EA Review #1, NDA 20-358

Page 7

          Adequate.

7.

Fate of Emitted Substances in the Environment:

Parent Compound:               Bupropion hydrochloride

In vivo:                                  Bupropion

Metabolites: (in urine)

          Bupropion                                                         <1%

          306U73                                                               5%* 

          494U73                                                               6%*

          17U67                                                                 2%*

*Identified in confidential Appendix A