treatment, 2-sequence crossover multiple dose steady state study.  The study was completed in 30 healthy subjects (22 M/8 F; mean age 34 (20-50) years of age).

 

The plasma concentration time course and pertinent pharmacokinetic parameters for bupropion, its metabolites, and the PAWC are shown in the Figures and Table below.

 

 

Mean Steady State Plasma Concentration Time Course for Bupropion and Its Metabolites After Administration of Test (solid circles) or Reference (open squares) Formulations in Study 2543 (as Provided by Sponsor)

 

STAMPED: Appears This Way on Original

 

18

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