Osmosis is important! ·
Large
volumes of a solution of 5% human albumin are injected into people undergoing
a procedure called plasmapheresis. ·
The
albumin is dissolved in physiological saline (0.9% NaCl) and is therefore
isotonic to human plasma (the large protein molecules of albumin have only a
small osmotic effect). ·
If
5% solutions are unavailable, pharmacists may substitute a proper dilution of
a 25% albumin solution. Mixing 1 part of the 25% solution with 4 parts of
diluent results in the correct 5% solution of albumin. ·
BUT, in several cases, massive, life-threatening
hemolysis (bursting of red blood cells) occurred in the patients after the
treatment. What might have
happened? Discuss! |