IgG1 61 . . lyslssvvtvpssslgtqt--y-i c nvnhkpsntkvdkkvepkscdkthtcppcpapellggp
IgG4 61. . glyslssvvtvpssslgtkt--yt- c nvdhkpsntkvdkrveskygppcpscpapeflggpsv
IgG2 61. . glyslssvvtvpssnfgtqt--yt- c nvdhkpsntkvdktverkccvecppcpappvagpsvf
IgE. 61 tlsghyatislltvsga-wakqm--ft- c rvahtpsstdwvdnktfsvcsrdftpptvkilqss
IgD. 61 . dsyymtssqlstplqqwrqge--yk- c vvqhtaskskkeifrwpespkaqassvptaqpqaeg
IgM. 61. rggkyaatsqvllpskdvmqgtdehvv c kvqhpngnkeknvplpviaelppkvsvfvppr
IgA2 61 . gdlyttssqltlpatqcpdg--ksvt c hvkhytnpsqdvtvpcpvpppppcchprlslhrpa
IgA1 61 . gdlyttssqltlpatqclag--ksvt c hvkhytnpsqdvtvpcpvpstpptpspstpptpsp

hinge-Hc2
[IgD 121 slakattapattrntgrggeekkkekekeeqeeretktpecpshtqplgvylltpavqdl]

IgE 121 . . . . . . c dggghfp-ptiqll c lvs gy tpgtinit w ledgqvmdvdlstasttqege
IgM 121 . . . . . . . dgffgnprskskli c qat gf sprqiqvs w lregkqvgsgvttdqvqaeak

IgE 171 . . . lastqseltlsqkhwlsdrtyt c qvtyqghtfeds-tkkcadsnprgvsay
IgM 181 .esgpttykvtstltikesdwlsqsmft c rvdhrgltfqqnassmcvpdqdtairvf

hinge-Hc2/Hc3
IgG1 121 . . .svflfppkpkdtlmisrtpevt c vvvdvshedpevkfnwyvdgvevhnaktkpreeqyns
IgG4 121 . . . flfppkpkdtlmisrt-pevt c vvvdvsqedpevqfnwyvdgvevhnaktkpreeqfnsty
IgG2 121 . . . .lfppkpkdtlmisrt-pevt c vvvdvshedpevqfnwyvdgvevhnaktkpreeqfnstf
IgE. 221 . . . .lsrpspfd-lfi-rksptit c lvvdlapskgtvnltwsrasgkpvnhstrkeekqrngtl
IgD. 181 . . . . assdppeaaswlrdkatft c fvvgsdlkdahltwevagkvptggveegllerhsngsqsq
IgM. 227 . . . .aipps-fasifltkswtklt c lvtdlttyd-svtiswtrqngeav--kthtniseshpn
IgA2 121 . . . . . . . ledlllgseanlt c tltglrdasg-atftwtpssgksavqgpperdl c g c
IgA1 121 .scchprlslhrpaledlllgseanlt c tltglrdasg-vtftwtpssgksavqgpperdl c g c

IgG1 181 . . .tyrvvsvltvlhqdwlngkeyk c kvsnkalpapiektiskakgqprepqvytlppsrdel
IgG4 181 . . . .rvvsvltvlhqdwlngkeyk c kvsnkglpssiektiskakgqprepqvytlppsqeemtk
IgG2 180 . . . .rvvsvltvvhqdwlngkeyk c kvsnkglpapiektisktkgqprepqvytlppsreemtkn
IgE. 279 . . . .tvtstlpvgtrdwiegetyq c rvthphlpralmrsttktsg-praapevyafatpewpgsrdk
IgD. 241 . . . . . hsrltlprslnagtsvt c tlnhpslppqrlmalrepaaqapvklslnll
IgM. 281 . atfsavgeasi c eddwnsgerft c tvthtdlpsplkqtisrpkgvalhrpdvyllppareqlnlre
IgA2 181 . . ysvssvlpg c aqpwnhgetft c taahpelktpltanitk-sgnt-frpevhllpppseelaln
IgA1 183 . . ysvssvlpg c aepwnhgktft c taaypesktpltatlsk-sgnt-frpevhllpppseelaln

Hc3/Hc4
IgG1 241 . . . . . . . . . .tknqvslt c lvk gf ypsdiave w esngqpennykttppvldsdgsfflys
IgG4 241 . . . . . . . . . . .nqvslt c lvk gf ypsdiave w esngqpennykttppvldsdgsffly
IgG2 241 . . . . . . . . . . . qvslt c lvk gf ypsdiave w esngqpennykttppmldsdgsfflys
IgE. 341 . . . . . . . . . . . .rtla c liq nf mpedisvq w lhnevqlpdarhsttqprktkgsgffvf
IgD. 291 . . . . . . . . . . . . wll c evs gf sppnillm w ledqrevntsgfaparpppqpgsttfwaw
IgM. 347 . . . . . . . . . . . satit c lvt gf spadvfvq w mqrgqplspekyvtsapmpepqapgryfahsilt
IgA2 231 . . . . . . . . . . .elvtlt c lar gf spkdvlvr w lqgsqelprekyltwasrqepsqgtttfavtsilr
IgA1 244 . . . . . . . . . . .elvtlt c lar gf spkdvlvr w lqgsqelprekyltwasrqepsqgtttfavtsilrv

IgG1 291 . . . . . .kltvdksrwqqgnvfs c svmhealhnhytqkslslspgk
IgG4 288 . . . . . srltvdksrwqegnvfs c svmhealhnhyt-qkslslslgk
IgG2 288 . . . . . .kltvdksrwqqgnvfs c svmhealhnhyt-qkslslspgk
IgE. 388 . . . . . srlevtraeweqkdefi c ravheaaspsqtvqravsvnpgk
IgD. 338 . . . . . svlrvpappspqpatyt c vvshedsrtllnasrslevsyvtdhgpm...
IgM. 401 . . . . . . . vseeewntgetyt c vvahealpnrvtertvdkstgkptlynvslvmsdtagt c y...
IgA2 287 . . . . . . . vaaedwkkgdtfs c mvghealplaftqktidrlagkpthvnvsvvmaevdgt c y...
IgA1 301 . . . . . . . .aaedwkkgdtfs c mvghealplaftqktidrlagkpthvnvsvvmaevdgt c y...

