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Autism is a developmental disability characterized by impairments in social
interaction, in verbal and non-verbal communication and a pattern of repetitive,
stereotypic activities. Autism represents one end of a spectrum of conditions
called the "Pervasive Developmental Disorders" (PDD) that share these clinical
features but differ in natural history, number of symptoms, or patterns of behaviours.
Autism represents the most extreme form of PDD and occurs in between 4-10/10 000 children
with about four affected boys to every affected girl. The overall prevalence of PDD may be
as much as 1 in 300 children. At present, two separate research studies of autism/PDD
are being conducted under the supervision of Dr. Peter Szatmari. Of which, the first is a
comprehensive study investigating the genetic factors that may have a correlation with
autism/PDD. This study, recognizing that many parents are eager to become involved,
readily extends an invitation, to any family with two or more children with autism/PDD, to
participate. In addition, the autism/PDD project is undergoing a long-term 'Follow-up
Study' of high functioning PDD children. The objective of this study is to complete an
in-depth examination of the development and outcome of PDD children overtime while also
investigating the differing outcomes of PDD subtypes such as Asperger's Syndrome.
Complementing this research, the project collaborates with several other groups. One
such team, headed by Jeremy Goldberg MD, is using a variety of imaging techniques to study
the brains of individuals with Autism/PDD and their families. Another study, headed by
Lonnie Zwaigenbaum, is working on a progressing study of the infant siblings of children
with autism/PDD. The infant sibling study is funded by the National Alliance of Autism
Research and is currently looking for volunteer families.
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