|
|
|
|
Dr. Naveen K. Khare
Designation:
Reader
Branch: Organic Chemistry
Specialization: Carbohydrates
Natural Products
Date of Birth: August 17, 1958
Residence: B 2159, Indiranagar, Lucknow
Phone: 0522-235-4258
email: [email protected]
Degrees
Ph.D.,1985, Lucknow University, Lucknow, INDIA
M.Sc.,1979, Lucknow University, Lucknow, INDIA
B.Sc.,1977, Lucknow University, Lucknow, INDIA
Positions Held
Teaching post graduate & undergraduate students at department of chemistry, university of Lucknow, Lucknow- 226007, India since may 1988 – till date.
On sabbatical for three years as visiting scientist at southern research institute, u.s.a. since January 1999 to January. 2002.
Visiting Research Associate with Prof. G. O. Aspinall, department of Chemistry, York University, Toronto, Canada since July 1991 to November 1992.
Post doctoral fellow with Prof. G. O. Aspinall at department of chemistry, York University, Toronto, Canada since November 1986 to may 1988.
Post Doctoral Research Associate at Medicinal Chemistry, Central Drug Research Institute, Lucknow, India since October 1984 to October 1986.
Research Interests
Synthetic carbohydrate chemistry. In USA, was working on a NIH. sponsored project involving design & synthesis of variety of novel target compounds as inhibitors of key enzymes in the mycobacterial cell wall synthesis for the development of potential antitubercular agents. This work involves stereo and regioselective synthesis of di- and oligosaccharide heteroanalogs as potential inhibitors of mycobacterial glycosyl transferases in which the interglycosidic oxygen and/or ring oxygen has been replaced by sulfur.
Have also worked on the synthesis of complex carbohydrates involving deoxy hexoses, 4,6-pyruvylated hexoses and unusual heptoses of defined configuration found in mycobacteria (especially mais complex ) & campylobacter etc. Each presenting challanges for the development of strategy for stereo and regioselective synthesis of target compounds with careful manipulation of functionality with varying degree of lability. The main objective was to prepare neoglcoconjugates in which the outer sugar residues of the natural antigens are attached to carrier proteins. The neoglycoconjugates were then characterized for their ability to interact with antibodies to individual strains of mycobacteria & thus give information on the specificities of the antibodies. The knowledge thus obtained, contribute significantly to our understanding of the immunochemistry of these organisms and may also have practical consequences in the serodiagnosis of bacterial infection. This work is evident by the list of publications.
Secondly, was also engaged in the development of synthetic methods for carbocyclic nucleosides as hypoxanthine guanine phospho ribosyl transferase (hgprt) inhibitors present in pathogenic organisms that cause opportunistic infections in hiv/aids. These compounds are not only difficult to handle but also involve a tedious route in multistep synthesis. Also, pursued the synthesis of complex heterocyclic target compounds derived from natural products as selective ligands for the opioids receptors of the central nervous system. This research is directed toward the discovery & development of new ligands possessing potent analgesic activity devoid of the side effects that are associated with currently available drugs for the treatment of chronic pain.
Conferences/Workshops
XX Carbohydrate Conference (carbo xx) as Organising Secretary, Chemistry Department, Lucknow University, Lucknow, India 2005.
222nd American Chemical Society meeting, Chicago, Il, usa, 2001
219th American Chemical Society meeting, San Francisco, CA, usa, 2000.
Carbohydrate conferences at Indian Institute of Chemical Biology, Calcutta, India 2003 & f.r.i. Dehradun, India 1998 and 2004.
xii Carbohydrate Conference as Organising Secretary, Chemistry Department, Lucknow University, Lucknow, India 1997.
International symposium: global challenges in drug development at central drug research institute, Lucknow, India 1994 & got cash award for best paper on “stereoselective synthesis of di & trisaccharide fragment related to the o-polysaccharide of acetobacter xylinum as artificial antigens”.
International carbohydrate symposium at Paris, France 1992.
North American Chemical society meeting at university of Toronto, Toronto, Canada 1988.
Gordon Research Conference on carbohydrate, Tilton, new Hampshire, usa 1987.
Books/Monographs
Written one chapter of the book “ progress in the chemistry of natural products” vol.69, 61, 1997. Founded by l. Zechmeister, edited by w. Hertz, g.w. kirby, r.e. moore, w. Steglich & ch. Taman. Published by springer verlag, new york.
written chapters in-
Syntheses Of Suitably Protected Glycosyl Acceptors And Donors Of D-Glucose And D-Mannose Leading To Mono And Diglycosyl Neoglycoproteins. IX Carbohydrate Conference 1993 at cdri, Lucknow and published as a chapter in a book “Trends In Carbohydrate Chemistry”, ed. P.L.Soni, p. 5, 1995, Surya Publication, Dehradun.