�

Immunoglobulin Mu heavy-chain (IgM constant regions)

Hv
Human.. 1 . gsasaptlfplvscenspsdtssvavg c laq df lpds-itfs w kyknnsdisstrgfpsvl
Mouse.. 1 . esqsfpnvfplvscesplsdknlvamg c lar df lpst-isft w nyqnnteviqgirtfptl
Possum. 1 . alpsapnlfslspclnsgvedapvavg c lak df lpds-infs w tyqnqsavshtdlkifps
Dog.... 1. . gsasapsifplvscensnptstvamg c lar df lpgs-itfs w kyeblsainstrgfpsvlr
Axolotl 1. . . aaaqapsvypliscgasldpvvig c lak gf lpds-vtfd w tdknnasfsagvaklpsvttg
Pig.... 1 . . . . . . . . . . . . . . . . . . . . . . . . . . . qniqdfpsvlrggky
Chick.. 1. . asaspspprlfplvlcspsdsvytvg c aaf df qpss-iaft w fdsnnssvsgmdvipkvis
Duck... 1 . atprgptlfpllscsssssssslyavg c vav gh vpa-gvtfs w tdvtnatvattivnfpea
Catfish 1 . . vqsapkslfpvwqcgsasdglvtlg c vtr dl asadglsfi w kdasgsaltdvvqypavqa
Salmon. 1 . . asstaptlfplaqcgsgtgdmmtlg c iat gf tpas-ltfk w neqggnsltdfvqypavqts

Human.. 61. rggkyaatsqvllpskdvmqgtdehvv c kvqhpngnkeknvplpviaelppkvsvfvppr
Mouse.. 61 rtggkylatsqvllspksilegsdeylv c kihyggknrdlhvpipavaemnpnvnvfvpp
Possum. 61. qmsgptytatsqvilpaldvlqdsylv c kashlnsnkqvqvslpdttssspnvtvyippr
Dog.... 61 . ggkyvatsqvflpsvdiiqgtdehiv c kvrhsbgbkqkbvplpvmltlppevsgfipprd
Axolotl 61. . . glysastrvkvpseswknrdpyy c kvthpslgqpltkkvqfsvqriskptvtlhapared
Pig.... 16 . . . lassrvllpsvsipqdpeaflv c evqhpsgtksvsisgpvveeqp
Chick.. 61 . . gppyravsriqmnqsegkekqpfr c raahprgnvevsvmnpgpiptpngiplfvtmhpps
Duck... 61 . rgpggnwaasrlelplqegkgrqpfy c raahprgnpvvlavsnpgssqptapvlsihpps
Catfish 61 . . tggytsvshvrvkasdwngnkkft c evknglgskdaslqkpverelhaslllttptqtei
Salmon. 61 . . . gsymgvsqlrvkradwdskife c avehsagsktvpvkkqaeylqhpslyvmtpskeemae

Hc1
Human.. 121 . . . . . . . . . .dgffgnprskskli c qat gf sprqiqvs w lregkqvgsgvttdqv
Mouse.. 121. . . . . . . . . .rdgfsgpaprkskli c eat nf tpkpitvs w lkdgklvesgfttdpvtien
Rat...... 1. . . . . .nvsvfipprdafsgpaprksrli c eat nf spkqitvs w lqdgkpvksgfttepvtveakg
Possum. 121 . . . . . . . . . .dafsnsglrkskli c qvt df rpreiklt w lregrpvssgfstgqvlpdgs
Dog.... 121 . . . . . . . . . . .affgbprksqli c qas gf sprq---v w slrdgkqiesgvttnevzazakzsgp
Axolotl 121. . . . . . . . . . . . .iinnnativ c icr gf hpqpisik w mkngkdvtsgiyteep
Pig..... 61 . . . . .pvlnifvptresfsstpqrtskli c qas df spkqisma w frdgkrvvsgvstapvetlqs
Chick.. 121 . . . . . . . . . .redfegpfrnasil c qtr gr rrpt-evt w ykngspvaaaattattv
Duck... 121 . . . . . . . . . .redfegpyrnssll c rvr gp rgltp-vt w lkngapvtagtvtagsrtdgtg
Catfish 121 . . . . . . . . . . . . .dngtatfv c lat pf spkshtfk w tlektdisnkvkenivsqnkgn
Salmon. 121 . . . . . . . . . . . . . nmtasfa c fan df sprthtik w mrmeqgiekevvsdfkss

Human.. 166. qaeakesgpttykvtstltikesdwlsqsmft c rvdhrgltfqqnassmcvpdqdtairvfaipp
Mouse.. 171. . . kgstpqtykvistltiseidwlnlnvyt c rvdhrgltflknvsstcaaspstdiltftip
Rat..... 61. . . . srpqtykvistltitesdwlnlnvft c rvdhrgltfwknvsstcaaspstdilafpipps
Possum. 171 . . . . . gtyflqssltinesdwlsqstft c rvdhlnaqfqknvssscaistdspieafaipp
Dog.... 171 . . . . . ttykvtsmltiqedawlsqsvft c kvehrgltfqqnassmctsdqpvgisiftipp
Axolotl 181. . . vadtagnfdvtsllniepmdwnmdtvys c vvdqtaskfwntrnmsksmlcdaqvgpvkvt
Pig.... 121 . . . . spvtyrlhsmltvtesewlsqsvft c qvehkglnyeknasslctsnpnspitvfaiapsf
Chick.. 166. . . . . gpevvaesrisvtesewdtgatfs c vvegemrntskrmecglepvvqqdiairvi
Duck... 171. . . . . . ayvtdswlsvteaewdagtvyt c qadgemrnsskslecgldkpdssdiav
Catfish 166. . . . . . ftaisvlelsasewtsstspvk c efqqknhnvfkeasyapgdtkqpqvkitgpst
Salmon. 161 cesekksdktlysttsylrvnesewkseevaft c vfenkagnvrrtvgytssdagpvhahsvvik

Hc2
Human.. 231. . . . . . . . . . sfasifltkstklt c lvtdlttydsvtis w trqngeavkthtniseshpn
Mouse.. 231 . . . . . . . . . psfadiflsksanlt c lvsnlatyetlnis w asqsgepletkikimeshp
Rat.... 121 . . . . . . . . . . fadifltksakls c lvtnlatydtlnis w ssksgepletntkimeshpng
Possum. 227. . . . . . . . . . sfasifvtksaklt c vvtnlptydslsis w trkdgqllktkvkvfsshp
Dog.... 227. . . . . . . . . . sfasifntksakls c lvtdlatydsvtis w treengalkthtniseshp
Axolotl 241. . . . . . . aftvaptfedmfesksanvt c ivtnmgtiegfnit w sredtnevlkteit
Pig.... 181. . . . . . . . . . . agifltksakls c lvtglvtreslnis w trqdgevlktsivfsei
Chick.. 221. . . . . . . . . tpsfvdifisksatlt c rvsnmvnadglevs w wkekggkletalgkrvlq
Duck... 221 . . . . . . . rvlppsfvdifnekvaklt c kvsnlptveglvis w lkedgqkletktmpr
Catfish 206 . . . krengnpefpkvylledilikragqle c raegdtgfks--ik w lignreisslsnlsskttvs
Salmon. 226. . . . . . . . itppsledmlmnkkaelv c dveelvpgfm-svk w endngktltsrkgvtdriaild

