-------------------------------------------------------------------------------
                            Syntheses of Carfentanil
-------------------------------------------------------------------------------
                         ___
                        /   \
                       <  O  >--CH2      ___   CO2CH3
                        \___/    \      /   \ /
                                  CH2--N     X
                                        \___/ \
                                               N-CO-C2H5
                                           ___/
                                          /   \
                                         <  O  >
                                          \___/

        "For instance, carfentanil is approximately 4000 times as potent
        as heroin and has an extremely favorable therapeutic index (Janssen
        1985). Hence, an easy week's work for two chemists could provide
        1 (one) kilogram of carfentanil which would be equivalent to 40
        metric tons of pure heroin"

        Donald A. Cooper (DEA) in "FUTURE SYNTHETIC DRUGS OF ABUSE"

        Very, very good idea, Mr. Cooper. Thanks, DEA!

-------------------------------------------------------------------------------

Carfentanil synthesis, taken from US Pat. 4,179,569

Example IX

To a mixture of 102 parts of phenethyl-piperidone-4, 47 parts of aniline and 370
parts of acetic acid is added dropwise a soln of 36 parts of KCN in 100 parts of
water, at a temperature between 35-45 C (exotermic reaction). After the addition
complete, the cooling-bath is removed and the whole is stirred for 20 hrs at
room temperature. The reaction mixture is poured into 650 parts of ammonium
hydroxide and 500 parts of crushed ice are added. The mixture is extracted with
chloroform. The organic extract was dried over potassium carbonate, filtered and
evaporated. The resudie (solid) was triturated in diisopropylether (DIPE). After
keeping at RT, 4-anilino-4-cyano-1-(2-phenylethyl)-piperidine (I) is obtained;
mp 120-121 C.

To 4500 parts of conc. H2SO4 are added portionwise 710 parts of (I), while
keeping the T below 25 C. Upon completion, stirring is continued overnight at
RT. The reaction mixture is poured onto a mixture of 10.000 parts of crushed ice
and 3600 parts of ammonium hydroxide. The product was extracted with chloroform,
extract dried, filtered and evaporated. The residue is stirred in 140 parts of
DIPE, cooled, the product filtered off and dried, yielding 4-(phenylamino)-
1-(2-phenylethyl)-4-piperidinecarboxamide (II), mp 182.5 C

A mixture of 105 parts of (II), 53.7 parts of KOH and 275 parts of ethylene
glycol is stirred and refluxed for 20 hrs. After cooling the RM is poured onto
1000 parts of water and the whole is filtered. The filtrate is strongly
acidified with HCl soln till the formed precipitate enters solution. Then the
soln is strongly alkalized with a conc NaOH soln (exotermic rxn) and filtered
hot.The sodium salt is allowed to crystallize from the filtrate. It is filtered
off and recryst from water, yielding 4-(phenylamino)-1-(2-phenylethyl)-
4-piperidinecarboxylic acid, sodium salt (III), mp > 300 C (dec)

A solution of 62.3 parts of (III), in 340 parts of HMPA (hexamethylphosphoric
triamide, can be subst. to DMSO) is stirred and heated to 100 C. After cooling
to 10 C, there are added dropwise 28.4 parts of iodomethane, (slightly exotermic
reaction). Upon completion, stirring is continued for 24 hrs at RT. Then the
reaction mixture is poured onto water (800 parts) and product is extacted with
tolyene. The extract is washed with water, dried, filtered and evaporated. The
oily residue solidifies on trituration in DIPA, yielding methyl 4-(phenylamino)-
1-(2-phenethyl)-4-piperidinecarboxylate (IV), mp 94.9 C.

A mixture of 33.8 parts of (IV), and 100 parts of propionic anhydride is stirred
and refluxed for 6.5 hrs. The reaction mixture is allowed to cool overnight to
RT while stirring and poured onto ice-water. The product is extracted with
toluene, extract washed with water, dried, filtered and evaporated. The residue
converted onto the citrate salt in IPA and diethyl ether. The oily salt is
triturated in a mixture of IPA and ether, the solid product filtered off and
recryst. twice first from IPA, then from acetone, dried in vacuo at 100 C,
yelding carfentanil citrate, mp 151-154 C. For oxalate salt ED50 = 0.0006 mg/kg
i/v, this mean that for 100-kg body you need only 0.06 mg.

FYI, for 3-methylfentanyl (ED50=0.00058 mg/kg i.v.) look up is synthesis in
J. Med. Chem. vol 17, No. 10, p. 1047 (1974).

-------------------------------------------------------------------------------

Carfentanil synthesis, taken from US Pat. 5,106,983

A solution of 60.5 g (0.929 mole) of potassium cyanide in 181 mL of water was
added slowly to a stirred solution of 127 g (0.625 mole) of 1-(beta-phenethyl)-
4-piperidone and 87.1 g (0.935 mole) of aniline in 635 mL of glacial acetic
at 25°-30°C. After stirring for a total of 45 hours at room temperature, the
reaction mixture was poured into a mixture of 900 g of ice and 1610 mL of
concentrated ammonium hydroxide with stirring for two hours during which a
brown solid precipitated out. The solid was filtered and washed with water.
Recrystallization from isopropanol gave a total of 125 g (66% yield) of
product, 1-(beta-phenethyl)-4-((N-phenylamino)-4-piperidine carbonitrile,
as tan crystals, m.p. 119°-120°C.

