All comments must in some way offend Lisa only SLIGHTLY, no more, no less.
Just Do It - many comments depend on situational comedy, although common topics to start a harassment are: sleeping on her bed, religious outings that were a waste of a weekend, most recent whining. The key to the game - use your judgement.
Just when it appears that Lisa's not going to talk to you anymore (ever), apologize, then immediately make fun of her again for calling it the "apology phase."