The Andrew Sims, official one and only website about me....
Curriculum Vitae
Home Address: 23 Didsbury Court, Wilmslow Road, Manchester, M20 6AD. Tel: 07766912155.
Work Address:
Breast Biology Group, University of Manchester, Paterson Institute for Cancer Research, Wilmslow Road, Manchester, M20 4BX. Tel: 0161 4463222
Email: [email protected] Website: http://uk.geocities.com/andrew_h_sims/index.html
Born: 8 December 1977, Chesterfield, UK.
Education:
Sept 2001-Sept 2004 - Manchester University & Genencor Int. Inc. (August-December 2003, California, USA)
Biotechnology PhD. ‘Aspergillus genomics’. Validating and utilising Aspergillus nidulans EST microarrays to monitor gene
expression during heterologous protein production, to improve understanding of the secretory pathway of filamentous
fungi and identify possible targets for improving yields. Comparative genomic analysis of related species with completed
genome sequence and functional assignments based upon sequence alignments.
Sept 1996-June 2000 Edinburgh University
Biological Sciences BSc Hon (Microbiology) – Second class, upper division (2.1)
Sept 1989-June 1996 Tupton Hall School, Derbyshire.
9 GCSEs A and B grades (1994). 4 A’levels B and C grades (Biology, Chemistry, Physics, General studies 1996)
Current Employment:
Nov 2004-Present
Paterson Institute for Cancer Research, Wilmslow Road, Manchester.
Postdoctoral Research Associate – Gene Expression approaches towards prediction and prevention of Breast Cancer
Publications:(Click here for Pubmed link or individual papers for .pdf files)
Sims AH, Finnon P, Miller CJ, Bouffler SD, Howell A, Scott D, Clarke RB
�TPD52 and NFKB1 gene expression levels correlate with G2 chromosomal radiosensitivity in lymphocytes of women with and at risk of hereditary breast cancer.'
International Journal of Radiation Biology (2007) 83:409-20.
Sims AH, Ong KR, Clarke RB, Howell A
'Exploiting the potential of gene expression profiling: is it ready for the clinic?'
Breast Cancer Research (2006) Oct 11;8(5):214
Wilson CL*, Sims AH*, Howell A, Miller CJ, Clarke RB
'Effects of Oestrogen on gene expression in epithelium and stroma of normal human breast tissue.'
Endocrine-related Cancer (2006) 13: 617-628 *Joint 1st author
Howell A, Sims AH, Ong KR, Harvie MN, Evans DG, Clarke RB
'Mechanisms of Disease: prediction and prevention of breast cancer � cellular and molecular interactions�.
Nature clinical Practice Oncology (2005) 2(12) 635-646.
Sims AH, Gent ME, Lanthaler K, Dunn-Coleman NS, Oliver SG, Robson GD.
'Transcriptome analysis of recombinant protein secretion by Aspergillus nidulans and the unfolded protein response in vivo.'
Applied and Environmental Microbiology (2005) 71(5) 2737�47.
Sims AH, Robson GD, Hoyle D, Oliver SG, Turner G, Prade R, Russel H, Dunn-Coleman NS, Gent ME.
'Use of expressed sequence tag analysis and cDNA microarrays of the filamentous fungus Aspergillus nidulans'.
Fungal Genetics and Biology (2004) 41: 199-212.
Sims AH, Gent ME, Robson GD, Dunn-Coleman NS, Oliver SG.
'Combining transcriptome data, sequence alignments and cDNA to make confident functional assignments for Aspergillus nidulans genes'.
Mycological research (2004) 108: 853-857.
Sims AH, Robson GD, Dunn-Coleman NS, Oliver SG.
'Glutamic protease distribution is limited to filamentous fungi'.
FEMS Microbiology letters (2004) 239: 95-101.
Acknowledged by; Lawley B, Ripley S, Bridge P, Convey P.
�Molecular Analysis of Geographic Patterns of Eukaryotic Diversity in Antarctic Soils�.
