Test (Fed)

(% CV)

n=31

Reference (Fasting)

(% CV)

n=31

Bupropion

t_max(h)^a

C_max (ng/mL)

AUC_0-t (ng*h/mL)

AUC_0-∞ (ng*h/mL)

t_1/2 (hr)

λ_z (hr ^–1)

5.07 (4.00-12.00)

[blacked out] (31)

1775.4 930)

1832.5 (30)

21.8 (27)

0.0347 (32)

5.00 (4.00-8.00)

[blacked out] (32)

1628.4 (31)

1678.4 (31)

21.2 (29)

0.0359 (34)

Bupropion Erythroamino Alcohol

t_max(h)^a

C_max (ng/mL)

AUC_0-t (ng*h/mL)

AUC_0-∞ (ng*h/mL)

t_1/2 (hr)

λ_z (hr ^–1)

14.00 (8.00-24.02)

[blacked out] (26)

1803 (38)

2116.0 (48)

35.2 (34)

0.0215 (27)

15.00 (5.00-24.00)

[blacked out] (32)

1634.6 (45)

1867.7 (52)

33.9 (33)

0.0223 (28)

Bupropion Threoamino Alcohol

t_max(h)^a

C_max (ng/mL)

AUC_0-t (ng*h/mL)

AUC_0-∞ (ng*h/mL)

t_1/2 (hr)

λ_z (hr ^–1)

8.00 (4.00-24.00)

[blacked out] (47)

9769.7 (63)

13280.6 (71)

55.2 (32)

0.0139 (30)

13.00 (6.00-18.00)

[blacked out] (55)

9032.2 (73)

11696.3 (77)

55.2 (38)

0.0139 (32)

Hydroxybupropion

t_max(h)^a

C_max (ng/mL)

AUC_0-t (ng*h/mL)

AUC_0-∞ (ng*h/mL)

t_1/2 (hr)

λ_z (hr ^–1)

14.00 (8.00-24.02)

[blacked out] (40)

19733.5 (48)

20886.1 (49)

24.1 (22)

0.0301 (22)

14.00 (5.00-24.00)

[blacked out] (38)

18939.8 (44)

19852.7 (46)

24.0 (20)

0.0302 (23)

PAWC

t_max(h)^a

C_max (µM)

AUC_0-t (µM*h)

AUC_0-∞ (µM*h)

_t1/2 (hr)

λ_z (hr ^–1)

10.00 (5.00-17.00)

[blacked out] (33)

63.3 (42)

68.0 (43)

27.6 (22)

0.0263 (22)

6.00 (4.00-14.00)

[blacked out] (27)

60.1 (40)

63.8 (41)

27.2 (26)

0.0271 (24)