Bradykinin is a peptide hormone found in mammals. Bradykinin is involved in many physiological and physiopathological processes such as pain, allergies, chronic and acute inflammation and some cardiovascular diseases. However, a bradykinin antagonist is a synthetic protein made to relieve pain, allergies, low blood pressure, or even cranial trauma. Researches has been conducted on the design of bradykinin antagonists that can be taken orally, and to the development of powerful agonists. However, the use of peptides in medicine is associated with low bioavailability, so the peptides have to be converted into non-peptide type molecules without loss of activity.Modifying the bradykinin sequence has enabled bradykinin antagonists and agonists to be designed in such a way as to gradually reduce their peptide nature. These compounds constitute important pharmacological tools for evaluating the role of bradykinin in physiological processes and some diseases and may pave the way for new "drugs."

Click here to have a full view of the molecule ---> Bradykinin Antagonist Molecule