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If you develop a potent drug that has a good safety profile than naturally you gotta sell it, right? Well, that is not quite right at all. free steroid information Steroid cream. In fact, if you talk to pharmaceutical researchers they will tell you that only a very minor percentage of drugs that show great promise in the lab and/or clinical setting ever make it to market. The reasons for this can be many fold - a crowded market place, patent protection issues, prohibitively high cost of production, or lack of categorical sales can be a few. With the cost of getting a drug approved by the FDA for sale in the millions of dollars, as well as the high cost of drug marketing, you can see that some serious picking and choosing has to go on . free steroid information Paper steroids. The result is many very potent and promising drugs - anabolic steroids in this instance - falling through the cracks and never seeing the pharmacy shelves. Research and Development of anabolic steroidsFor you to fully appreciate the things I am going to discuss in this article you have to have a background on how anabolic steroids are screened for activity. As you know, anabolic steroids are derivatives of testosterone which share two types of activity - muscle building (deemed anabolic) and non muscle male sex hormone related activity (deemed androgenic). free steroid information Men with muscles. The goal of researchers in the golden age of anabolic steroid research (1935-1965) was to synthesize a compound which retained a high degree of anabolic activity coupled with a vastly diminished androgenic activity. This property was quantified using what is known as the Anabolic / Androgenic ratio (A/A ratio). The goal was not so much to produce a compound that was strongly anabolic, but rather the goal was to produce a compound with the highest possible A/A ratio. You must understand that the market for anabolic steroids was not bodybuilders / athletes but geriatric patients, patients recovering from surgery or injury, or those suffering from weakness or catabolism secondary to some other disease. These can include men and women, and even children. It was therefore paramount to avoid any virilizing effects when providing such people anabolic treatment, and so an anabolic agent with a very low A/A ratio was needed. To determine the A/A ratio, scientists utilized a test called the Rat Levator Ani Assay. In this test, scientists use two groups of castrated rats. The rats are castrated to remove any interfering influence from fluctuating natural androgen levels. The first group of rats are a control group that receives a placebo, while the second group receives the steroid (either by injection or orally). After a period of time (several days to weeks) the rats are sacrificed. Researchers then isolate three organs from each of the rats - the seminal vesicles, ventral prostate, and levator ani muscle. These organs are all weighed and a comparison of the active group to the placebo groups is made. The differences in weights for the seminal vesicles and ventral prostate represent androgenic activity, while the difference in the weight of the levator ani muscles in the control and active group represent anabolic activity. To give a landmark against which to gauge the relative activities of each steroid in this assay, a standard is used in some of the rats in the active group. This standard is usually testosterone, testosterone propionate, or 17alpha-methyltestosterone (MT) and the results obtained from the rats given this standard are designated an arbitrary number of 1 for anabolic activity and 1 for androgenic activity.
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