastdawghgtevivst D70821 61 ..aavkgratisrdngqstvrlqlnnlraedtatyy c arspygisgpytaakidawghgtevivst Mouse 4-week-old splenocyte immunoglobulin heavy chain variable region" .1.............. lqqsgpelvkpgpsvkis c kas gy sftgyymhwvkqshgksewigeinpynggtsynqk 61 fkgkatltvdtssstaymelhsltsedslvyy c ar Mouse-immunoglobulin heavy chain in autoimmune-prone mice .1 ..............mgwswiflfllsvtagvfsevqlqqsgpelvkpgasvkis c kas gy sftgyfmnwvkqsh 61 gkslewigrinpyngdtfynqkfkgkatltvdkssstahmelrsltsedsavyy c arlnyrgaywgqgtlvtvsa human hybridoma immunoglobulin lambda and mu chain genes in human lymphoblastoid cells MH-4H7 .1 ................mefglswvflvallrggvqcqvplvesgggvvqpgrslrls c eas gf tfstyamnwvrqa HI-223 .1 ................mefglswiflaailkggvqceeqlvesggglvkpggslrls c aas gf tfsnawmswvrqa MH-4H7 61 pgkglewvavi-sy-dgstiyygdsvkgrftisrdnpqntlylqlnslksedtalyy c vreeyayglgsfdiwgqgtmvtvss HI-223 61 pgkglewvgrilskthhgatdyaapvkgrftiarddskstlylqmnslktedtavyy c ttdaevpriwgqgtmvtvssg MOUSE immunoglobulin heavy chain variable region (anti-carcinoembryonic) .1 ..............qpkllesggdlvkpeaslncs c avs gf pfnryamswvlqtpekrlewvafissddgiayy 61 aeskgyrftisrdnaknilylqmsslrsqdtamyy c arvyyygssyfdywgqgttltvss human immunoglobulin heavy chain variable region VH4 - .1 mlfglswaflftilrgvqyevqlvesggdlvqlwwgggvlrls c aac gf ilrsndmnwah 61 .....................rasrkglewvsyisasggslyy a dkgrftisrdngknmlylqmnslrdedsav Rabbit Ig heavy chain precursor V-A2 & V-A1 regions p-mu-3 .1 ...........metglrwlllvavlkgvqcqsvkesegglfkpmdtltlt c tvs gf slssygvnwvrqapg K-25 ...1 ..............................qsvkesegglfkptdtltlt c tvs gf slsgydmswvrqapgkgle BS-5 ...1 ..............................qsveesggrlvtptpgltlt c tvs gf slssydmgwvrqapgkgle p-mu-3 61 kglewigyigtgtylanwaksrstitsntnentvtlkmtsltgadtatyf c gsganieneffnaiwgpgtlvtvss K-25.. 46 .....wigviyasgstyyatwaksrstitrtsbtvblmdsltaqdtatyf c arghtglsylkssvdvwgpgtlvtvs BS-5 ..46 .....wigiiyasgstyyaswakgrftisktsttvdlktslptedtatyf c arqgtglvhlafvdvwgpgtlvtvs mouse IgG2a heavy chain variable region (anti-arsonate monoclonal antibody 36-60 ..1 .......................evqlqesgpslvkpsqtlslt c svt gd sitsdywnwirkfpgnklehmgyisysgstyyn 93G7 ...1 ....mgwsfiflfllsvtagvhsevqlqqsgaelvragssvkms c kas gy tftsyginwvkqrp g69883 .1 .......................evqlqqsgaelvkagssvkms c kat gy tfssyelywvrqapgqgledlgyissssaypny 36-60 .61 ..........pslksrisitrdtsknqyylqlnsvtsedtatyy c tslrfaywgqgtlvtvsagqglewigyi 93G7 ..71 npgngyinynekfkgkttltvdkssstaymqlrsltsedsavyf c arshyyggsydfdywgqgtpltvss g69883 61 .........aqkfqgrvtitadestntaymelsslrsedtavyf c avrvisryfdgwgqgtlv Mouse myeloma Ig heavy chain V region (anti-dinitrophenyl activity) MOPC 315 .1 ..............mkvlsllylltaipgimsdvqlqesgpglvkpsqslslt c svt gy sitsgyfwnwirqfp MOPC 315 61 gnklewlgfikydgsngynpslknrvsitrdtsenqfflklnsvttedtatyy c agdndhlyyfdywgqgttltvss Human IgG1 HEAVY CHAIN V-II REGION HE... 