8219 Messenger Ct. 27357

Phone 336-510-7959 (Home) / 240-643-1155 (Cell)

e-mail : [email protected]

 

JAYAN NARAYANAN

                                                                                                    Citizenship: India

EDUCATION                                                                                                         Resident: USA

 


2007-Present                                         PharmaCore, Inc.                              High Point, NC, USA

Research Scientist

 

2002 - 2006                             NIDDK/National Institutes of Health             Bethesda, MD, USA

Postdoctoral Fellow

 

2001 - 2002                                         Bar Ilan University                                 Ramat Gan, Israel

Postdoctoral Fellow        

 

April 2001                                               Cochin University of                                  Cochin, India

Ph. D.                                                    Science & Technology

ADVISOR: Dr. Vijay Nair       

¨ Dissertation: “Novel Reactions of Indium Reagents with 1, 2-Diones and Diels-Alder Cycloadditions of Hetero Cyclic o-Quinone Methides”

 

Jul. 1998-Apr. 2001                        CSIR- Regional Research Lab                     Trivandrum, India

Senior Research Fellow

 

Jul. 1996-Jun. 1998                         CSIR- Regional Research Lab                     Trivandrum, India

Junior Research Fellow

 

Jul. 1993-Dec. 1995                           Mahatma Gandhi University                        Kottayam, India

M. Sc.                                

 

Apr. 1990-Apr. 1993                         Mahatma Gandhi University                         Kottayam, India

B. Sc. 

 

TEchnical skills 

 

¨      Experienced in synthesis of a variety of organic compounds especially in the area of hetero Diels-Alder reactions, Organometallic reactions, fluorine substituted bio indoles and imidazoles including amino acid and amino alcohol derivatives and various heterocyclic building blocks such as diazoles, oxazoles, thiazoles, oxazolidinones, thiazolidinones, hydantoins etc.

¨      Experienced in isolation and purification techniques including Flash Column Chromatography, Recrystallisation, Distillation etc.

¨      Experience in using Radleys Greenhouse Parallel Synthesizer (12 and 24 reaction stations)Chemistry, Genevac EZ-2 and instrument H-Cube (automated hydrogenation apparatus from Thales).

¨      Experience in designing and synthesizing organic compounds and the ability to perform multistep synthesis on a milligram, gram to kilogram scale. Worked in an environment of pharmacologists, biochemists, biologists and molecular modelers and interacted with them while designing novel drug like compounds.

¨      Experience in supervising routine lab maintenance tasks such as ordering supplies and periodic maintenance of lab equipments. Experience in maintaining good lab records, computer databases and presenting scientific data and concepts at meetings. Experience in supervising and training associates, assistants and students.

¨      Routinely used modern laboratory techniques and analytical methods (HPLC [Agilent 1100 Series-Method Development and purification checking], GC-MS and LC-MS). Extensive experience in the use of NMR (400MHz) [Brucker & Varian], FTIR (Jasco and Biorad), UV (Beckman DU800) and some experience in computational methods (Titan).

¨      Trained to use Biotage Microwave Apparatus (Initiator eight and sixty) and Automatic Flash Column Chromatography equipments like Biotage SP4 EXP and Argonaut Flash Master II.

¨      Expertise in softwares like Chemdraw, SciFinder, Database formats SDF, Mestrec (NMR software), Endnote, Adobe Acrobat and Photoshop, MS office applications etc.

¨      Good knowledge in computer languages like JavaScript, VB Script, HTML, DHTML, PERL, Web Designing etc.

                                                 

Awards & Memberships

 


µ     Dr. A. M. Chacko Endowment Prize for the Best Performance in M. Sc. 1995

µ     Qualified Graduate Aptitude Test in Engineering (chemical) [GATE-95] 1995 with a percentile score: 98.4. (Received 33rd rank in all India level).

µ     Awarded Junior Research Fellowship by Council of Scientific and Industrial Research, India (1996-98).

