Placebo-Treated

Bupropion sustained-

release-Treated

100-200 mg/d

Bupropion sustained-release

Treated

300-400 mg/d

All Bupropion sustained-release-Treated

Exposed to Treatment:

Total N=231

Total N=346

Total N=344

Total N=680

Number with

abnormality

% of N

Number with

abnormality

% of N

Number with

abnormality

% of N

Number with

abnormality

% of N

P value

compared with

Placebo

Systolic or Diastolic Hypertension

(systolic ≥ 180 mm Hg

with increase ≥ 20, or

Diastolic ≥ 150 mm Hg

with increase ≥15)*

2

0.9%

1

0.3%

2

0.6%

3

0.4%

Fisher p-0.61

Systolic or Diastolic Hypertension

(systolic ≤90 mm Hg

with decrease ≥ 20, or

Diastolic ≤ 50mm Hg

with increase ≥15)*

5

2.2%

10

2.9%

9

2.7%

19

2.8%

Yates p=0.78

Tachycardia >120 bpm

with increase ≥15)*

0

0.0%

1

0.3%

1

0.3%

2

0.3%

Fisher p=1.0

Bradycardia (<50 bpm

with decrease ≥15)*

0

0.0

3

0.9%

0

0.0%

3

0.4%

Fisher p=0.58

Weight Gain ≥ 5 lbs)*

27

11.7%

30

8.7%

23

6.9%

53

7.8%

Yates p=0.094

Weight Loss (≥ 5 lbs)*

33

14.3%

71

20.5%

111

33.2%

182

26.8%

Yates p=<0.001