
Dear Friends,

I thought I'd pass along a most interesting report that was published
in the latest Entheogen Review.  The report is certainly lacking some
key information, but from the sound of it the mysterious author could
really be on to something. I will follow up this report with a
transcript of the proper Lloydia paper that was incorrectly referanced
in the E.R. report.  Once the groundwork has been layed out, I'd like
to open up a discussion about the possible conversion techniques and
chemistry questions...

Here is the original report written by the Inner Frontiersman from 
the Vernal Equinox 1997 Entheogen Review in most of it's entirety:

"First Known Human Voyage on DCM -- 2,6-dichloromescaline"

Dekorn writes: On Page 7 of the Spring 96 ER is a piece by the
following author, speculating on how to make 2,6-dichloromescaline. 
This previously uninvestigated compound, a presumed "super entheogen"
was first mentioned in Lloydia, Vol. 40, No.6 in an article entitled
"Cactus alkaloids XXXVI.  Mescaline and related compounds from
Trichocereus peruvianus" (**Dekorn had cited the wrong title here
which I have corrected**)  The article's authors speculated that on
the logic of molecular chemistry alone, 2,6-dichloromescaline should
be "well within the range where psychoactivity would be expected." Not
to be daunted, our intrepid psychonaut took the considerable trouble
to make some and here are his results...

Inner Frontiersman writes:  After spending a small fortune to isolate
the pure mescaline, then convert it to DCM, I gave myself two weeks to
mentally prepare. All the information was theoretical -- it could be a
dud, it could be a psychotic agent, or it could be a super entheogen.
I decided to start the test at 4:30 AM, three hours before sunrise on
April 26, 1996. 

4:30AM          10mg DCM
5:00AM          Nothing 
5:30AM          Nothing 
5:45AM          Nothing         
6:00AM          +1      
6:30AM          +2 1/2  
6:45AM          +3 1/2          

At this point the intensity was rocketing past the equivalence of
2 full window panes = 300 mcg. LSD.  Things dissolved and 
dissasembled.  I could see my consciousness separate into a dozen or 
so points in space.  My eyes, and every other element of 
consciousness were all "thinking" on their own.  I had the ultimate 
terror that I was dissasembling into nothingness, but suddenly, this 
struck my emotional essance as highly comical.  This laughter spread 
through all of my other essences like a pencil links each dot in a 
connect the dot puzzle.  

This was a grand awakening voyage.  At one point I experianced what
could only be called a "mental sex change". I percieved myself as both
physically and mentally female.  After a brief wave of terror, I
realized that, without going into great explanation, there is power in
being female. 

A vision of what I could only reason was that of the Creator's
followed.  Both extreme terror and total peace and happiness filled
me.  I saw a pastel rainbow hue of colors.  In the middle of these
colors a beam of golden light projected outwards towards me.  When it
struck, I felt only the peace and joy of the beam as well as heard a
voice that said many things.  The only phrase I remember was "Do not
be tricked by the evil ones that inhabit other realms, resist them,
and they will flee in terror, they only have the power you give them!"

There was an image of a small frog like creature belching out the
usual phrases to intimidate psychonauts.  I laughed uncontrollably at
this pathetic little evil "thing" until I hurt.  It then vanished. 
The rest of the voyage was filled with nice visuals, great euphoria.

The total elapsed time breaks down as follows:  From plus-1 to plus-1,
about 22 hours.  The plus-2 state lasted about 13 hours, and the
plus-3 portion of the trip was about 9.5 hours.  The only problems
were intermittent power surges through my body, with both feelings of
electricity and some trembling.  This was on a dosage of only 10mg!  I
wouldn't take this amount again-- I was lucky.  A recomended starting
dose would be 3-5mg. Note: all of my DCM notes and formulas were
destroyed in an electrical fire about 2 weeks later!  I had plans for
a psychedelic salve: about 1mg of DCM in DMSO.  The fire stopped this,
at least for now.  Due to the molecular structure of DCM, DMSO should
be an excellent vehicle for delivery.  Hopefully someone with better
scales and equipment will give a good scientific investigation of DCM.

-Inner Frontiersman

To be continued in the next post the series...

Toad

----------------------------


The Inner Frontiersman then goes on to speculate about various
conversion methods without saying exactly how he produced the final
DCM product.  He also makes an error in his interpretation of the
Lloydia paper stating that the DCM was an artifact from trying to
purify mescaline HCL using chloroform as a separating solvent.  The
paper actually stated that 2-chloromescaline was the artifact and they
later created DCM in a separate procedure.


Inner's report continued:       

2,6-dichloromescaline was an artifact from trying to purify mescaline
HCL by using chloroform as the separating solvent.  It seems that the
chloroform has some free radical Cl ions available and by accident,
they bound to the mescaline.  They found this residue, about 3%
conversion during some chemical tests.  The conversion happened over
an 8 hour period.