1 ...................qvtlkengptlvkptetltlt c tls gl slttdgvavgwirqgpgralewlawllywdddk McE.. 1 ...................qitlkesgptlvkptetltlt c tfs gf slstsgvgvgwirqrpgkalewlafinwdddnr Cess .1 mdilcstlllltvpsgvlsqvnlresgpalvkathtltlt c tfs gl svntrgmsvswirqppgkalewlaridwdddkyy HE ..61 ...rfspslksrltvtrdtsknqvvltmtnmdpvdtatyy c vhrhprtlafdvwgqgtkvavss McE. 61 ....yspslrsrltgtkdtsrnqvvltitnmdpvdsgtyf c ahrppwrftgnlggfdxwgqgtlvtvss Cess 81... ..gtsletrltiskdtsknqvvlkvtnmdpadtatyy c armqvtmvrevmitsnafdiwgqgtwspslq human IG HEAVY CHAIN V-I REGION (HG3) HG3 .1 mdwtwrvfcllavapgahsqvqlvqsgaevkkpgasvkvs c kas gy tfnsyymhwvrqapgqglewmgiinpsgg HG3 76 .stsyaqkfqgrvtmtrdtststvymelsslrsedtavyy c ar mouseIgG2a heavy chain V region MOPC173 .1 ..............evkllesggplvqlggslkls c aas gf dfsrywmswvrqapgkglewigeidpnsstiny MOPC173 61 tpslkdkfiisrndakntlylqmskvrsedtalyy c arspyyamnywgqgtsvtvss Mouse Ig heavy chain V region (anti-phosphorylcholine) M603 .1 ................evklvesggglvqpggslrls c ats gf tfsdfymewvrqppgkrlewiaasrnkgnkytt M603 61 eysasvkgrfivsrdtsqsilylqmnalraedtaiyy c arnyygstwyfdvwgagttvtvss Mouse Ig heavy chain V-III region - anti-inulin. ABE-47N .1 ................evkleesggglvqpggsmkls c vas gf tfsnywmnwvrqspekglewvaeirlkshnyat ABE-47N 61 hyaesvkgrftisrddskssvylqmnnlraedtaiyy c stgfaywgqgtlvtv Mouse Ig heavy chain V region 441 .1 ..............mdfgliffivallkgvqcevkllesggglvqpggslkls c aas gf dfsrywmswvrqapg 441 61 kglewigeinpdsstinytpslkdkfiisrdnakntlylqmskvrsedtalyy c ar Mouse Ig heavy chain VH1 regions .1 ................evklvesggglvqpggslrls c ats gf tfsdfymewvrqppgkrlewiaasrnkandytt 61 eysasvkgrfivsrdtsqsilylqmnalraedtaiyy c ardyygssywyfdvwgagttvtvss mouse IgG2a heavy chain V region MOPC21 .1 ..............rlnlvflvlilkgvqcdvqlvesggglvqpggsrkls c aas gf tfssfgmhwvrqapekg MOPC21 61 lewvayissgsstlhyadtvkgrftisrdnpkntlflqmtslrsedtamyy c arwgnypyyamdywgqgtsvtvss Human IgM heavy chain V-I region (anti-gamma globulin) Wol .1 qvqlmqsgaevkkpgssvrvs c kts gg tfvdykglwvrqapgkglewvgqiplrfngevk Sie .1 qvqlvqsgaevkkpgssvrvt c kts gg tfsgytiswvrqapgrglewvgspakwtdpfqg Wol 61 npgsvvrvsvslkpsfnqahmelsslfsedtavyy c areygfdtsdyyyyywgqgtlvtvssgs Sie 61 vyikwervtvslkpsfnqaymelvnlfnedgavyy c arewkgqvnvnpfdywgqgvlvtvssgs Mouse IgG2a heavy chain V region (23) ...23 .1 mgws c iilflvaaangvhsqvqlqqpgtelvkpgasvkls c kas gy tftsywmhwvkqrp ....3 .1 mgws c iilflvatatgvhsqvqlqqpgaelvrpgssvkls c kas gy tftsywmdwvkqrp ..102 .1 mgws c iilflvatatgvhshvqlqqpgaelvkpgasvkvs c kas gy tftsywmhwvkqrp .B1-8 .1 mgws c imlflaatatgvhsqvqlqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrp ..145 .1 mgws c imlflaatatgvhfqvqlqqpgaelvkpgasvkls s kas gy tftsywmhwvkqrp 186-1 .1 mgws c imlflaatatgvhsqvqlqqpgaelvkpgasvkls c kas gy tftsywmhwvkqrp ..S43 .1 mgws c imlflaatatgvhsqvqlqqpgaefvkpgasvkls c kas gy tftsylmhwvnqrp ...23 61 gqglewigninpgnggtnynekfkskvtltvdkssstaytqlssltsedsavyy