Applied and Environmental Microbiology (2004) 70(10) 5963�72
Meetings:
Poster – Gordon Research Conference on Mammary Gland Biology – Il Ciocco, Italy. - June 2006
‘Effects of Oestrogen on gene expression in epithelium and stroma of normal human breast tissue’
Invited speaker – British Breast Group Annual Meeting– London, UK - July 2005
‘Effects of oestrogen on gene expression in normal human breast tissue’
Poster – 3rd International Symposium on the Molecular biology of Breast Cancer – Molde, Norway - June 2005
‘Effects of Oestrogen on Gene Expression in Epithelium and Stroma of the Normal Human Breast’
Abstract in Breast Cancer Research 7(Suppl 2):P2.02
Poster � Genomes to Systems: The Consortium for Post-Genome Science � Manchester - September 2004.
�Aspergillus genomics�
Invited Speaker �
BCS-PAR Summer School on Bioinformatics
- University of Exeter, August 2004
�Development of genomic approaches in the Aspergilli: A biologists perspective of bioinformatics�
Poster - European fungal Genetics Conference - Copenhagen, Denmark - April 2004
'Comparative and functional genomics in Aspergillus'
Invited speaker – 22nd Fungal Genetics Conference – Asilomar, California, USA - March 2003
‘Using Aspergillus nidulans microarrays to monitor gene expression in recombinant protein production strains’
Meeting report Fungal Genetics and Biology, 41: 109-14.
Poster – International Union of Microbiological Societies World Congress – Paris, France - July 2002
‘Construction and validation of Aspergillus nidulans microarrays’
Previous Employment:
Oct 2002-April 2004 Manchester Museum, Oxford Road, Manchester.
Teaching ‘Science for Life’ PCR Workshops for A’Level students and also assisting as a demonstrator in Manchester
University undergraduate practical sessions.
Nov 2000-April 2001 Clinical Microbiology & Public Health Laboratories, Addenbrooke’s Hospital, Cambridge.
Clinical Scientist – Research and development of real-time PCR methods for routine molecular diagnostic analyses.
Experience of nested PCR, Lightcycler, sequencing, NASBA and Cobas Amplicor HIV load methods.
July-Oct 2000 British Antarctic Survey, High Cross, Madingley Road, Cambridge.
Research Assistant - Characterising biodiversity of soil samples using culture methods and molecular techniques.
Producing clone libraries using ligations and transformations, PCR, DGGE, RFLPs and sequence investigations.
June-August 1999 & 1998 Camp Sequoia, Rock Hill, New York, USA. Camp councillor and instructor in outdoor
adventure program, high ropes course, rock climbing, rafting, canoeing, camping and mountain biking.
March 1996-Sept 1997 ‘The Smithy Pond’, Wingerworth, Chesterfield. General Bar/waiting duties.
Sept-Oct 1995 Work Experience - Chesterfield & North Derbyshire Hospital Pathology laboratory.
Skills & Achievements:
Full UK driving licence. Highly proficient at a wide variety of windows and LINIX based computer applications, analysis
software packages and databases, plus a basic knowledge of writing in HTML, perl and R programming languages.
Particular areas of bioinformatics expertise include interpretation of microarray data and comparative sequence analysis.
Derbyshire County Football Association Referee Class II. Universal Builders Ropes Course Instructor.
Nine years in Scout movement, chief scout award and young leader. Treasurer of University Mountaineering club.
Interests and Activities:
Mountaineering; rock and alpine climbing in summer and snow/ice climbing in winter.
Cycling, mountain biking, skiing, running, travel, music and films.
Referees:
Prof. Stephen Oliver Dr. Geoff Robson Dr. Robert Clarke
(Professor of Genomics) (Senior Lecturer) (Honorary Lecturer in Cancer Cell Biology)
Level 1A The Michael Smith Building, 1.800 Stopford Building, Paterson Institute for Cancer Research
University of Manchester, University of Manchester, University of Manchester,
Oxford Road, Oxford Road Wilmslow Road,
Manchester, M13 9PT. Manchester, M13 9PT. Manchester, M20 4BX.
Tel. +44 (0)161 2751578 Tel. +44 (0)161 275 5048 Tel. +44 (0)161 446 3220
Email. [email protected] Email. [email protected] Email. [email protected]