1/19/99

Microbiology II

 

Hepatitis Viruses

-jaundice

-anemia where virus is blood borne, transmitted to liver were responsible for inflamation of liver and manefestations jaundice, bilirubin formation, loss of function

-agents can be responsible for other complications

-some protista--Entamoeba, bacteria--Neisseria/Chlamydia can also cause hepatitis

-Table 22.3, p627 know the entire table

-p626-628, 5 distinct kind of viruses responsible of these conditions

 

-A--epidemic (infectioius) hepatitis, low mortality, short-term, workers in restaraunt, immunoglobin, RNA picornaviridae (same as polio virus), oral-fecal route of tranmission, incubation is 15-40 days (ave of 28), self-limiting, carrier state negative (how long one can carry the virus w/them), no chronic liver disease, no vaccine, has artificial passive immunization (will stop symptoms)

 

-B--DNA, hepadnaviridae (know features of each virus, p276) envoloped, polyhedral, more serious than A (most serious), Serum hepatitis, Australia Antigen (surface ag commonly ID in patient as a diagnostic test), transmitted by exchange of body fluid, increased possiblity of agent getting into blood, can cross placenta, can cause serious consequences, incubation 45-180 days, higher mortaltity than A, associated w/liver (80%), immunization protocal

 

-C--RNA, posttransfusion patients, deadly virus, 10% of cases occurs, blood borne, cross placenta, lower mortality than B, short incubation, subclinical to severe symptoms, self-limiting, long carrier state, liver cancer, no vaccine

 

-D--Dane Particle, Delta hepatitis, piggy back ride w/ hepatitis B, defective RNA, hepatitis B capsid, resembles plant virod, blood borne, cross placenta, high mortaltity, severe conditions, no vaccine, chronic liver disease, long carrier state

 

-E--enterically transmitted, similar to A, orally transmitted more common in adults than children, RNA unclassified, moderate death, high mortality in pregnant women, no carrier state, no chronic liver disease, no vaccine