Differences between Dogs and Humans

DOGS

HUMANS

Oral contraceptives prolong blood-clotting times. Oral contraceptives have increased the risk of fatal blood clots.
Chloramphenicol does not cause the fatal blood disease aplastic anaemia in dogs. Chloramphenicol causes aplastic anaemia in humans.
Dogs do not need to have Vitamin C added to their diet as they produce it themselves. Humans lack the ability to produce Vitamin C themselves and must get it from their diet.
Anticancer drug Azuridine causes lethal bone marrow in dogs after only 7 - 10 days. Azuridine is tolerated for comparatively long periods.
Aspirin causes birth defects in dogs. Aspirin does not cause birth defects in humans.
Arthritis drug Ibufenac does not cause liver damage in dogs. Ibufenac was withdrawn after deaths from liver damage.
Anticancer drug Mitoxantrone does not affect the heart. Mitoxantrone caused heart failure in clinical trials.
The body chemical acetylcholine dilates the coronary arteries. Acetylcholine constricts the coronary arteries leading to heart spasm.
Muscle relaxant drug d-tubocurarine causes severe fall in blood pressure. D-tubocurarine has been widely used in medicine.
Relatively high doses of isoprenaline are safe for dogs. Much smaller doses of isoprenaline (in aerosole inhalers) have proved dangerous for asthmatics, killing 3,500 in Britain alone.
The arthritis drug Fenclozic acid has no effect on dogs liver. Fenclozic acid caused liver toxicity during clinical trials.
Dogs take 30 minutes to metabolise the toxic drug oxyphenbutazone (faster elimination from the body reduces the danger.) Humans take 72 hours to metabolise oxyphenbutazone.
Digitalis for treating cardiopathies raises the blood pressure of dogs. Digitalis is used to lower blood pressure for humans.
Chloroform is poisonous to dogs. Chloroform has been used successfully for decades in human surgery.
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Information taken from GUARDIANS fact sheet No.8
Contact GUARDIANS at:
P.O Box 59,
Pascoe Vale South
Victoria 3044
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