1/28/99
Microbiology
p575-6
papovaviridae--Human
papilloma-viruses--warts, cervical and penile cancer--p562-3
-mucous membranes
-grow wide spread on body; genital, oral
-viral infection lasts a lifetime
-remains in surrounding tissue
-most are benign
-a few are malignant--condylomata acuminata (cervical
cancer)
-transmission is direct contact
-surgically removed cervical, women 2 PAP tests a
year
-grow larger than normal in immunodeficiencies
-genital warts are sexually transmitted
Tx:
cryotherapy (freezing of tissue w/liquid CO2 or liquid N2 and excision
of infected tissue)
-podophylin, salicylic acid and glutaraldehyde,
surgery, 5-fluorouracil(antimetabolites)
-interferon
-high reoccurrence
Molluscum Contagiousum
-orthopoxviruses and
parapoxviruses
-DNA
-immunocompromised people
have severe lesions around mouth
Rubella Measles p 558, 559
-rubella virus
-togavirus/arbovirus
-transmitted by
arthropods--except rubella
-rubella is transmitted
through airborne, droplet route--German Measles
-not a very serious disease
-skin rash
-crosses the placenta and
causes severe damage to fetus
-30% of American females
enter childbearing age w/o being exposed to German Measles virus therefore w/o
developing any immunity to it--first trimester is the most risky (early
cataract for fetus)
-ELISA-Rubella--enzyme
linked immune assay
-immunize w/attenuated live
virus
-vaccine should not become
pregnant for 3 months
Moribilli Measles p 559
-not a member of the same
family as Rubella
-paramyxovirus
-RNA
-fever producing
disease--childhood
-Koplik's spots--red spot
w/central bluish area
-upper respiratory and ear
infections are common
-Measles Encephalitis
-30% mortality rate
-measles remain in the brain
tissue
-6-8 years after measles in
children who had before age 3
-300,000 children die every
year from measles
-problem--secondary
infections (respiratory)
-