UV spectra data for bupropion hydrochloride at 25°C.
|
|
|
|
|
Molar |
|
|
|
Wavelength (nm) |
A (1% |
Absorptivity |
||
|
Solvent |
Character |
1 cm1) |
ε X 10-3 |
||
|
Water |
208.8 |
maximum |
3.069 |
19.9 |
|
|
|
251.1 |
maximum |
1.700 |
11.0 |
|
|
|
297.4 |
maximum |
0.212 |
1.38 |
|
|
0.1
N HCl |
209.6 |
maximum |
3.127 |
20.3 |
|
|
|
251.0 |
maximum |
1.752 |
11.4 |
|
|
|
297.4 |
maximum |
0.220 |
1.13 |
|
|
0.1
N NaOH |
246.0 |
maximum |
0.209 |
10.8 |
|
Aqueous Biodegradation Half Life: Bupropion hydrochloride was tested for biodegradability
in an aqueous aerobic medium at a test concentration of 10 mg C/L 1µg/mL 14C-bupropion
hydrochloride and the remainder of carbon was from nonradiolabeled bupropion
hydrochloride). During the 14-day
incubation period, 1.21% of the applied captivity for 14C-bupropion
hydrochloride was mineralized to 14 CO2.
Over the same period, 64.7% of the applied reference compound (14C-glucose)
was mineralized to 14CO2. This indicated that bupropion hydrochloride was not significantly
mineralized under the test conditions.
The overall 14C-mass balance of the test and reference
chemical was 101.1 and 91.9% respectively.
Detailed information on this test is provided in Attachment III –
Aerobic Biodegradation in Water Report. (NOT PROVIDED THROUGH FOI ACT)
Photodegradation in Water: An aqueous photodegradation study was
conducted with 14C-bupropion hydrochloride in pH 5, 7 and 9 buffers. The test was conducted at a nominal test
concentration of 1.0 µg/mL (ppm). Based
on the results from the high-performance liquid chromatographic (HPLC)
analysis, photodegradation first-order rate constant and half-life values were
as follows.
|
Buffer |
First-Order Rate Constant |
Half-Life |
|
pH 5 |
0.0129 hours-1 |
54 hours |
|
pH 7 |
0.0606 hours–1 |
11 hours |
|
pH 9 |
0.0230 minutes-1 |
30 hours |
Estimated half-life values were calculated for bupropion hydrochloride, normalized for flat bodies of water at pH 5, 7, and 9 with varying season and latitude. These calculated half-lives for pH 5 ranged from a low of 100 hours (summer, 30°N) to a high of 592 hours (winter, 50°N). At pH 7 the calculated half-lives ranged from a low of 23 hours (summer) to a high of 131 hours (winter, 50°N). At pH 9 the half-lives ranged from a low of 52 hours (summer, 30 and 40°N) to a high of 481 hours (winter, 50°N).
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