4/1/99

Microbiology II

 

WBC

·        Buffy coat on top

·        Citerated oxalated layer at the bottom

 

Lymphocytes

·        7-8mm

·        B and T lymphocytes

·        T lymphocytes

·        T-precursor cells

·        Thymus gland

·        Special antigens—theta antigens

·        Under study of a long time—still not well understood

·        Do not carry many antibodies

·        Bald cells

·        No immune adherence

·        T-cell mixed w/sheep RBC there is a few RBC that would join the surface of the T cell—Rosettes

·        P 488

·        T-helper cells

·        T-cytotoxic cells

·        T-DTH (delayed type hypersensitivity)

·        Disposal of unwanted cells in the body

·        Delayed type hypersensitivity—graft rejection

·        control of function of many types of cells

·        Immune memory—exists in humans, know that it has been exposed to a particular organism

·        Helping other immune function, synthesis of Ig, passing the message

·        Killing/destruction of unwanted cells through natural killer cells and T cytotoxic cells; recycling of cellular components

·        Passage of antigenic message to B cells

·        B lymphocytes

·        B-precursor

·        We do not know if there is any specific gland in humans for the maturation

·        In birds, it is the Bursa of Fabricus

·        Loaded w/Ig's—M, D

·        Wooly appearance

·        Ig on the surface have well recognized function

·        Major function is recognition of the antigenic stimulus

·        Pass message from outside of the cell to inside of the cell

·        When they come in contact w/RBC there is a kind of phenomena—immune adherence

·        Leads to agglutination reaction around B cell w/RBC

·        Upon receiving antigenic stimulus, they begin to clone rapidly and a large population programmed B cells are produced

·        Fig 17-28  activation of antibodies

·        Blast cells—intermediate stage before plasma cell is formed

·        Plasma cell has an important function—produce specific antibodies and program them will their antigenic feature—depends upon which antigen the B cell was exposed to

·        Some antigens are not natural and are purely man made from chemical processes and yet our body can produce antibodies to them

·        Some people the through evolution, human genome has engrained their antibodies to antigens

·        Plasma cells are short lived cells

·        Structure w/a lot of endoplasmic reticulum (rough)—proteins

·        Produces antibody to antigen exposed to