Early War Service: The 22nd Pa. Vol. Inf. Organized in Philadelphia from the 1st Regiment, 3rd Brigade, 1st Division Pennsylvania Militia, Philadelphia Light Guards and moved to Baltimore, Md. On May 17th, 1861. Served on duty at Fort McHenry, Locust Point, Patterson's Pard and Mt. Clair till August.

At Gettysburg: the 106th arrived on the field from Uniontown late in the evening of July 1st (pooibly after midnight) and was positioned with the other regiments of the Philadelphia Brigade in a woods near the Taneytown Road. At or slightly defore dawn on July 2nd, the brigade was moved forward with the rest of the Second Corps to take up position along Granite Ridge(Cemetery Ridge), its right connecting with the left of Howard's Eleventh Corps on Cemetery Hill. At about six and a half o'clock, the brigade was fighting, the enemy was repulsed, then pursued by the 106th, 72nd and part of the 71st. The brigade captured about 250 prisoners, of whom, one was colonel, five were captains and fifteen were lieutenants. Ewell's assaults on Cemetery Hill and Culps Hill necessitated the call for reinforcements. All but the two companies of skirmishers of the 106th were detached to General Howard and positioned on the right of the Baltimore Pike near Rickett's Battery, where it remaned until the close of the battle. At this same time, the 71st was ordered to reinforce General Greene on Culp's Hill. On the morning of July 3rd, the 71st was redeployed on the right flank of the 69th at the 'Angle' on Cemetery Ridge. Two companies of the 106th were in position directly in the rear of the 69th at the copse of trees, with the 72nd on their right and the rear of the 71st. Here they would receive the full force of Pickett's Charge. Of the 280 men of the 106th who entered this battle, 9 were killed, 54 were wounded and 1 was listed as missing or captured.