Table 2. Pharmacokinetic parameters for bupropion and metabolites at steady state
|
|
Bupropion Mean
(% CV) |
Hydroxybupropion Mean
(% CV) |
[blacked out] Mean
(% CV) |
[blacked out] Mean
(% CV) |
Threo
+ Erythro Mean
(% CV) |
|
Tmax(h)a Cmax
(ng/mL) Cmin
(ng/Ml) AUC0-t
(ng*h/mL) AUC0-t
(ng*h/mL) T1/2
(hr) λz
(hr –1) |
1.5
(1.00- 1.50) 105.8
(19) 36.7
(25) 725.4
(21) 1088.6
(23) 11.0
(11) 0.064
(25) |
3.75
(2.00-5.00) [blacked out] (31) 397.8
(38) 5350.7
(34) 9675.4
(38) 23.8
(27) 0.031
(27) |
[blacked out] [blacked out] [blacked out] [blacked out] [blacked out] [blacked out] [blacked out] |
[blacked out] [blacked out] [blacked out] [blacked out] [blacked out] [blacked out] [blacked out] |
2.50
(0.50- 4.00) [blacked out] (31) 398.0
(172.8) 5540.2
(38) 10501
(40) 42.3
(18) 0.017
(17) |
amedian (range)
NR (not reported)
Individual plasma concentrations for bupropion and for the composite concentration value (CCV) reflecting a combination of bupropion, [blacked out] and erythro/threohydrobupropion are shown in the figures below.
64
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