Human.. 281 . . . . . atfsavgeasiceddwnsgerft c tvthtdlpsplkqtisrpkgvalhrp
Mouse.. 281. . . . . ngtfsakgvasvcvedwnnrkefv c tvthrdlpspqkkfiskpnevhkhp
Rat.... 171. . . . . . tfsavgvasvcmedwdnrkefv c tvthrdlpspqkkfiskpnevakhppa
Possum. 276. . . . . ngtftaegeatvcaeewnsgeafk c ivthsdhpvplkkeifkpqevdlha
Dog.... 276. . . . . ngtfsamgeatvcveewesgeqft c tvthtdlpsvlkqtisrpkgvavhm
Axolotl 271. . npifhdnatlsvmgiatvcadqwdahhkfv c kvlhqdlaeqrvlslqkpngnqrrkpsvy
Pig.... 226 . . . . yanrafgqgeasvcvedwesgdrft c tvthtdlpsplkqsvskpr
Chick.. 271 . . . . snglytvdgvatvcasewdggdgyv c kvnhpdllfpmeekmrktkasnar
Duck... 271. . . vlqanslygvegvasvcadewnkeevyt c kvshpellfpveeklqkaterdakppalyvf
Catfish 251 . . . . . . . . lqthigfeewingtefi c eveheaftqqyekvtf
Salmon. 281 . . . . . . . . . . ityedwsngtvfy c avdhlenlgslvkkpykretggdpqr

Hc3
Human.. 331 . . . . . . dvyllppareqlnlresatit c lvt gf spadvfvq w mqrgqplspekyvtsapmpepqap
Mouse.. 331. . . . . . pavyllppareqlnlresatvt c lvk gf spadisvq w lqrgqllpqekyvtsapmpepga
Rat.... 221. . . . . . . vyllppareqlilresatvt c lvk gf spadifvq w lqrgqplssdkyvtsapmpepgapg
Possum. 326. . . . . . psvyllhpnpeelslresvtvt c mmk df sppdvfvq w mhkgqpipsekyvtssphqdpqk
Dog.... 326. . . . . . psvyvlppsreqldlresatls c lvt gy sppdvfvq w vqkgqpvppdsyvtsapmpepqa
Axolotl 331. . . . . . . . iypppseelalketativ c lmr gy hpcdlfvr w lensqqlqkqdyvntkqaeevdpttgq
Pig.... 271. . . giarhmpsvyvlppapeelslqewasvt c lvk gf spadvfvq w lqkgepvsadkyvtsapvpepe
Chick.. 321 . . . . . ppsvyvfpppteqlngnqrlsvt c maq gf npphlfvr w mrngeplpqsqsvtsapmaenpe
Duck... 331. . . . . . . . . ppppeqlnahetatvt c lak gf nppdlfir w lrngeplpassyvtmppvaesqlarsyft
Catfish 386 . . . . . . . . . . appessgesvtlt c yvk df ypkevavs w lvndkqveevvgyeqnttavid
Salmon. 321. . . . . . . psvfllapaektsdntvtlt c yvk df ypkevlva w liddepvertsssalyqfnttsqiq

Human.. 391 . . . . . gryfahsiltvseeewntgetyt c vvahealpnrvtertvdkstgkptlynvslvmsdtagtcy
Mouse.. 391. . . . . pgfyfthsiltvteeewnsgetyt c vvghealphlvtertvdkstgkptlynvslimsdtggtcy
Rat.... 281. . . . . . lyfthsiltvteeewnsgetyt c vvghealphmvtertvdkstgkptlynvslimsdtggtcy
Possum. 386. . . . . ggryfsysiltvseaqwnsgdpft c vvahealplsstertvdkstgkptlvnvslvladttntcy
Dog.... 386. . . . . pglyfahsiltvseeewnagetyt c vvaheslpnrvtersvdkstgkptlynvslvlsdtagzcy
Axolotl 391 . . . . . kscfmysmlkipaaqwtagntyt c vvghealplqitqksidrsfgkptkinvslvmsdtanncy
Pig.... 336 . . . pkapasyfvqsvltvsakdwsdgetyt c vvghealphtvtertvdkstgkptlynvslvlsdtastcy
Chick.. 386. . . . . nesyvaysvlgvgaeewgagnvyt c lvghealplqlaqksvdrasgkasavnvslvladsaaacy
Duck... 391. . . . . . . . ysalsvatedwgagnvft c lvgherlplqvaqksvdkssgkptsvnvslvlsdtasscy
Catfish 366 . . . . rnnlfsvysqliiktadwnsgsvfs c lvyhesikdcvrhisrsiakdsktptlvn
Catfish 421 . . . . . . . . . ltltnpqscscstyv c iwsteifhyememdddnmantaltfvflflitlfysigvtvfkvk
Salmon. 381. . . . tgrtysvysqltfsndlwknkevvys c vvyhesmikstkilmrtidrtsnqpylvnlslnvpqsckaq

Immunoglobulin alpha constant regions

Hc1
Human.. IgA1. 1 asptspkvfplslcstqpdgnvvia c lvq gf fpqeplsvt w sesgqgvtarnfppsqdas
Human.. IgA2. 1. sptspkvfplsldstpqdgnvvva c lvq gf fpqeplsvt w sesgqnvtarnfppsqdasg
HUman.. IgA2. 1 asptspkvfplsldstpqdgnvvva c lvq gf fpqeplsvt w sesgqnvtarnfppsqdas
Opossum IgA.. 1 vpktsptvfpmslcdsrtgdsvalg c laq gf fp-epvtls w nyngsegtvrsypamlsgnt
BtPos.. IgA. 61. . . . lfplssfysetsdsivlg c lay rf fp-epvdmt w dysgsggtvrnypamligdaytqasvl
Pig.... IgA.. 1 vsetspkifpltlgssepagyvvia c lvr df fpsepltvt w spsregvivrnfppaqagg
Duck... IgA 121 . . . . . . . . . enrvllv c lie gl qgsn-aqve w linqqvqeleednyscsecsnkk
Dog.... IgA.. 1. sktspsvfplslchqesegyvvig c lvq gf fppepvnvt w nagkdstsvknfppmkaatg

