Fig 7   Uninfected cell treated with reverse transcriptase inhibitors plus protease inhibitors. When there is viral resistance to the reverse transcriptase inhibitors, there will be a "leak" through the block, a pro virus will form and the cell will become infected. In this situation because of phosphorylation by CK2 there is increased risk of viral resistance to the reverse transcriptase inhibitors

This diagram can be compared to the diagram for uninfected cells treated by reverse transcriptase inhibitors plus CK2 inhibitor. .