c ar ....3 61 gqglewigniypsdsethynqkfkdkatltvdkssstaymqlssltsedsavyy c ar ..102 61 gqglewigrihpsdsdtnynqkfkgkatltvdkssstaymqlssltsedsavyy c ai .B1-8 61 grglewigridpnsggtkynekfkskatltvdkpsstaymqlssltsedsavyy c arydyygssyfdywgqgttltvss ..145 61 grglewigridpnsggtkynekfkskatltvdkpsstaymqlssltsedsavyy c ar 186-1 61 grglewigridpnsggtkynekfkskatltvdtssstaymqlhsltsedsavyy c ar ..S43 61 grglewigridpnsggttynehfrskatltidkpsstaymqlssltsedsavyy c aryrlgryfdywgqgttltvss Human IgM heavy chain V region anti-myelin-associated glycoprotein V35 .1 mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tftgyymhwvrqapgqglewmgrinpnsg V35 76 .gtnyaqkfqgrvtstrdtsistaymelsrlrsddtvvyy c ar Mouse immunoglobulin BrE-3 heavy chain BrE-3 .1 ................ivfllkgvqsevkleesggglvqpggsmkls c aas gf tfsdawmdwvrqspekglewvae BRE-3 61 irnkannhatyydesvkgrftisrddsksrvylqmislraedtglyy c tgefanwgqgtlvtvsa Mouse Ig heavy chain V region (anti-proenkephalin) pe22 .1 ..............vklqesggglvkpggslkls c aas gf tfssyamswvrqtpekrlewvatisssgnytyyp pe23 .1 ..............vqlqqsgpelvkpgasvkis c kts gy tftentihwvkqshgkslewigginpnngrtsyn pe25..1 ..............vqlqesgpelvkpgasvris c kts gy tftentlhwvkqshgkslewiggihpknggtnyn pe24 .1 ..............vqlqesggglvkpggslkls c aas gf tfssyamswvrqtpekrlewvatisssgsytyyp pe21 .1 ..............vqlqesggglvkpggslkls c aas rf tfssyamswvrqtpekrlewvatissggsytyyp pe20 .1 ..............vqlqesggglvkpggslkls c aas gf tfstyamswvrqtpekrlewvatissggsytyyp pe2 ..1 ..............vqlqesgaelvkpgasvkls c kas gy tftryymywvkqrpgqglewigeinpsnggtnfn pe19 .1 ..............vklresgpelvkpgasvtis c kts gy tftentlhwvkqshgkslewiggihpknggtnyn pe18 .1 ..............vqlqesgpelvkpgtslris c kts gy tftentlhwvkqshgkslewiggihpknggtnyn pe17 .1 ..............vqlqesgpelvkpgasvris c kts gy tftentlhwvkqshgkslewiggihpknggtnyn pe16 .1 ..............vqlqesgpelvkpgasvris c kts gy tftentlhwvkqshgkslewiggihpknggtnyn pe15 .1 ..............vklqesgpelvkpgasvkis c kts gy tftentmhwvkqshgkslewigginpnngglyyn pe1 ..1 ..............vqlqesgtvlarpgasvkts c kas gy sftsywmhwvkqrpgqglewigaiypgnsdtsyn pe13 .1 ..............vklqesggglvkpggslkfs c aas gf tfssyamcwvrqnpekrlewvatvsssgtytyys pe22 61 dsvkgrftmsrdnakntlylqmsslrsedtamyy c vrlyydydpyvmdfwgqgttvtvss pe23 61 qkfqdkapltvdkasstaymevrsltsedsavyf c argdvaywgqgttvtvss pe25 61 qkfrvratltvdkssstaymdfrsltfedsavyy c argdgaywgqgttvtvss pe24 61 dsvkgrftmsrdnakntlylqmsslrsedtamyy c vrlyydydpyvmdywgqgttvtvss pe21 61 dsvkgrftisrdnakntlylqmsslrsedtamyy c trlyydydpyvmdywgqgttvtvss pe20 61 dsvkgrftisrdnakntlylqmsslrsedtamyy c arlyydydpyvmdywgqgttvtvss pe2 .61 ekfkskatltvdkssstaymqlssltsedsavyy c trgvvasmdywgqgttvtvss pe19 61 qkfkgkatltvdkssstaymdfrsltfedsavyy c argdgaywgqgttvtvss pe18 61 qkfkgkatmtvdkssttaymdfrsltfddsavyy c vrgdgaywgqgttvtvss pe17 61 qkftgkatmtvdkssstaymdfrsltfddsavyy c vrgdgaywgqgttvtvss pe16 61 qkfkgkatmtvdkssstaymdfrsltfddsavyy