Human.. IgA1 61.gdlyttssqltlpatq c lagksvt c hvkhyt--np-sqdvtvp c pvpstpptpspstpptpsp
Human.. IgA2 61. dlyttssqltlpatq c pdgksvt c hvkhyt--np-sqdvtvp c pvpppppcchprlslhrpal
HUman.. IgA2 61 gdlyttssqltlpatq c pdgksvt c hvkhyt--np-sqdvtvp c pvpppppcchprlslhrpa
Opossum IgA. 61. . ylqtsvldlpanq c peayk-- c gakhyd-t---svdanvp c pvpprpcdcpsgvhvsl
BtPos.. IgA.121 . . . . . dlpadq c sntqaye c qvqhyd-t---sanltvp c kavqdpsq ccsktayvslsppsleslllgt
Pig.... IgA. 61 . lytmssqltlpveq c padqilk c qvqhls-ks--sqsvnvp c kvlpsdpcpqcckpslslqpp
Duck... IgA 166. . atqwsqvnvsrqs w dqgaefs c rvshtslkepivesisty c tsagpklevtllpp
Dog.... IgA. 61. slytmssqltlpaaq c pddssvk c qvqhas--sp-skavsvp c kdnshpchpcpscneprlsl

Hc2
Human..IgA1 121 scchprlslhrpaledlllgseanlt c tltglrdasgvtft w tpssgksavqgpperdlc
Human..IgA2 121 . . . . . . . edlllgseanlt c tltglrdasgatft w tpssgksavqgpperdl
HUman..IgA2 121. . . . . . . ledlllgseanlt c tltglrdasgatft w tpssgksavqgpperd
OpossumIgA. 113. . . . . sgpsleslllgiganlt c tlsgiknsngatft w vhdtaqastlrpiqgapeqds
BtPos..IgA. 181. . . . . . . . . . . ganlt c tlsglksstgveft w artpapastlspiqgtaeq
Pig....IgA. 121 . . . . . . aladlllgsnaslt c tlsglkksegvsft w qpsggkdavqasptr
Duck...IgA. 221 . . . . . . sledlyisqnasvt c vatnap-qd-lkfs w srsegtaldvvtgepqk
Dog....IgA. 121. . . . . qkpaledlllgsnaslt c tlsglkdpkgatft w npskgkepiqknperdscgcysvssvl

Human.. IgA1 181 . . . . . . . gcysvssvlpg c aepwnhgktftctaaypesktpltatlsksgnt
Human.. IgA2 167. . . . . . . cgcysvssvlpg c aqpwnhgetftctaahpelktpltanitksgn
HUman.. IgA2 167 . . . . . . lcgcysvssvlpg c aqpwnhgetftctaahpelktpltanitksg
Opossum IgA 167 . . . . . . . ngkyrvssvlei c teewlrgdtfsctvshseietttktiykpkv
BtPos.. IgA 221 . . . . . . dssgkysvssvlei c teewirgdvfsctvshpeietttktiykpk
Pig.... IgA 166 . . . . . . dscgcysvssilpg c adpwnkgetfsctaahselksaltatitkp
Duck... IgA 266 . . . . . . qenglyrltsvlki c aeewnsgesftcgvagpeiqgsvtksvqkd
Dog.... IgA 181 . . . . . . pgcadpwnhgdtfs c tathpeskspitvsitkttehippq

Hc3
Human..IgA1 226 . . frpevhllpppseelalnelvtlt c lar gf spkdvlvr w lqgsqelprekyltwasrqep
Human..IgA2 211. . tfrpevhllpppseelalnelvtlt c lar gf spkdvlvr w lqgsqelprekyltwasrqe
HUman..IgA2 211 . ntfrpevhllpppseelalnelvtlt c lar gf spkdvlvr w lqgsqelprekyltwasrqepsqg
OpossumIgA 211. . pqippqiyllapsadeqalnemvsit c lvr gf spedvfir w lkgseelpkkdyitsnpyp
BtPos..IgA 267 . vtqippqvyvlppsadelalnelvtiv c lvr gh spqealvq w mngseklpredyitsdphpeprg
Pig....IgA 211. kvntfrpqvhllpppseelalnelvtlt c lvr gf spkdvlvr w lqggqelprdkylvweslpepgqaipt
Duck...IgA 311 lavsvqapsvyvfpppaeelarqetatlt c las gf rprdilvt w tqqdrpvasgsfstfgpqegeaglfs
Dog....IgA 221. . . . . vhllpppseelalnelvtlt c lvr gf kpkdvlvr w lqgtqelpqekyltweplkepdqtn

Human. IgA1 276. sqgtttfavtsilrvaaedwkkgdtfs c mvghealplaftqktidrlagkpthvnvsvvmaevdgtcy
Human. IgA2 271 psqgtttfavtsilrvaaedwkkgdtfs c mvghealplaftqktidrlagkpthvnvsvvmaevdgtcy
HUman. IgA2 276 . . tttfavtsilrvaaedwkkgdtfs c mvghealplaftqktidrlagkpthvnvsvvmaevdgtcy
OpossumIgA 271. epkststymvssilqvqstdwknenkys c vvghealplnftqqtidrlcgkptnvnvsvimsdiygtcy
BtPos. IgA 331. . . tntfiissilqvsasewkaenkys c vvghealplnftqqtidrfsgkptnvnvsvimsdvsgtcy
Pig... IgA 281 . . . . yavtsvlrvdaedwkqgdtfs c mvghealplaftqktidrlagkpthvnvsvvmaeaegicy
Duck.. IgA 381 . . . . . vysklsvaaaewqrgdvfa c vvghdgiplnfvqksldkstgkptqvnvsvvlsdadstcy
Dog... IgA 281. . . . mfavtsmlrvtaedwkqgekfs c mvghealpmsftqktidrlagkpthvnvsvvmaevdgicy

�

Immunoglobulin Epsilon heavy-chain constant region

Hc1
Human IgE.. 1 astqspsvfpltrccknipsnatsvtlg c lat gy fpepvmvt w dtgslngttmtlpattl
Dog.. IgE.. 1 . tsqdlsvfplascckdniastsvtlg c lvt gy lpmsttvt w dtgslnknvttfpttf
Rat.. IgE 141. ssvsvkapslyplkpcssentasvtlg c lvk dy fpdpvtvt w ysdslntstmnfp

Human IgE. 61 . . tlsghyatislltvsgawakqmft c rvahtpsstdwvdnktfsvcsrdft
Dog.. IgE. 68. . hetyglhsivsqvtasgkwakqrft c svahaestainktfsacalnfi
Rat.. IgE 196 . . sigsdlktttsqmtswgksaknft c hvthapstfvsdltirarpv

