BODY SYSTEM / ADVERSE EXPERIENCE

Bupropion sustained-release Dosing Group

150 mg/d

(N=147)

300 mg/d

(N=147)

Placebo

(N=150)

Cardiovascular

Palpitations

3.4%

3.4%

1.3%

Migraine

0.7%

0.7%

0.7%

Hot Flashes

1.4%

0.7%

0%

Hypertension

0%

0%

2.0%

Tachycardia

1.4%

0%

0%

Infections

Upper Respiratory Infection

2.7%

7.5%

4.7%

Flu Syndrome

8.8%

1.4%

4.0%

Special Senses

Tinnitus

4.8%

6.8%

0.7%

Taste Perversion

0%

2.7%

0.7%

Blurred Vision

2.7%

3.4%

0.7%

Musculoskeletal

Arthralgia

2.7%

0%

0%

Myalgia

0.7%

2.7%

2.0%

Leg Cramps

2.0%

0%

1.3%

Twitch

1.4%

1.4%

0%

Urinary System Disorders

Urinary Tract Infection

2.0%

1.4%

0%

Urinary Frequency

2.0%

1.4%

1.3%

Reproductive Disorders, Male

(percentage based on # male patients (BUP SR 150=57, BUP SR=49, PLACEBO=51)

Impotence

1.8%

0%

0%

Reproductive Disorders, Female

(percentage based on # male patients (BUP SR 150=90, BUP SR=98, PLACEBO=99)

Dysmenorrhea

1.1%

1.0%

2.0%