c vrgdgaywgqgttvtvss pe15 61 qkfkvkatltvdkssstaymelrsltsedsavyy c argdgaywgqgttvtvss pe1 .61 qkfkgkakltavtsastaymelssltnedsavyy c tregyttggdywgqgttvtvss pe13 61 dtvkgrftisrdnakntlylqisslrsedtamyy c vrlyysydgpyamdywgqgttvtvss Mouse Ig heavy chain V region .1 ...............vesgpgilqpsqtlslt c sfs gf slstsnmgvgwirqpsgkglewllhilwndskyynpa 61 lksrltiskdtynnqvflkianvdtadtatyy c arianwdwyfdvwgagttvtvss Mouse Ig heavy chain variable region against dystrophin" .........1 ...........glvkpggslkls c avs gf tfssyamswvrqtpekrlewvasissggrtyyldsvkgrfti MANEX1B .1 ...........glvkpggslkls c avs gf tfssyamswvrqtpekrlewvasinsggrtyypdgvkgrfti ........61 srvrnilylqmnslrsedtamyy c ar gy ygny MANEX1B 61 srvrnilylqmnslrsedtamyy c ar gy ygny Mouse Ig heavy chain V regions fragment anti-arsonate idiotype CR-Id7/14 .1 .............................ssvkls c kts gy tftsyginwvkqrpgqglewigyiypgngytay IF6 .......1 ..............evqlqqsgaelvragssvkvs c kas gy tftsyginwvrqrpgqglewigyinpgnvytky CR-Id7/14 47 neqfkgkatltsdtssstaymqlrsltseds IF6 ......61 nenfkgkttltvdrssstaymqlrgltsedaavyf c arseyygggyaldywgqgtsvtvss Mouse Ig Heavy chain variable (expression by Ly-1 B cells) g110187 1 eivltqspttmaaspgekitit c sas ss issnylhwyqqkpgfspklliyrtsnlasgvp g110185 1 .qmqlqesgpglvkpsqslflt c sit gf pits gy ywiwirqspgkplewmgxithsgxtfy g110184 1 .qmqlqesgpglvkpsqslflt c sit gf pits gy ywiwirqspgkplewmgxixhsgxtfy g110182 1 ..mqlqesgpglvkpsqslflt c sit gf pits gy ywiwirqspgkplewmgxithsgxtfyn g110180 1 ......esgpglvkpsqslflt c sit gf pits gy ywiwirqspgkplewmgxithsgxtfynpslq g110179 1 .......................c sit gf pits gy ywiwirqspgkplewmgyithsgetfynpslqspisit g110178 1 .evqlletggglvqpggsrgls c egs gf tf-s gf wmswvrqtpgktlewigdinsdgsainy g110177 1 .evqlletggglvqpggsrgls c egs gf tf-s gf wmswvxqtpgktlewigdinsdgsainy g110176 1 ...................xls c egs gf tf-s gf wmswxrqtpgktlewigdinsdgsainyapsikdrftifrdndkst g110175 1 .evqlletggglvqpggsrgls c egs gx tf-s gf wmswvrqtpgktlewigdinsdgsainy g110174 1 .evqlletggglvqpggsrxls c egs gx tf-s gf wmswvrqtpgktlewigdinsdgsainy g110173 1 eivltqspttmaaspgekitit c sas ss is-s ny lhwyqqkpgfsxklliyrtsnlasgvp g110187 61 .......arfsgsgsgtsysltigtmeaedvatyy c qqgssiprltfgag g110185 61 npslqsxisitretsknqfflqlnsvttedtamyy c agdrs gy wyfdvwgtg g110184 61 npslqspisitretsknqfflqlnsvttedtamyy c agdrd gy wyfdvwgtg g110182 61 .pslqspisitretsknqfflqlnsvttedtamyy c agdsl gy wyfdvwgtg g110180 61 .....spisitretsknqfflqlnsvttedtamyy c xgdyd gy wyfdvwgtgtxv g110179 51 ...........retsknqfflqlnsvttedtamyy c xgdrg gy wyfdvwgtg g110178 61 apsikdrftifrdndkstlylqmsnvrsedtatyf c mryds ny wyfdvwgtx g110177 61 apsikdrftifrdndkstlylqmsnvrsedtatyf c mrygnywyfdvwgtgtxvtv g110176 61 ..................lylqmsnvrsedtatyf c mrygssywyfdvwgtgtxvtvsx g110175 61 apsikdrftifrdndkstlylqmsnvrsedtatyf c mrygpywyfdvwgtg g110174 61 apsikdrftifrdndkstlylqmsnvrsedtatyf