Hc2
Human IgE 111 . pptvkilqss c dggghfpptiqll c lvs gy tpgtinit w ledgqvmdvdlstasttqege
Dog.. IgE 106 . pptvklfhss c npvgdthttiqll c lis gy vpgdmevi w lvdgqkatnifpytap
Rat.. IgE 241 nitkptvdllhss c dpnafhstiqly c fvy gh iqndvsih w lmddrkiyethaqnvlike

Human IgE 171 . . . lastqseltlsqkhwlsdrtyt c qvtyqghtfedstkk c adsnprgvsay
Dog.. IgE 161 gtkegnvtsthselnitqgewvsqktyt c qvtyqgftfkdeark c sesdp
Rat.. IgE 301. . egklastysrlnitqqqwmsestft c kvtsqgenywahtrr c sddeprgv

Hc3
Human IgE 221 . . . . lsrpspfd-lfi-rksptit c lvvdlapskgtvnlt w srasgkpvnhstrkeekqrngtl
Dog.. IgE 211 . . rgvtsylsppspldlyvhkapkit c lvvdla-tmegmnlt w yreskepvnpgplnk
Rat.. IgE 351. . . . itylippspldlyengtpklt c lvldleseenitvtwvrerkksigsasqrstkhhnatt

Human IgE 279 . . . . tvtstlpvgtrdwiegetyq c rvthphlpralmrsttktsg-praapevyafa
Dog.. IgE 276 kdhfngtitvtstlpvntndwiegetyy c rvthphlpkdivrsiakapgkrappd
Rat.. IgE 411 . . . . sitsilpvdakdwiegegyq c rvdhphfpkpivrsitkapgkrsapevyv

Hc4
Human IgE 331 . . . . . . . tpewpgsrdkrtla c liq nf mpedisvq w lhnevqlpdarhsttqprktkgs
Dog.. IgE 321 . . . . vylflppeeeqgtkdrvtlt c liq nf fpadisvq w lrndspiqtdqytttgphkvsgsrp
Rat.. IgE 481. . . . . . . flppeeeekdkrtlt c liq nf fpedisvq w lqdsklipksqhstttplkyngsnq

Human IgE 383 . . . gffvfsrlevtraeweqkdefi c ravheaaspsqtvqravsvnpgk
Dog.. IgE 381 . . . affifsrlevsrvdweqknkft c qvvhealsgsrilqkwvsktpgk
Rat.. IgE 516 . . . rffifsrlevtkalwtqtkqft c rvihealreprklertiskslgntslrpsqasm

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Immunoglobulin Delta heavy-chain constant region

Hc1
Human IgD .1 . .aptkapdvfpiisgcrhpkdnspvv-la c lit gy hpts-vtvt w ymgtqsqpqrtfpeiqrr
Human IgD 61 . . .dsyymtssqlstplqqwrqge--yk- c vvqhtaskskkei-fr w pespkaqassvptaqpqaegslakattapa

Human IgD 131 ..................ttrntgrggeekkkekekeeqeeretktpecpshtqplgv
. . . . . . 1 kdeyitilqvsvpapnlspnltctitntskkksktfklpetrnsqsskkanptpqaknhymdpinfvtaq

Hc2
Human IgD 171 .ylltpavqdlassdppeaaswlrdkatft c fvvgsdlkdahltwevagkvptggveegll
Human IgD 231 . .erhsngsqsqhsrltlprslnagtsvt c tlnhpslppqrlmalrepaaqieatkptatknivgamapsnlnvni

Hc3
Human IgD 281. . . . . . . . . apvklslnllwll c evs gf sppnillm w ledqrevntsgfaparppp
. . . . . .86. . . . . . .. . lttfthhqmsswlm c evs gf ypedihlw w lsaqtkgcyhllpesdgpprrpdgpafp

Human IgD 348. . qpgsttfwawsvlrvpappspqpatyt c vvshedsrtllnasrslevsyvtdhgpm...
. . . . . 131 .pvrqsgdkfqiwsvlrlpvalspsldtyt c vveheasqtklnasksleis

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Mouse engineered catalytic antibody heavy-chain variable-constant

Hv
48G7 . 1 . . . . . . . qvqlqqsgaelvkpgasvkls c tas gf nikdtymhwvkqrpeqglewigridpangntky
48G7 .61 dpkfqgkatitadtssntaylqlssltsedtavyy c asyygiywgqgttltvssastkgp

Hc1
48G7 121 . . . . . . . .svfplapsskstsggtaalg c lvk dy fpepvtvswnsgaltsgvhtfpavlqssglysls
48G7 181 . . . . . . . . . .svvtvpssslgtqtyi c nvnhkpsntkvdkkvepksc

Mouse IgG Fab Fragment (Cd25-Binding)

Hv
Sdz Chi621 . 1 . . . . . . . qlqqsgtvlarpgasvkms c kas gy sftrywmhwikqrpgqglewigaiypgnsdtsynq
Sdz Chi621 .61 kfegkakltavtsastaymelsslthedsavyy c srdygyyfdfwgqgttltvssastkg

Hc1
Sdz Chi621 121 . . . . . . psvfplapsskstsggtaalg c lvk dy fpepvtvswnsgaltsgvhtfpavlqssglysl
Sdz Chi621 181 . . . . . . . . ssvvtvpssslgtqtyi c nvnhkpsntkvdkrvep

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Spotted Ratfish Distinct patterns of Ig Heavy constant regions

Hc1
AF003847 . 1 . .vdhtkqpsvyillpsaaeltaqqsvtlt c lvk df apkeifvqwtvddkeidvsnykntel
AF003846 . 1 .dcedptgnvkiyflplspkqvlmessvtlt c vvd na pldvnvswtqgekqlsgygkpsvt
AF003845 . 1 vdeiqepsppvviltqpspediaihkpgiav c lis gf rpdeltvkwlkdwepitsgvets

AF003847 .61 . madsadrnysmysmltisagewgrgfsys c ivghetfalktltrtvnkssgkpsfvnislvlmdavnacq
AF003846 .61 . . . . erhevmselnvstedwksgkeff c vashedmptpvrekifqrt
AF003845 .61 .psvkedngtfttssrltvlarewrsgsvyt c qvshsptqtyivknitkss

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Hornshark IG HEAVY CHAIN C REGION, (SECRETED FORM 3050S) Membrane-bound 3050MB)

