LabDx

10-15-99

Anemia—Health Answers

Sickle Cell—CBC

• Complete Blood Count
• Measures RBC, WBC, platelet
• Limited to a disorder that affects the number of these
• Anemia, allergies, infection, some neoplasms (marrow ones), thormbocytosis, thrombopnea
• What does it cost?
• $15
• High specificity
• 4500 diagnoses
• How many do GP's deal w/--about 60 on a regular basis
• Need to be familiar w/about 100
• A specialist deals with abnormal diagnosis
• Serial CBC has to do at least 2
• Special Considerations
• RBC's transport O2,
• MCV—mean cell volume
• MCH—mean cell hemoglobin
• MCHC—mean cell hemoglobin count
• Hematocrit—proportion of the fluid and the cellular component—the key in opening the door to anemia diagnosis
• Low—anemia—3 potential
• Macrocytic
• Microcytic
• Normocytic
• WBC
• Inflammation and immune response
• Number of colds per year is 4
• If get more then have a trouble in stress cope
• Band (stabs) elevation is a left shift—infection
• Have 4 in a CBC
• WBC are under attack
• Antigen response
• Polycythemia and erythrocytosis
• Low O2 level
• Heart and lung ds are the reasons
• Specific marrow ds—idiopathic is primary (vera) and is pre-neoplasm
• Dehydration—problem in the elderly—erythrocytosis
• Erythropoietin—kidney tumors—erythrocytosis

Low RBC's count

• Anemia or hemrrohage
• Chronic blood loss—hypochromic, Microcytic—GI/GU most common places
• Acute hemorrhage is Normocytic for about two days before changes to Microcytic
• Bone marrow failure
• Normocytic, normochromic—just not enough
• Crowding from a tumor in the marrow—myelopthsitic
• Erythropoietin deficiency—kidneys don't work
• Malnutritioin—no B12 (from vegetarian diet)
• Over hydration—lowers the red count—proportion (only after intravenous hydration)
• Pregnancy
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