µ     Awarded Senior Research Fellowship by Council of Scientific and Industrial Research, India (1998-2001).

µ     Awarded Visiting Fellowship by National Institutes of Health (NIH), Bethesda, MD, USA (2002-2005).

µ     Full member of American Chemical Society (Organic).

 

EXTRACURRICULAR ACTIVITIES

 


Ø      Participated in Drama competition in school level

Ø      Participated in National Cadet Core (NCC) during 1988-90

Ø      Secretary of Chemistry Association (1991-92) of Union Christian College, Alwaye, India

Ø      Elected as Representative of M.S. students in College Union during 1993-94

Ø      Winner of Intercollegiate Quiz competition in chemistry ( M. G. University Level) in 1994

Ø      2nd place in Interuniversity Quiz competition in Chemistry (held at Cochin University of Science and Technology) in 1994

Ø      Active Volley Ball and Tennis player

Ø      Organized trips to  various industries and places in India during M.S. and Ph.D. period

 

REFERENCES

 

       References are available on request

 

Publications and Presentations

 

Peer Reviewed Publications

1.                  C. P. Corpe, J. H. Lee, O. Kwon, P. Eck, Jayan Narayanan, K. L. Kirk, M. Levine.  6-bromo-6-deoxy-L-ascorbic acid: an ascorbate analog specific for Na+ dependent vitamin C transporter but not glucose transporter pathways. J. Biol. Chem. 2005, 280, 5211-5220.

2.                  B. Dolensky, G. Nam, W. P. Deng, Jayan Narayanan, J. Fan, K. L. Kirk. Syntheses of side-chain fluorinated biologically important imidazoles and indoles. J. Fluor. Chem. 2004, 125, 501–508.

3.                  V. Nair, Sindu Ros, Jayan, C. N., Bindu S. Pillai. Indium- and gallium-mediated carbon–carbon bond-forming reactions in organic synthesis. Tetrahedron, 2004, 60, 1959–1982.

4.                  Nair, V., Ros, S., Jayan, C. N., Viji, S. Indium mediated allylation and propargylation of isatins: a facile synthesis of 3-substituted 3-hydroxy oxindoles. Synthesis, 2003, 2542-2546.

5.                  B. Dolensky, Jayan Narayanan and K. L. Kirk. Preparation of b-fluoro- and b,b-difluoro- histidinols. J. Fluor. Chem. 2003 123, 95-99.

6.                  Jayan Narayanan, Y. Hayakawa, J. Fan, K. L. Kirk. Convenient Syntheses of Biogenic Aldehydes, 3,4-Dihydroxyphenylacetaldehyde and 3,4-Dihydroxyphenylglycolaldehyde. Bioorganic Chem. 2003, 31, 191-197.

7.                  Nair, V.; Ros, S.; Jayan, C. N.  Rath, N. P. Indium/indium trichloride mediated pinacol cross-coupling reaction of aldehydes and chalcones in aqueous media: a facile stereoselective synthesis of substituted but-3-ene-1,2-diols. Tet. Lett., 2002, 43, 8967-8969.

8.                  V. Nair, C. N. Jayan, P. M. Treesa, J. S. Mathen, L. Varma. A Facile generation of quinolone quinone methide and its [4+2] cycloaddition to pentafulvenes: synthesis of novel pyranoquinolinone derivatives. Ind. J. Chem. B, 2001, 40B, 1108-1113.

9.                  V. Nair, P. M. Treesa, C. N. Jayan, N. P. Rath, M. Vairamani and S. Prabhakar. Diels-Alder trapping of 3-methylenequinolin-2,4-Dione: A facile synthesis of pyranoquinolinones and spiroquinoline diones. Tetrahdron, 2001, 57(36), 7711-7717.

10.              Nair, V.; Ros, S.; Jayan, C. N.  Gallium Mediated Barbier Reactions of 1,2-Diones: A Facile Synthesis of alpha-Hydroxy Ketones.  J. Chem. Res., 2001, 551-553.

