Anterior Pituitary

- Follicle Stimulating Hormone

- Leutenizing Hormone

Hypothalamus à Growth Hormone Releasing Hormone à Somatotropin à Growth Hormone à (Liver) à Somatomedin C

Pigmies and ….Dwarfs à deficient in Somatomedin C (yet, contain normal levels of GH)

Preprohormone à In Endoplasmic Reticulum – Prohormone à In Golgi Apperatus/membrane à Hormone release

Insulin is @ 6% prohormone

Growth Hormone

- Diminishes as we age to about 25 %

- May contribute to Osteoporosis

- Senior athletes still maintained GH levels around 50-60%

- Physical Stress – activates the secretion of GH

- Circadian Rhythm

- GH release is increased around 8pm and Midnight

- Cortisol is lower in the evening

- Sleep derived children may not grow as quickly

Hormones controlled by Metabolism

Posterior Pituitary

- Release ADH & Oxytocin

- Octipeptides only different by two amino acids (8 a.a.)

- Neuropeptide hormone produced in the nerve body

- Oxytocin

- Positive feedback – more stretch = more release

- Milk let down

- Neural stimulus (sound, smell) may control let down

- May be responsible for ejaculation