Hc1
3050S. . 1 atpspptlyglcsceqpntdgslayg c lam dy ipqitsvs w kkdnepittglktypsvln
3050MB . 1 atpspptlyglcsceqpntdgslayg c lam dy ipqitsvs w kkdnepittglktypsvln
6121 . . 1 epittglktypsvln
12022 . .1 atpspailyglcsceqtntdgslayg c lam dy speitsit w kkdkepittglkiypsvln

3050S . 61 . kkgtytqssqltitesevgsskiy c evrrgesvwikeipdckgdkvhptviltqssseei
3050MB. 61 . kkgtytqssqltitesevgsskiy c evrrgesvwikeipdckgdkvhptviltqssseei
6121. . 16 . kkgtytqssqltitesevgsskiy c evrrgesvwikeipdckgdkvhptviltqssseei
12022. .61 . kkgtytrssqltitesevgsskiy c evrrgeslwikeildckgdivpptviltqssseei
6125 . . 1 . . . . . sqltitdsevgsskiy c evrrgeslwikeipdckgdivhptviltqtsseei

Hc2
3050S. 121. . . . . . . . . tsrrfatvl c sii df hpesitvs w lkdgqhmesgfvtsptcgvngtfsatsrltvparew
3050MB 121. . . . . . . . . tsrrfatvl c sii df hpesitvs w lkdgqhmesgfvtsptcgvngtfsatsrltvparew
6121. . 76. . . . . . . . . tsrrfatvl c sii df hpesitvs w lkdgqhmesgfvtsptcgvngtfsatsrltvparew
12022. 121. . . . . . . . . tsrrfatvl c sii df hpesitvs w lkdgqpmdsgfvtsptcevngnfsatsrltvpagew
6125. . 53. . . . . . . . . tssrfatvv c sii df hpeaitvn w lkdghpmesgfvtspacetngnfsatsrltvparew

3050S. 181. . . . . . . . . . ftnkvyt c qvshqgvtqsrnitgsqvpcscndpvikllp
3050MB 181. . . . . . . . . . ftnkvyt c qvshqgvtqsrnitgsqvpcscndpvikllp
6121 . 136. . . . . . . . . . ftnkvyt c qvshqgvtqsrnitgsqvpcscndpvikllp
12022. 181. . . . . . . . . . fsntvyt c qvahqevtqsrnitgsqvpcsigdpvikllp
6125. 113. . . . . . . . . . ftntvyt c qvshqaatqsrnitgspdssecnhpaikllp

Hc3
3050S. 220. . . . . . psieqvlleatvtlt c vvsnapygvnvs w tqeqkslkseiavq
3050MB 220. . . . . . psieqvlleatvtlt c vvsnapygvnvs w tqeqkslkseiavq
6121 . 175. . . . . . psieqvlleatvtln c ivsnapygvnvs w tqeqkslkseiavq
12022. 220. . . . . . psieqvlleatvtlt c vvsnapygvnvs w tqekkplkseiavq
6125 . 152. . . . . . psieqvlleatvtlt c vvsnapygvnvs w tqeqkplkseiavq

3050S. 263 pgedadsvistvnistqawlsgaefy c vvnhqdlptplrasihkeevkdlrep
3050MB 263 pgedadsvistvnistqawlsgaefy c vvnhqdlptplrasihkeevkdlrep
6121 . 218 pgedadsvistvnistqawlsgaefy c vvnhqdlptplrasihkeevkdlrep
12022. 263 pgedsdsvistvnistqawlsgaefy c vvshqdlptplrasihkeevkdlrep
6125 . 195 pgedpdsvistvdistqawlseavfy c vvshqdlptplrdsihkeawkdlrep

Hc4
3050S. 316 . . .svsillspaedvsaqrflslt c lvr gf fpreifvk w tvndksvnpgnykntevmaendns
3050MB 316 . . .svsillspaedvsaqrflslt c lvr gf fpreifvk w tvndksvnpgnykntevmaendns
6121 . 271 . . .svsillspaedvsaqrflslt c lvr gf spreifvk w tindksvnpgnykntevmaendns
12022. 316 . . .fvsvllppaedvsaqrflslt c lvr gf spreifik w tvndksvnpgnykntevmaendnr
6125 . 248 . . .svsvllppaeeisaerflslt c lvr gf spreifvk w tvndksvnpgnykntevmaendks

3050S. 376 . . syfiysllsiaaeewasgasys c vvgheaiplkiinrtvnkssgkpsfvnislalldtvnscq
3050MB 376 . . syfiysllsiaaeewasgasys c vvgheaiplkiinrtvnkssdssdhiwiedneeesaidnas
6121 . 331 . . syfiysllsiaaeewasgasys c vvgheaiplkiinrtvnkssgkpsfvnislalldtvnscq
12022. 376 . . sffiysllsiaaeewasgasys c vvgheaiplkiinrtvnkssgkpsfvnislalldtvnscq
6125 . 308 . . sffiysllsiaaeewasgasys c vvgheaiplkiinrtvnkssgkpsfvnisl alldtvnscq

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Immunoglobulin Gamma chains (Heavy chains)

Hc1
Human. IgG1 . 1 . stkgpsvfplapsskstsggtaalg c lvk dy fpepvtvs w nsgaltsgvhtfpavlqssg
Mouse. IgG1 121 . . ...svyplapgsaaqtnsmvtlg c lvk gy fpepvtvt w nsgslssgvhtfpavlqsdl
Human. IgG2 . 1. astkgpsvfplapcsrstsestaalg c lvk dy fpepvtvs w nsgaltsgvhtfpavlqss
Mouse. IgG2a. 1. akttapsvyplapvcgdttgssvtlg c lvk gy fpepvtlt w nsgslssgvhtfpavlqsd
Mouse. IgG2b. 1. akttppsvyplapgcgdttgssvtlg c lvk gy fpesvtvt w nsgslsssvhtfpallqsg
Mouse. IgG2c. 1. akttapsvyplapvcggttgssvtlg c lvk gy fpepvtlt w nsgslssgvhtfpallqsg
Rat. . IgG2c. 1. arttapsvyplvpgcsgtsgslvtlg c lvk gy fpepvtvk w nsgalssgvhtfpavlqsg
Human. IgG3b. 1. astkgpsvfplapcsrstsggtaalg c lvk dy fpepvtvs w nsgaltsgvhtfpavlqss
Human. IgG4 . 1. astkgpsvfplapcsrstsestaalg c lvk dy fpepvtvs w nsgaltsgvhtfpavlqss
Rabbit IgG. . 1. gqpkapsvfplapccgdtpsstvtlg c lvk gy lpepvtvt w nsgtltngvrtfpsvrqss
Bovine IgG1 141 sasttapkvyplssccgdkssstvtlg c lvs sy mpepvtvt w nsgalksgvhtfpavlqs
Bovine IgG2 . 1. asttapkvyplssccgdksssgvtlg c lvs sy mpepvtvt w nsgalksgvhtfpavlqss