c mrygnywyfdvwgtgtxvt g110173 61 .......arfsgsgsgtsysltigtmeaedvatyy c qqgssipltfga Mouse Ig heavy chain V region (hybridoma Se155-4)anti-Salmonella trisaccharide Se155-4 .1 ..............evqvqqsgtvlarpgasvkms c kas gy tftnywmhwikqrpgqglewigaiypgnsatfy Se155-4 61 nhkfraktkltavtstitaymelssltnedsavyy c trgghgyygdywgqgasltvssak Mouse Ig heavy chain V region (E8)(anti-cytochrome c) E8 .1 ..............evqlqqsgaelvkpgasvkls c tas gf nikdtymhwvkqrpekglewigridpasgntky E8 61 dpkfqdkatitadtssntaylqlssltsedtavyy c agydygnfdywgqgttltvss Mouse Ig heavy chain V region (anti-HIV envelope glycoprotein gp160) MC1 .1 .............dvhlqesgpglvapsqtlsit c tvs gf sltnygihwvrqppgkglewlgvmwaggnsnyn MC1 61 salmsrltiskdnskshvflkmsslqtddsasyy c arddgyssayfdywgqgttltvs Mouse Ig heavy chain V and J regions (anti-steroid antibodies) SCET.M8.1 ...1 ...............qiqlvqsgpelkkpgetvkis c kas gy tftnygm-n wvkqapgkglewmdwintytgepty OHP7D7.2.3 ..1 ...............dvqlqesgpglvkpsqslslt c tvt gy sitsdhvwn wvrqfpgnklewmgyinyrggtgy OHP101.B11.1 1 ...............evqlqqsgpelikpgasmkis c kas gy sftgyvmnwvkqshgqtlewigfinpytgvtgy SCET.M8.1 ...61 addfkgrfafsletsastaylqindlknedtatyf c argnvrvyamdywgqgtsvtvss OHP7D7.2.3 ..61 npslksrisltrdtsknqfflqlnsvttedtatyy c srgnryyyamdywgqgtsvtvss OHP101.B11.1 61 nqkfkakatltvdrssntaqmellsltseasavyy c argglrryamdywgqgtsvsvss MOUSEIg heavy chain V regions anti-fluorescein idiotypes) 5-27 ..1 ...................evnlvesggglvspggdlklv c aas gf dvsdy 12-40 .1 ...................evkldetggglgqpgrpmkqs c vas gf qf 10-25 .1 ...................evkldetggdlvqpgrpmkls c vag gf tfsdy 10-25 .1 mylglscvfivfllkgvqcevkldetggdlvqpgrpmkls c vas gf tfsdywmnwvrqspekglewvgqirnkpynyety 10-25 81 ....ysdsvkgrftisrddskrsvylqmnnlraedmgiyy c tamsygraywghgtlvtvsa MOUSE Ig heavy chain V region (36.1.2D)ANTI-isomaltosyl oligosaccharides 36.1.2D .1 .............qvqlkqsgpslvqpsqslsit c tvs df sltnfgvhwvrqspgkglewlgviwrggntdyn 36.1.2D 61 aafmsrlsitkdnsksqvffkmnslqaddtaiyy c tkegyfgnydyamdywgqgtsvtvss Mouse Ig heavy chain V region (2G8)(anti-phosphotyrosine) 2G8 .1 ..............gsimgvqlqqsgaelvrpgalvkls c kas gf nirdsyihwirqrpeqglewigwidhvnv 2G8 61 ntihdpkfqdkatitadtssntvylqlssltsedtavyy c vkgsspywgqgtlvtvsa Mouse heavy-chain V anti-DNA autoantibodies BV17-45 & BV16-13 BV17-45 .1 ..............evmlvesggalvkpggslkls c vas gf tfsnyamswvrqtpekrlewvaiitpggnniyy BV16-13 .1 ..............qvqlkesgpglvapsqslsit c tvs gf sltnfavhwvrqspgkglewlgviwsdgrtdyn BV17-45 61 ldsvkgrftisrdnardtlylqmsslrsedtaiyy c trsrgaywgqgslvt BV16-13 61 .vpfisrlsiskdnsksqvifkmnslqaddtamyy c arklrrpaawfaswgqgtlvt Human Ig variable region (VDJ) (clone T34-1) human anti-DNA autoantibodies (lupus) T34-1 .1 ......................wlflvailkgvqcevqllesggdlvqpggslrls c vas gf tfsnyamswvrqapgkglew T24-3 .1 ............................iikgvqcqvqlvesggglvksggslrls c aas gf tlssyyvswirqapgk T23-9 .1 ................mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg sissyywswirqpp T21-9 .1 ...............efefglswvflvailegvqcevqlvesggglvqpggslrls c aas gf tfssywmswvrql T20-11 1 ......................agflvailegvqcevqlvesggglvqpggslrls c aas gf tfssywmswvrqapgkglew T34-1 .61 .......vsfisesgsntyyvdsvkgrftisrdnskstlylqmnslraedtavyy c arrtiyggstrrvfawgqgslvtvss T24-3 .51 ...glewvsymsssgrtmyyadsvkgrftisrdnaknslhlqmnslrvedtavyf c arenyydnptmkafdiwgqgtmvtvss T23-9 .61 ..gkglewigyiyysgstnynpslksrvtisvdtsknqfslklssvtaadtavyy c arhnssswygryfdywgqgtlvtvss T21-9 .61 pgkglewvanikqdgsekyyvdsvkgrftisrdnaknslylqmnslraedtavyy c arkragkaafniwgqgtmvtvss T20-11 61 .......vanikqdgsekyyadsvkgrftisrdnskntlylqmnslraedtavyy c akdgegwglyyyygmdvwgqgttvtv.. Human Ig heavy-chain variable VHIII region from a human CD5 positive immunocytoma WHR .1 ..............melglswvflvailegvqceaqlvesggdlvqpggslrls c aas gf tfsdysmswvrqap WHR 61 grglewvatvkddgseryyvdsvkgrftisrdnarkslylqlnsvraedtavyy c a r ggitrfgwwgqgtlvtvss Human Ig heavy chain variable region duplication of the D5 cluster .1 .............mefvlswvflvailkgvqcevqlvqsggglvhpggslrls c ags gf tfssyamhwvrqap 61 gkglewvsaigtgggtyyadsvkgrftisrdnaknslylqmnslraedmavyy c ar rainbow trout immunoglobulin heavy-chain variable (germ-line gene) .1 ..............mrtawtlvlmvvsvksvqgqtltesesvvkkpgeshklt c tys gf ggnnwnawirqapgk 61 glewvsaitssdggstyysqsvqgqftisrdnskqqvylqmnslktedsavyy c ar Mouse Ig heavy chain V region expressed by cells transformed with ts-Abelson murine leukemia virus m+46-12 .1 ..............mdwlwnllflmaaaqtgaqaqiqlvqsgpelkkpgetvkis c kas gy tftnygmnwvkqa m+46-12 61 pgkglkwmgwintytgeptyaddfkgrfafsletsastaylqinnlknedmatyf c argfpwyf Mouse monoclonal antibody heavy-chain variable (anti-glycoprotein H) Mab-115 .1 ...............qvqlqqpgaelvrpgasvkls c kas gy tftsywmnwvkqrpgqglewigmiidpsdseth Mab-115 61 ynqifkdkatltvdkssstaymhlssltsedsavfy c argrndfaywgqgtlvtvsa human immunoglobulin heavy chain locus: clustering of autoantibody-related variable segments Genetic analysis of self-associating immunoglobulin G rheumatoid factors from two rheumatoid synovia implicates an antigen-driven response .1 ..............mdwtwrilflvaaatgahsqvqlvqsgaevkkpgasvkvs c kas gy tftgyymhwvrqap 61 gqglewmgwinpnsggtnyaqkfqgrvtmtrdtsistaymelsrlrsddtavyy c ar Mouse Ig heavy chain precursor V region (anti-dextran) W3129 .1 ..............mdfgliffivallkgvqcevkviesggglvqpggslkls c aas gf dfsrywmswvrqapg W3129 61 kglewigeinpdsstinytpslkdkfiisrdnakntlylqmskvrsedtalyy c arlggdlhyyamdywgqgtsvtvss Mouse Ig heavy chain precursor V region (PAR)from autoimmune-prone mice PAR .1 ..............mgwswiflfllsvtagvfsevqlqqsgpelvkpgasvkis c kas gy sftgfmnwvkqsh PAR 61 gkslewigrinpyngdtfynqkfkgkatltvdkssstahmelrsltsedsavyy c arlnyrgaywgqgtlvtvsa Human Ig heavy chain V-III region (K6H6) K6H6 .1 ................mefglswiflvailkgvqcevrlvesggdlvepggslrvs