The first route to 2,6-dichloromescaline would be to take nearly pure
crystals generated by the easy extraction method and dissolve them in
chloroform, about one pint to 300mg.  Then add the catalyst to speed
up the chloroform's formation of free Cl, potassium permanganate,
about 200mg.  Allow this to set for one full day, which will give time
for the conversion. 97%. (This is not the procedure from the Lloydia
paper.  If this is the procedure he followed then there would be 40% 
potassium permanganate in the final product that would need to be 
removed somehow)

The simpler method would be to dissolve 300mg of mescaline in one
liter of chloroform in a sealable glass container and let it sit for a
month, allowing the chloroform to release the Cl as part of its
natural decay.  Once a week you'd open the container to let the
voatile hydrocarbons out: being careful not to inhale them.  Probably
six weeks at 72 degrees would yeild better results.  You want to
ensure that all the solids stayed in solution by regular stirring or
shaking.  If you started with a reletively pure product, you could
allow the chloroform to evaporate off leaving the DCM as residue.

A note on dosage: I checked the calibration of my old triple-balance
scale against two others and discovered and error between 6 and 21 mg
with no consistant pattern!  Which means that my "10mg" dose could
have been anywhere from 6 and 21mg.  This stuff gave all the weird
electric power surges similar to what I have read in Dr. Shulgin's
descriptions of many of the psychedelic amphetamines.  At times I felt
like I was strapped to the front of a runaway locomotive: this is a
very very pushy material!  I don't know anyone who has braved high
dose STP (DOM), but maybe they have some tips to prevent tragedies.
Start with a low dose would be my plea to anyone interested in DCM.
This is not high-dose mushroom madness, or peyotehuasca music of the
spheres!  In other words, although I had a great time, if I had fought
in the least bit, it woud probably have put me through a mental and
spiritual food processor.  The only favor that I ask is that someone
you know and trust who can get the Lloydia recipie for DCM and verify
that it is a psychedelic trip and not poison. 

-Inner Frontiersman

Next up, the transcription of the Lloydia article on the conversion 
process...

Toad

--------------------------------------


Taken from Lloydia Vol. 40 No.6 "Cactus Alkaloids XXXVI. Mescaline 
and Related Compounds from Trichocereous peruvianus" (p585)

Preparation of 2-chloromescaline and 2,6-dichloromescaline hydrochlorides.
Chlorine gas was generated from potassium permanganate and hydrochloric 
acid, and a 5% (w/v) solution was prepared in chloroform.  A total of 
150mg of mescaline hcl was disolved in 100ml of chloroform to which 1ml 
of the chlorine solution was added.  After the mixture was kept at room
temperature for 2 hours the solvent was removed under rotary vacuum
(only 2,6-dichloromescaline was formed if the mixture was kept for longer 
periods of time). The residue was treated in the usual manner to 
crystalize 120mg of hydrochloride (shiny plates, mp 218-22). 
Recrystalization (absolute ethanol-ethyl ether) purified this material,
which was identified as 2,6-dichloromescaline hydrochloride mp 225-227. 
The mother liquor from the crystalization of the 2,6-dichloromescaline 
hydrochloride showed three spots upon analytical tlc in solvent(ethyl 
acetate-methanol-58% amonium hydroxide (17:2:1))at 0.36, 0.55, and 0.77 

The mixture (90mg) from similar mother liquors was subjected to 
preparative tlc (three plates, two developments).  The band at Rf 0.36 
yielded 26mg of recovered mescaline hydrochloride; the band at 0.77 gave
36mg of additional 2,6-dichloromescaline identical to that obtained 
previously.  The band at Rf 0.55 yielded 15mg of 2-chloromescaline 
hydrochloride.

Ok, now that the ground work has been layed out we can procede to the next
post with commentary about the conversion process and questions...

Warm Regards,

Toad

--------------------------------------

I gladly present the following brief synopsis and data-points to
finally bring the 2,6-dichloromescaline saga to completion.

The 2,6-dichloro and the mono-chloro mescaline derivatives were not
active in the 3-10mg range as described in the Entheogen Review article 
by the Inner Frontiersman.  The article was a hoax, and most likely 
based upon the predicted activity of these compounds by structure activity 
relationships.    

Both 2,6-dichloro and the mono-chloro compounds were active in humans
in dosages greater than 75mg.  One experimenter found 150mg of the 
mono-chloro compound to be psychoactive. The experimenter involved was 
not overly impressed with the effects elicited, and said that he was
not interested in exploring things any further.

The 2,6-dibromo and mono-bromo compounds seemed to be more interesting.  
I had the opportunity to taste the mono-bromo, and found 130mg to be a 
fully active amount for me.  It elicited an enjoyable psychoactive 
state that reminded me of 2cb without the stimulating bzzz.  While my 
trials of this material were encouraging, it definitely pales in 
comparison to the ancient mescaline diamond and therefore leaves me 
asking the question "why bother".  

The iodo derivative was also prepared and tasted, and the effects from
the first effective trial seem to encourage further exploration.

Toad