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Published Online: 6 Dec 1998
Copyright © 1997 Wiley-Liss, Inc.
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Acute exposure to a 60 Hz
magnetic field increases DNA strand breaks in rat brain
cells
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Henry Lai *,
Narendra P. Singh |
Bioelectromagnetics Research Laboratory, Center for
Bioengineering, University of Washington,
Seattle
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*Correspondence to Henry
Lai, Center for Bioengineering, Box 337962, University of
Washington, Seattle, WA 98195
Funded by: National Institute of Environmental Health
Sciences; Grant Number: ES-06290
60 Hz magnetic fields • DNA single-strand and
double-strand breaks • brain cells • microgel
electrophoresis |
Acute (2 h) exposure of rats to a 60 Hz magnetic
field (flux densities 0.1, 0.25, and 0.5 mT) caused a
dose-dependent increase in DNA strand breaks in brain
cells of the animals (assayed by a microgel
electrophoresis method at 4 h postexposure). An increase
in single-strand DNA breaks was observed after exposure
to magnetic fields of 0.1, 0.25, and 0.5 mT, whereas an
increase in double-strand DNA breaks was observed at
0.25 and 0.5 mT. Because DNA strand breaks may affect
cellular functions, lead to carcinogenesis and cell
death, and be related to onset of neurodegenerative
diseases, our data may have important implications for
the possible health effects of exposure to 60 Hz
magnetic fields. Bioelectromagnetics 18:156-165, 1997. ©
1997 Wiley-Liss, Inc. |
Received: 10 January 1996; Revised: 1 July 1996
10.1002/(SICI)1521-186X(1997)18:2<156::AID-BEM8>3.0.CO;2-1 About DOI |
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