c evs gf ifskawmnwvrqap K6F5 .1 ................mefglswiflvailkgvhcevrlvesggdlvepegslrvs c evs gf ifskawmnwvrqap K5G5 .1 ................mefglswiflvailkgvqcevrlvesggdlvepggslrvs c evs gf ifskawmnwvrqdp K5C7 .1 ................mefglswiflvailkgvqcevrlvesggdlvepggslrvs c evs gf ifskawmnwvrqap K6H6 61 gkglqwvgqiknkvdggtidyaapvkgrfiisrddskstlylqmnrlkiedtavyy c vgnytgtvdywgqgtlvtvss K6F5 61 gkglqwvgqiknkvdggtidyaapvkgrfiisrddskstlylqmnrlkiedtavyy c vgnytgtvdywgqgtlvtvss K5G5 61 gkglqwvgqiknkvdggtidyaapvkgrfiisrddskstlylqmnrlkiedtavyy c vgnytitidywgqgtlvtvss K5C7 61 gkglqwvgqiknkvdggtidyaapvkgrfiisrddskstvylqmnrlkiedtavyy c vgnytgtvdywgqgtlvtvss Human Ig heavy chain V-I region of cloned heavy and light chains of a human anti-cytomegalo- virus Ab reveal a similarity to human monoclonal rheumatoid factors of the Wa idiotypic family EVI-15 .1 ..............vqsqvqlvqsgaevkkpgssvkvs c kas gg tfssyafswvrqapgqglewmggiipflgt EVI-15 61 thyaqkfqdrvtittdestrtaymelhilrsedtaiyy c ardqslenievvpldpnyfydgmdvwgqgtt vtvss Mouse Ig heavy chain V region G2b, anti-DNA autoantibodies from NZB/NZW F1 mice BV04-01 .1 ................evqpvetggglvqpkgslkls c aas gf sfntnamnwvrqapgkglewvarirsksnnyat BV04-01 61 yyadsvkdrftisrddsqnmlylqmnnlktedtamyy c vrdqtgtawfaywgqgtlvtvsa Human Ig heavy chain V region (anti-myelin-associated glycoprotein) .1 ................evqlvesggglvkpggslrls c aas gf tfssynmnwvrqapgkglewvsssssyifyads .1 ................qvqmvqsgaevkkpgasvkvs c kas gy tftsydinwvrqatgqglewmgwmnpssgntgy .1 ................evqlvesggglvkpggslrls c aas gf tfnnpwmswvrqapgkglewvgrfkrktdggtt .1 ................evhlvesggglvkpggslrls c aas gf tfssawmnwvrqapgkglewvgriksktdggtt 61 .....vkgrftisrdnaknslylqmnslraedtavyy c arageysygfadywgrgtlvtvss 61 ..aqkfkgrvtmtrntsistaymelsslrsedtavyf c aralsigvavirgyyyaldvwgqgttvsvss 61 dyaapvkgrftisrddsentlylqmnslktedtavyy c tterkskvslvrgiiitvrerfdiwgqgtmvtvss 61 dyaapvkggftisrddsqntlylqmislktedtavyy c ttdlrtrdplvgtawgqgtlvtvss Human Ig heavy chain V-1 region (AND)expressed at high frequency in chronic lymphocytic leukemia AND ..1 ..............qvqlvqsgaevkkpgssvkvs c kas gg tfssyaiswvrqapgqglewmggiipifgtany 783 ..1 ..............qvqlvqsgaevkkpgssvkvs c kas gg tfssyaiswvrqapgqglewmggiipifgtany WIL2 .1 ..............qvqlvqsgaevkkpgasvkvs c eas gy tftghymhwvrqapgqglewmgwinpnsggtny NEI ..1 ..............qvqlvqsgaevkkpgssvkvs c kas gg tfssyaiswvrqapgqglewmggiipifgtany AND .61 aqkfqgrvtitadeststaymelsslrsedtavyy c arvsifgvvqhyyyyymdvwglgttvtvss 783 .61 aqkfqgrvtitadeststaymelsslrsedtavyy c aktgilgpyssgwypnsdyyyygmdvwgqgttvt vss WIL2 61 aekfqgrvtitrdtsintaymelsrlrsddtavyy c arasycgydcyyffdywgqgtlvtvss NEI .61 aqkfqgrvtitadeststaymelsslrsedtavyy c argprlladvllwfgelsefdywgqgtlvtvss Human Ig heavy chain V region cDNA sequence from a patient with X-linked agammaglobulinemia .1 .....mdlmckkmkhlwfflllvaaprwvlsqlqlqesgpglvkpsetlslt