Bipolar disorder
��DSM IV Criteria for Manic Episode A) A distinct period of abnormally and persistently elevated, expansive or irritable mood, lasting at least 1 week (or any duration if hospitalization is necessary)

B) During the period of mood disturbance, three (or more) of the following symptoms have persisted (four if the mood is only irritable) and have been present to a significant degree:

1) inflated self-esteem or grandiosity
2) decreased need for sleep (e.g., feels rested after only 3 hours of sleep)
3) more talkative than usual or pressure to keep talking
4) flight of ideas or subjective experience that thoughts are racing
5) distractibility (i.e., attention too easily drawn to unimportant or irrelevant external stimuli)
6) increase in goal-directed activity (at work, at school, or sexually) or psychomotor agitation
7) excessive involvement in pleasurable activities that have a high potential for painful consequences (e.g., engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments)

C. The symptoms do not meet criteria for a Mixed Episode.

D. The mood disturbance is sufficiently severe to cause marked impairment in occupational functioning or in usual social activities or relationships with others, or to necessitate hospitalization to prevent harm to self or others, or there are psychotic features. 

E. The symptoms are not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication, or other treatment) or a general medical condition (e.g., hyperthyroidism). 

Note: Manic-like episodes that are clearly caused by somatic antidepressant treatment (e.g., medication, electroconvulsive therapy, light therapy) should not count toward a diagnosis of Bipolar I Disorder.

�@

��Criteria for a Hypomania A. A distinct period of abnormally and persistently elevated, expansive, or irritable mood, lasting at least four days, that is clearly different from the usual nondepressed mood.

B. During the period of mood disturbance, three (or more) of the following symptoms have persisted (four if the mood is only irritable) and have been present to a significant degree:

1) inflated self-esteem or grandiosity
2) decreased need for sleep (e.g., feels rested after only 3 hours of sleep)
3) more talkative than usual or pressure to keep talking
4) flight of ideas or subjective experience that thoughts are racing
5) distractibility (i.e., attention too easily drawn to unimportant or irrelevant external stimuli)
6) increase in goal-directed activity (at work, at school, or sexually) or psychomotor agitation
7) excessive involvement in pleasurable activities that have a high potential for painful consequences (e.g., engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments)


C. The episode is associated with an unequivocal change in functioning that is uncharacteristic of the person when not symptomatic.

D. The disturbance in mood and the change in functioning are observable by others.�]���ئ@�@�����N�^

E. The episode is not severe enough to cause marked impairment in social or occupational functioning, or to necessitate hospitalization, and there are no psychotic features.�]�å��Y���y��¾���ê�I�I�^
�@

Mania/Hypomania 1.Hopitalization
2.Psychosis
3.Severe role dysfunction

��ļ�g�Pļ�g�b�E�_�ǫh�W�j�P�ۦP
��̳̤j�����P�b��
1.��̭n�C�ѥH�W���g���A�e�̥u�n�|�ѥH�W�C
2.��̳y��¾��ͬ������j�v�T�A�ӫe�̤Ϧӥi�������{��n�C

���G�̦P�Q�����e�f����¦�b��G

1.�L�̪�"high"�O"abnormally and persistently"�A���y�ܻ��A�O�S�������]�ӳy�������ܡC�@��H�b�D�{�ߨƮɡA���M�]�i�H�g���Ҵy�z���ּ֯g���]�H�{�ߨƺ믫�u�n�v�^�A���L�̦������]�]���ߨơ^�A�P�ɱj�׷|�v����z�B���򪺮ɶ��B�W�v�����סA�O�X�G�u�`�A�v(normal)���C���G�̨S�������]�B�j�צb�g���@�q�ɶ��ᤣ����z�A�N�O�u�D�`�A�v(abnormal)���C�o�ŦX�کҿת��u���ѦۥD�v��'madness"�����C
2.�E�_�W���T�u�a�g���A�ثe�S���i�̿઺�Ͳz���СC

�G�̻ݭn�v������¦�b��G

1.�U�{ļ�g���u��G�v�G�]�A�۱��]�S�O�O�{���^�B�s���Ī����}�B�B�äu�@���D�����C
2.��ļ�g����ݭn�v���H�]���X�G�S����H����@�������b�����N����ļ�A�q�`�|���ܦ�ļ�g�A�Ϊ̬O�{�g�C�ھڬ�s(Arch Gen Psychiatry 2003; 60: 261�V269)�A �o�ءu�ĤG��ļ�{�g�v�����b�@�~�̦�53.9%���ɶ����g���A50.3%���ɶ��O�{���A1.3%���ɶ��~�O��ļ���A�t�~��2.3%�h�O�ֳt�����g���C�]���A���O�����v�����C�ܩ�v�����Ī��A�H�Y�Q������í�w�����D�A�b�{���A�h�u�[�v�W���{���C�Y�u�u�v�ϥΧ��{���A�q�`�|�޵oļ�g�A�G�G�̦X�ΡC

�@

��lithium toxicity (acute)
�@
��The toxic syndrome occurs at levels above 1.4 mmol/l and involves a decreased appetite, diarrhoea, vomiting, ataxia, nystagmus, dysarthria, confusion, and epileptic seizures. Toxicity may lead to coma with hypereflexia and increased muscle tone. A few patients may sustain irreversible neurological damage.

��Lab: ��Leukocytosis, Hyperglycemia, Albuminemia, Glycosuria, nephrogenic DI, AV block, prolonged QT, VT

��Fluid and electrolyte balance should be corrected and a forced diuresis or dialysis should be commenced. Symptomatic and supportive measures are given, for example, for seizures.

��Risks of developing a toxic reaction:
1. impaired renal function
2. dehydration - due to, for example, diarrhoea and vomiting, or increased perspiration when visiting a hot country. If the patient becomes dehydrated lithium treatment should be stopped.
3. Significant lithium toxicity may occur when lithium is allowed to interact with sodium depleting drugs especially thiazides.

�@

Essence Drive��, Disinhibition, Threshold��
�@ �@


Hosted by www.Geocities.ws

1