11.              Nair, V.; Jayan, C. N.; Ros, S.  Novel Reactions of Indium Reagents with 1,2-Diones: A Facile Synthesis of alpha-Hydroxy Ketones. Tetrahedron, 2001, 57(46), 9453-9459.

12.              Nair, V.; Jayan, C. N.; Radhakrishnan, K. V.; Anilkumar, G.; Rath, N. P.  [4+2] Cycloaddition reactions of coumarin quinone methide with pentafulvenes: facile synthesis of novel polycyclic pyran derivatives. Tetrahedron 2001, 57 (27), 5807-5813.

13.              V. Nair and Jayan, C. N. "Indium mediated Barbier reactions of 1,2-diones: a facile synthesis of a-hydroxy ketones", Tetrahedron Lett., 2000, 41, 1091-1094.

14.              V. Nair, G. Anilkumar, Jayan, C. N. and N. P. Rath. "A Novel Photochemical Rearrangement of 1,3-Diaryl-1,2-dihydropentalenes to the 1,5-Isomers and their Domino Diels-Alder reactions", Tetrahedron Lett., 1998, 39, 2437-2440.

                        

Posters at Symposia and Talk

1.                  Kirk, Kenneth L.; Cramer, John; Hajduch, Jan; Hayakawa, Yoshio; Heredia-Moya, Jorge; Narayanan, Jayan; Ye, Song. “New approaches to fluorinated heterocyclic compounds.”,     Laboratory of Bioorganic Chemistry, NIDDK,  NIH, Department of Health and Human Services,  Bethesda, MD, USA. Abstracts of Papers, 230th ACS National Meeting, Washington, DC, United States, Aug.28-Sept.1, 2005, (2005), FLUO-011.  Publisher: American Chemical Society, Washington, D. C CODEN: 69HFCL Conference; Meeting Abstract. AN 2005:738487.  

2.                  Jayan Narayanan. “Convenient Synthesis of Side Chain Fluorinated Bio Indole and Imidazole Derivatives”. Invited talk at H. Lee Moffitt Cancer Center & Research Institute, Tampa, Florida. June 8th, 2005.

3.                  Jayan Narayanan. “Convenient Synthesis of Fluorinated Bio Indole and Imidazole Derivatives”. Invited talk at Rensselaer Polytechnic Institute (RPI), Troy, New York. April 22nd, 2005.

4.                  Kirk, Kenneth L.; Dolensky, Bohumil; Narayanan, Jayan; Nam, Ghilsoo; Deng, Wei-Ping; Fan, Junfa. “Building blocks for the preparation of fluorinated bioimidazoles and bioindoles.” Laboratory of Bioorganic Chemistry, NIDDK, NIH, Department of Health and Human Services, Bethesda, MD, USA. Abstracts of Papers, 226th ACS National Meeting, New York, NY, United States, September 7-11, 2003 (2003), FLUO-007. Publisher: American Chemical Society, Washington, D. C CODEN: 69EKY9 Conference; AN 2003:631712.   

5.                  Jayan Narayanan, Bohumil Dolensky and Kenneth L. Kirk.  “Convenient Syntheses of Side-Chain Fluorinated Bioimidazoles”, 38th National Organic Symposium, Indiana University, Bloomington, Indiana, USA.  June 8-12, 2003.

6.                  Jayan, C. N. and V. Nair. "Indium Mediated Barbier Reactions of 1,2-Diones: A Facile Synthesis of a-Hydroxy Ketones", Second National Symposium in Chemistry held at IICT, Hyderabad, India. January 27-29, 2000, Abstract, p 121.

7.                  A. G. Nair, Jayan C. N. and V. Nair. "Photoinduced Rearrangement of Diaryl-1,2-dihydropentalenes to 1,5-Dihydropentalenes and Domino Diels-Alder reactions with Dienophiles", National Symposium On Emerging Trends in Organic Chemistry held at Trivandrum, India. November 18-19, 1996, Abstract, P 1907/06/1999.

   
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