Human. IgG1. 61 . . . lyslssvvtvpssslgtqtyi c nvnhkpsntkvdkkvepkscdkthtcppcpapellggp
Mouse. IgG1 176. . . . ytlsssvtvpssprpsetvt c nvahpasstkvdkkivprdcgckpcictvpevssvfifp
Human. IgG2. 61. . . glyslssvvtvpssnfgtqtyt c nvdhkpsntkvdktverkccvecppcpappvagpsvf
Mouse. IgG2a 61 . . . lytlsssvtvtsstwpsqsit c nvahpasstkvdkkieprgptikpcppckcpapnllgg
Mouse. IgG2b 61 . . . lytmsssvtvpsstwpsqtvt c svahpassttvdkklepsgpistinpcppckechkcpa
Mouse. IgG2c 61 . . . lytlsssvtvtsntwpsqtit c nvahpasstkvdkkieprvpitqnpcpplkecppcaap
Rat. . IgG2c 61 . . . lytlsssvtvpsstwssqtvt c svahpatksnlikrieprrpkprpptdicscddnlgrp
Human. IgG3b 61 . . .glyslssvvtvpssslgtqtyt c nvnhkpsntkvdkrvelktplgdtthtcprcpepksc
Human. IgG4. 61 . . .glyslssvvtvpssslgtktyt c nvdhkpsntkvdkrveskygppcpscpapeflggpsv
Rabbit IgG . 61 . . .glyslssvvsvtsssqp---vt c nvahpatntkvdktvapstcskptcpppellggpsvfifp
Bovine IgG1 201 . . sglyslssmvtvpgstsg-qtft c nvahpasstkvdkavdptckpspcdccpppelpggps
Bovine IgG2. 61 . . .glyslssmvtvpasssgtqtft c nvahpasstkvdkavgvssdcskpnnqhcvrepsvfi

Human IgG3b 121 dtpppcprcpepkscdtpppcprcpepkscdtpppcpr c pap el lggpsv

Hc2
Human. IgG1. 121 . . . .svflfppkpkdtlmisrtpevt c vvvdvshedpevkfn w yvdgvevhnaktkpreeqyns
Mouse. IgG1. 236 . .. . . . . pkpkdtllitvtpkvt c vvvdiskddpevqfs w fvdnvevhtaqtqpreeqfnst
Human. IgG2. 121 . . . . . lfppkpkdtlmisrtpevt c vvvdvshedpevqfn w yvdgvevhnaktkpreeqfnstfr
Mouse. IgG2a 121 . . . psvfifppkikdvlmislspivt c vvvdvseddpdvqis w fvnnvevhtaqtqthredyn
Mouse. IgG2b 121 pnleggpsvfifppnikdvlmisltpkvt c vvvdvseddpdvqis w fvnnvevhtaqtqthredynstir
Mouse. IgG2c 121 .dllggpsvfifppkikdvlmislspmvt c vvvdvseddpdvqis w fvnnvevhtaqtqthredynstlrv
Rat. . IgG2c 121 . . . .svfifppkpkdilmitltpkvt c vvvdvseeepdvqfs w fvdnvrvftaqtqpheeqlng
Human. IgG3b 171 . . . . .flfppkpkdtlmisrtpevt c vvvdvshedpevqfk w yvdgvevhnaktkpreeqynstf
Human. IgG4. 121 . . . . .flfppkpkdtlmisrtpevt c vvvdvsqedpevqfn w yvdgvevhnaktkpreeqfnsty
Rabbit IgG . 121 . . . . . . .pkpkdtlmisrtpevt c vvvdvsqddpevqft w yinneqvrtarpplreqqfnstirvvs
Bovine IgG1. 261 . . . . vfifppkpkdtltisgtpevt c vvvdvghddpevkfs w fvddvevntattkpreeqfnstyrvvs
Bovine IgG2. 121 . . . . . .fppkpkdtlmitgtpevt c vvvnvghdnpevqfs w fvddvevhtartkpreeqfnstyrv

Human. IgG1. 181 .tyrvvsvltvlhqdwlngkeyk c kvsnkalpapiektiskakgqprepqvytlpp
Mouse. IgG1. 291 . frvvsalpimhqdwlngkefk c rvnsaafpapiektisktkgkprapqvytipp
Human. IgG2. 181 . . vvsvltvvhqdwlngkeyk c kvsnkglpapiektisktkgqprepqvytl
Mouse. IgG2a 181 stlrvvsalpiqhqdwmsgkefk c kvnnkdlpapiertiskpkgsvrapqvyvlp
Mouse. IgG2b 191 . . vvstlpiqhqdwmsgkefk c kvnnkdlpspiertiskikglvrapqvyil
Mouse. IgG2c 191 . . .vsalpiqhqdwmsgkefk c kvnnralpspiektiskprgpvrapqvyvlp
Rat. . IgG2c 181 .tfrvvstlhiqhqdwmsgkefk c kvnnkdlpspiektiskprgkartpqvytipp
Human. IgG3b 251 . .rvvsvltvlhqdwlngkeyk c kvsnkalpapiektisktkgqprepqvyt
Human. IgG4. 181 . .rvvsvltvlhqdwlngkeyk c kvsnkglpssiektiskakgqprepqvyt
Rabbit IgG.. 181 . . . .tlpithqdwlrgkefk c kvhnkalpapiektiskargqplepkvy
Bovine IgG1. 326 . . . .alriqhqdwtggkefk c kvhneglpapivrtisrtkgparepqvy
Bovine IgG2. 181 . . .vsalpiqhqdwtggkefk c kvnikglsasivriisrskgparepq

Hc3
Human. IgG1. 236 . . . srdeltknqvslt c lvk gf ypsdiave w esngqpennykttppvldsdgs
Mouse. IgG1. 345. . . .pkeqmakdkvslt c mit df fpeditve w qsdgqapenykntqpimdtdgsyfvy
Human. IgG2. 231. . .ppsreemtknqvslt c lvk gf ypsdiave w esngqpennykttppmldsdgsffl
Mouse. IgG2a 236. . . ppeeemtkkqvtlt c mvt df mpediyve w tnngktelnykntepvldsdgsyfmy
Mouse. IgG2b 241. . .pppaeqlsrkdvslt c lvv gf npgdisve w tsnghteenykdtapvldsdgsyfi
Mouse. IgG2c 241. . . ppaeemtkkefslt c mit gf lpaeiavd w tsngrteqnykntatvldsdg
Rat. . IgG2c 236. . . .preqmsknkvslt c mvt sf ypasisve w erngeleqdykntlpvldsdes
Human. IgG3b 281. . lppsreemtknqvslt c lvk gf ypsdiave w essgqpennynttppmlds
Human. IgG4. 231. . lppsqeemtknqvslt c lvk gf ypsdiave w esngqpennykttppvldsdgsff
Rabbit IgG . 226 . tmgppreelssrsvslt c min gf ypsdisve w ekngkaednykttpavldsdgsy
Bovine IgG1. 371 . vlappqeelskstvslt c mvt sf ypdyiave w qrngqpesedkygttppq
Bovine IgG2. 226 vyvldppkeelskstvslt c mvi gf ypedvdve w qrdrqtesedkyrttppqlda

