PAWC
was calculated by dividing the measured concentrations by the respective
molecular weight of each moiety followed by multiplication by the previously
determined relative potency in an animal model of antidepressant activity. The sum of the resultant values represented
the PAWC.
Evaluation
of trough concentration values for the last 3 days of dosing (Days 11, 12, and
13) determined that steady state was achieved.
Pharmacokinetic
parameters were determined using noncompartmental analysis. The plasma concentration time course and the
pertinent pharmacokinetic parameters for bupropion, its metabolites, and the
PAWC are shown in Figure 1 and Tables 5 and 6, below.
Stamped: Appears This Way On Original
83
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