Formic acid (600 mL was added to 600 mL of acetic anhydride at a rate such
that the temperature of the mixture did not exceed 42°C. To this solution was
added 119 g (0.39 mole) of 1-(beta-phenethyl)-4-(N-phenylamino)-4-piperidine
carbonitrile at 5-10°C. with stirring. After standing at room temperature
overnight, the reaction mixture was poured into ice-water and made alkaline
to pH 7.4 with dilute sodium hydroxide solution during which a tan solid
precipitated out. The solid was filtered and washed with water. Recrystalli-
zation from methanol gave 100.4 g (77.3% yield) of product 1-(beta-phenethyl)-
4-(N-formyl-N-phenylamino)-piperidine carbonitrile, as white crystals, m.p.
136°-138°C.

To a suspension of 100 g (0.30 mole) of 1-(beta-phenethyl)-4-(N-formyl-
N-phenylamino)-piperidine carbonitrile m 1.0 L of anhydrous methanol was
added slowly a solution of 670 g (18.4 mole) of hydrogen chloride in 2.0 L
of anhydrous methanol at 3-10°C. The resulting yellow solution was refluxed
two hours, and then the methanol was allowed to distill off until 1.7 L was
collected over the next three hours. During this time a white solid precipitated
out. The reaction mixture was cooled and filtered, yielding 79 g (64.2% yield)
of product, methyl 1-(beta-phenethyl)-4-(N-phenylamino)-4-piperidineimidate
dihydrochloride, as white solid, m.p. 196-198°C. (dec.).

A suspension of 79 g (0.19 mole) of methyl 1-(beta-phenethyl)-4-(N-phenylamino)-
piperidineimidate dihydrochloride in 675 ml of water was made alkaline to pH 9
with dilute sodium hydroxide solution. The solid was filtered and washed with
water. The solid was dried in a vacuum desiccator to give 61.5 g (98.8% yield)
of product, 1-(beta-phenethyl)-4-(phenylamino)- piperidine carboxamide, as a
white solid m.p. 181-183°

A solution of 28.4 g (0.088 mole) of 1-(beta-phenethyl)-4-(N-phenylamino)-
4-piperidine carboxamide and 17 g of potassium hydroxide in 114 mL of ethylene
glycol was allowed to reflux for 3 hours. The reaction mixture was poured into
228 mL of ice-water and made acidic to pH 6-6.5 with concentrated hydrochloric
acid during which a tan solid precipitated out. The solid was filtered and
washed with cold water. The solid was suspended in benzene and water was removed
by azeotropic distillation. The mixture was cooled and filtered yielding 28 g
(98.3% yield) of product, 1-(beta-phenethyl)-(N-phenylamino)-piperidine
carboxylic acid, as a white solid, m.p. 254-255°C. (dec.).

Concentrated sulfuric acid (12 mL) was added slowly to a stirred suspension of
25.6 g (0.079 mole) of 1-(beta-phenethyl)-4-(N-phenylamino)-4-piperidine
carboxylic acid in 95 mL of anhydrous methanol. The resulting solution was
refluxed for a total of 73 hours. The reaction mixture was cooled and poured
into 1 L of icewater, upon which a gummy brown solid precipitated out. The
mixture was made basic to pH 7.4 with dilute sodium hydroxide solution and
extracted with methylene chloride. The extracts were dried over magnesium
sulfate and evaporated to give 21 g of crude product which was recrystallized
from N-hexane to give 19.0 g (71.1% yield) of desired product, methyl
1-(beta-phenethyl)-4-(N-phenylamino)-4-piperidine carboxylate, as white
crystals, m.p. 92-93° C.

A mixture of 10.0 g (0.03 mole) of methyl 1-(beta-phenethyl)-(N-phenylamino)-
piperidine carboxylate and 100 g (0.77 mole) of propionic anhydride was heated
to reflux for 6 hours. Most of the propionic anhydride was then removed by
distillation under reduced pressure. The residue was slurried in about 100 mL
of ice-water and made alkaline to pH 8 with ammonium hydroxide. The mixture
was extracted with chloroform and the extracts dried over magnesium sulfate
and evaporated under reduced pressure. The residue, which weighed about 12 g,
was dissolved in 50 mL of isopropanol and treated with a solution of  3.8 g
(0.03 mole) of oxalic acid dissolved in 50 mL of isopropanol. The product was
allowed to crystallize out overnight at room temperature. When filtered and
dried, there was obtained 12.2g (85% yield) of carfentanil oxalate, or methyl
1-(beta-phenethyl)-(N- propionyl-N-phenylamino)-4-piperidine carboxylate
oxalate, m.p. 183-185°C.

-------------------------------------------------------------------------------