Human. IgG1. 286. . . .fflyskltvdksrwqqgnvfs c svmhealhnhytqkslslspgk
Mouse. IgG1. 399. . . . . .sklnvqksnweagntft c svlheglhnhhtekslsh
Human. IgG2. 286. . . . . yskltvdksrwqqgnvfs c svmhealhnhytqkslslspgk
Mouse. IgG2a 291. . . . . .sklrvekknwvernsys c svvheglhnhhttksfsrtpgk
Mouse. IgG2b 296. . . . . ysklnmktskwektdsfs c nvrheglknyylkktisrspgk
Mouse. IgG2c 291. . . syfmysklrvqkstwergslfa c svvheglhnhlttktisrslgk
Human. IgG3b 331. . dgsfflyskltvdksrwqqgnifs c svmhealhnrftqkslslspgk
Rat. . IgG2c 286. . . .yflysklsvdtdswmrgdiyt c svvhealhnhhtqknlsrspgk
Human. IgG4. 286. . . . .lysrltvdksrwqegnvfs c svmhealhnhytqkslslslgk
Rabbit IgG.. 281. . . . flynklsvptsewqrgdvft c svmhealhnhytqksisrspgk
Bovine IgG1. 421 ldadssyflysklrvdrnswqegdtyt c vvmhealhnhytqkstsksagk
Bovine IgG2. 281. . drsyflysklrvdrnswqrgdtyt c vvmhealhnhymqkstsksagk

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Xenopus laevis Ig heavy chain C region" *point mutation

Hv
Xl1 1 vtasapsvfplipccdnvdfndsvtmg c lvt gy madpldiqwndgsittgiktmrpvlsd
Xl2 1 vtasapsvsplipccdnvdfndsvtmg c lvt gy dadpldiqwndgsittgiktmrpvlsd

Xl1 61 . vdglytlssqltilasewknstyk c kvvhnytntkqekslkvlpcmaphvqlflqspcms
Xl2 61 . vdglytlssqltilasewknstyk c kvvhnytntkqekslkvlpcmaphvqlflqspcms

Hc1
Xl1 121 . . . .daisraqheninatldll c iin nf yhgqikvkwlvngkqdvsaeasvptpsktedgtyss
Xl2 121 . . . .daisraqheninatldll c iin nf yhgqikvkwlvngkqdvsaeasvptpsktedgtyss

Xl1 181 . . . .ssqlrilkgmwnkgtqys c ivthtssntttianisqcteqchdnlqvypl
Xl2 181 . . . .ssqlrilkgmwnkgtqys c ivthtssntttianisqcteqchdnlqvypltptfhdlyfs

Hc2
Xl1 231 . . . . .tptfhdlyfsrnakvt c lvssmktienfdiswerekagnlefvtedpvlhdngty
Xl2 241 . . . . . . . . . .rnakvt c lvssmktienfdiswerekagnlefvtedpvlhdngtysvasilsvcaedwes

Xl1 286 . . .svasilsvcaedwesgdkfs c tvrsqdlpspvkktifkqnegtpkapdvy
Xl2 301 . . . . . . . . . . gdkfs c tvrsqdlpspvkktifkqnegtpkapdvyllpps

Hc4
Xl1 336 . . . .llppsaqeliqqemvtlt c fvt gf npkeifiqwmqggvsisedkfintvpmksdg
Xl2 341 . . . . . . aqeliqqemvtlt c fvt gf npkeifiqwmqggvsisedkfintvpmksdg

Xl1 391 .eqtyfiysklaipaakwnqgdvft c vvghealplyitqqsidkssgksslvnvnlvms
Xl2 391 .eqtyfiysklaipaakwnqgdvft c vvghealplyitqqsidkssgksslvnvnlvmsxtdtcy

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Trout Ig heavy chain constant
.1 nsltdfvqypavqtggsymgvsqlrvkradwdskkfe c avehsagskkvpvkkqpeylqq

61 . . . . . . . .pslyvmtpskeemsenktasfa c fan df sprthtikwmrmekgteqevvsdfksscesek
121 . . . . ksettlysttsylrvnesewkseevtft c vfenkagnvrrtvgytssdgpvhghsvviti

181 . . . . . . . . . .iepsledmlmnkkaqlv c dvnelvpgflsvkwendngktltsrkg
226 . . . . . . . vtdkiaildityedwsngtvfy c avdhmenlgdlvkkaykretggvpqrp

276 . . . . . . . . .svfllapaeqtsdntvtlt c yvk df ypkdvlvawlvddepvertsssalyqfntt
331 . . . sqiqsgrtysvysqltfsndlwkneevvys c vvyhesmikstniimrtidrtsnqpnlvnlslnvpqrcmaq

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Hampster IgG heavy chain

Hv
. 1 . . . mvlglhwvffvallkgvhcevqlvesggglvkpagslkls c las gf afsdyfmswfrqapgkglewvagi
.71 dtksydyatyysgsvkgrftisrddsqsmvylqmnnlrtedtatyy c treigywgqgtmvavssatttap

Hc1
141 . . . . . . . . . . . . svyplapacdsttsttdtvtlg c lvk gy fpepvtvswnsg
181 . . . . .altsgvhtfpsvlhsglyslsssvtvpsstwpkqpit c nvahpasstkvdkkieprtdtd

Hc2
241 . .tcpnppdpcptcptpdllggpsvfifppkpkdvlmisltpkit c vvvdvseeepdvqfnw
301 . .yvnnvedktaqtetrqrqynstyrvvsvlpikhqdwmsgkvfk c kvnnnalpspiektis

Hc4
361 . . . . . . . . .kprgqvrvpqiytfpppieqtvkkdvsvt c lvt gf lpqdihvewesngqpqpeqnykntq
421 . . . . . . . . .pvldsdgsyflysklnvpksrwdqgdsft c svihealhnhhmtktisrslgn