Syntheses Of Oligosaccharides Involving a-L-Rhamnopyranoside Derivatives For Conversion Into Neoglycoproteins. IX Carbohydrate Conference, 1993 at cdri, Lucknow and published as a chapter in a book “Trends In Carbohydrate Chemistry” ed. P.lL Soni, p-17, 1995, Surya Publication, Dehradun.
Structure of royleose. XI Carbohydrate Conference, iicb, Calcutta, November 1996 and detailed paper accepted in a book “trends in carbohydrate chemistry” 3, 65-67, (1996). Ed. P.L. Soni, Surya Publication.
Stereoselective synthesis of disaccharides corresponding to antigenic factor 9 of candida guilliermondii suitable for chain extension, xii Carbohydrate Conference, chemistry department, lucknow university, Lucknow, November 1997, also published in a book Trends In Carbohydrate Chemistry, 4, 51, 1999. Ed. P.L. Soni, Surya Publication, Dehradun.
Synthesis of 4-thioarabinofuranose disaccharides as mimics in inhibiting the mycobacterial glycosyltransferases. Invited lecture in xviii carbohydrate conference, i.a.c.s., Kolkata 2003
Also helped in writing monograph “compendium of Indian med. Plants” Vol.1, 1990 of publication & information directorate, New Delhi
Selected Publications
Three Pregnane Glycosides from pergularia pallida, Natural Product Communication, 2006, (Accepted for Publication)
Identification Of Opioid Ligands Possessing Mixed Micro Agonist/Delta Antagonist Activity Among Pyridomorphinans Derived From Naloxone, Oxymorphone, And Hydromorphone [Correction Of Hydropmorphone]. J. Med. Chem. 47(6), 1400-12, 2004. (Erratum In: J. Med. Chem. 47(10), 2716, 2004).
Novel Ligands For The Opioid Receptors: Synthesis And Structure-Activity Relationships Among 5'-Aryl And 5'-Heteroaryl 17-Cyclopropylmethyl-4,5a-Poxypyrido [2',3':6,7] Morphinans. Bioorganic And Medicinal Chemistry. 11, 4143-4154, 2003.
Synthesis Opioid Receptor Binding, and Functional Activity of 5* -Substituted 17 cyclopropyl methylpyrido[2*, 3* : 6:7]morphinans, Bioorganic And Medicinal Chemistry Letters. 13, 529-532, 2003.
Isolation And Structural Studies Of Pregnanes & Their Glycosides From Marsdenia Roylei. Phytochemistry, 64, 1327-1333, 2003.
Enantioselective Route To A Key Intermediate In The Synthesis Of Carbocylic Phosphoribosyltransferase Transition State Analogues. Tetrahedron, 57, 9899, 2001.
Synthesis Of Disaccharides Related To The Mycobacterial Arabino-Galactan. Carbohydrate Letters, 2001, 4(2), 117-122.
Stereoselective Synthesis Of Some 1,2-Trans-Linked Oligomers As Allyl Glcoside Using Trichloroacetimidate Donors. Indian J. Chemistry 39b, 346, 2000.
Memberships
Presently Joint Secretary of Association of Carbohydrate Chemists & Technologists of India (ACTTI).
Research Guidance / Professional Consultancy
Currently running three research projects funded by Department of Science & Technology, New Delhi, C.S.I.R., New Delhi and Council of Science & Technology, U.P.
Three Ph.D. thesis of Drs. Ritu Mahajan, Sapna Dixit & Sangeeta Srivastava were awarded by this university under my co-supervision.
Two Ph.D. students, Dr. Alok Kumar & Dr. Vijay Shanker Gupta have been awarded Ph.D. degree under my supervision by L.U.
Presently, three research scholars are working with me for their Ph.D. degrees
Reviewed manuscripts for publications in Phytochemistry, Journal of Natural Products, Natural Product Communications and Ind. J. Chemistry as and when required. Also reviewed many Ph.D. theses of various Universities.
Administrative assignments
In Charge, F.T.I.R. lab. (Installation and operation) under D.S.T.- F.I.S.T. Programme.
Astt. O.S.D., UG Dispatch & Evaluation, L.U. exams 1988–1989.
Member of checking squad, L.U. exams 1989–1990 & 1990–1991.
Astt. Provost, Birbal Sahni Hall, L.U. from 1989-1991.
President Gymnastic Club , L.U.A.A. from 1990-1991.
Member of Board of Studies, Chemistry Department, L.U. 1993-1995 and 2002-2005.
Astt. O.S.D., PG evaluation and result, L.U. Exams 1995-1996.
Science Representative of Lucknow University Teachers Association, 1995-1997.
Joint Secretary of Lucknow University Teachers Association (L.U.T.A.), 1997-1999.
Superintendent, P.G. Results Cell (Regular & Back Paper), L.U. Examination 2003-2005
President Badminton Club, L.U.A.A. from 2006-till date.
Previous