c tvs gg sissssyywgwirqppg 71 kglewigsiyysgstyynpslksrvtisvdtsknqfslklssvtaadtavyy c arpllwfgelfdywgqgtlvtvss Human Ig heavy chain V region (10P1) 10P1 .1 ..............mdwtwrilflvaaatgahsqvqlvqsaselkkpgasvkvs c kas gy tftsyamnwvrqap 10P1 61 gqglewmgwintntgnptfaqgftgrfvfsldtsvstaylqisslraedtavyy c araytlmmtavthfdfwgqgtlvtvss Mouse Ig gamma-2a chain precursor Lym-1 .1 ...mavlglllclvtfpscvlsqvqlkesgpglvapsqslsit c tis gf sltsygvhwvrqppgkglewlvvi Lym-1 71 wsdgsttynsalksrlsiskdnsksqvflkmnslqtddtaiyy c ashygstlafaswghgtlvtvsaakttaps Human Ig heavy chain V-III region (4B4)of a human anti-Sm autoantibody. 4B4 .1 ................mefgleliflaailkgvqcevqlvesggglvkpggslrls c aas gf tfsnawmswvrqap 4B4 61 gkglewvgriksktdggttdyaapvkgrftisrddskntlylqmnslktedtavyy c ttdslpphrvwgqgtlvtvss Human Ig heavy chain precursor V-II region 71-4 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg svssyywswirqpp 71-2 1 mkhlwfflllvaaprwvlsqvqlqesgpglvkpsetlslt c tvs gg svssgsyywswirq 71-4 61 ..gkglewigyiyysgstnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar 71-2 61 ppgkglewigyiyysgstnynpslksrvtisvdtsknqfslklssvtaadtavyy c ar Human Ig Heavy-chain (anti-PR2 erythrocyte autoantibody) .1 ....mdwtwsilflvaaatgahsqvqlvasgaevnkpgasvkvs c kas gy tftsygiswvrqapgqglewmgwi 71 svyngdtnyaqnlqgrvtmttdtststaymelrnlrsddtavyy c arapgycsgggcyrgddywgqgtlvtvssgsrsaptlfplvs Human IgM monoclonal striational autoantibody heavy chain variable IgM StrAb SA-1A .1 ..............gvcaevqlvqsgaevkkpgeslkis c kgs gy sftsywigwvrqmpgkglewmgiiypgds IgM StrAb SA-1A 61 dtryspsfqgqvtisadksistaylqwsslkasdtamyy c arqsygyydfrsgy ypayyyygmdvwgegttv Mouse Ig heavy chain V region .1 ..............sgasvkls c kas gy tfpsywmnwvkqrpgqglewigmidpsdsethynqmfrdkatltvd 61 kssntaymqlssltsedsavyy c argnygnyayaldywgqgtsvtvss Mouse Ig heavy-chain variable (anti-mouse red blood cell autoantibodies from autoimmune NZB mice 31-9D .1 ................qvtlkesghgvlqpsqtlslt c svs gf slsahnmgvgwirrpsgkglewlaniwwnddky 105-2H 1 ................qvqlqqpgaelvkpggsvrls c kas gy tftsywinwvkqrpgqglewiagiypgststyy 31-9D .61 ynsvlksrltvskdtsnnqvflkissvdttdtatyy c aqiwvgqdwffdvwgagtpvtvss 105-2H 61 .nerfktkatltvdtssshaymqlssltsvdsavyy c arsedydsyvmdwwgqgtsvtvss Mouse Ig heavy chain V region - mouse. 1 ..............qqsgselvrpgasvkls c kas gy tftsywmhwvkqrhgqglewigniypgsgstnydekf 61 kskgtltvdtssstaymhlssltsedsavyy c treeddgygamdywgqgtsvtvss Mouse Ig heavy chain V-D-J region(anti-mouse RBC autoantibodies from autoimmune NZB mice) 4C8 .....1 ..............qvqlqqsgaelvkpgasvkis c kas gy afssdwmnwlkqrpgknlewigqiypgdgdtny 106-10E .1 ..............evqlqqsgpelvksgasvkms c kas gy tftdyymnwvkqshgkslewigrvnpsnggtsy 4C8 ....61 nenfrdkatltadklsstvymqlssltsedsavyf c argdywfpxwgqgtlvtvsa 106-10E 61 nqkfkgkatltvdkslstaymqlnsltsedsavyy c argdywgqgttltvss

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