Eye

Ophthalmoscope

Normal- +6 diopters to see the cornea

               0 diopters to see the disc

go more red to go deeper

 

if the doctor wears glasses:

focus on an object 20” away and bring it into sharp focus

this is the diopter to start the examination of the cornea with,

record your settings in your records, don’t adjust

 

 

Snellen Chart

20 feet away- due to physics, this is equal to infinity for human optics

Children 3 and up can use an E chart

Children less than 3, cover one eye and check their reaction  [even infants]

Cover one eye at a time

If the child seems consistently displeased when one eye is covered

But not the other

There is a difference in vision between the eyes.

The child will prefer the better eye to be uncovered.

            [see strabismus]

 

numerator is the distance of the patient from the chart

denominator is the line read last, the distance the ‘norm’ could read that line from

20/200 is the worst on the Snellen

20/100 means the patient must stand at 20 feet to see what someone else can see from 100 feet

Snellen chart must be used for sports and classrooms as distance vision is required.

 

 

 

recording the Snellen Chart

 

record the eyes OS- left eye     OD- right eye    OS-      both eyes

be sure to test with and without glasses

 

Method I-  the last line read with 50% accuracy is the recorded line

 

Method II – the entire line must be correct with the number of correct answers in the next line

or record the line with the most correct answers with the number of errors

Ex:  20/20 +1  the patient can read all of the 20/20 line and 1 more on the 20/15 line

Ex:  20/20 -1   the patient read all of the 20/20 line but missed one

 

20/20 is actually the lower end of normal vision

young adults typically have 20/12 or 20/15

 

 

concurrent referral is made when:

vision is less than 20/20

acuity is 20/40 or worse, especially in both eyes

[due to compensation, the patient may not have realized there is a problem if only one eye is affected]

acuity difference of 2 lines or more between the eyes

            even if the acuity is better than 20/40 in one or both eyes

complaints that near vision is difficult but distance vision is OK

patients with low vision

 

myopia:  near-sighted  [I can see MY book]

the eye is too long

correction is made with biconcave lens to push the focal point back onto the fundus

 

hyperopia:  far-sighted  [hyper = greater]

the eye is too short and the focal point has overshot the fundus

correction biconvex lens

 

presbyopia:  steady loss of accommodative power

begins in childhood and progresses throughout life

near vision is difficult as the lens is hardening and will not change adequately

 

pinhole occluder- removes divergent rays

if vision is still blurred- indicative of pathology not refractive error

 

squint or strabismus- common condition in children

easily treated by age three

difficult to treat at age six

the eyes are not aligned

their optic axes cannot be directed to the same object

can be unilateral, alternating, constant or periodic

due to reduced visual acuity due to pathology or refractive problems, unequal ocular muscle tone, oculomotor nerve lesion, paralysis, lesions

These cause diplopia [double vision]

Amblyopia then occurs

            A reduced visual acuity as the brain suppresses the information from the deviating eye

Binocular vision will not be present as one set of neurologic information is ignored permanently.  This is cortical, not ocular, at this point.  They will still perceive color and light from that eye but not form or shape.

 

 

 

Retinal vascular changes

Seen in hypertensive, collagen disease, anemia, diabetes, arterial or venous occlusion, etc.

All show similar changes: irregularity or dilation of vessels, hemorrhages, exudates, etc.

 

 

Capillary closure

 

Blockage of retinal artery  = diffuse pallor

Abrupt stoppage in a large area:  the retina becomes opaque with cloudy swelling and dies

 

Slow venous stasis = collateral vessels created

Slow gradual decrease in perfusion, typically due to venous blockage, retinal collateral vessels are created to carry the flow.  Think varicose veins.

 

Deep capillaries [focal] = microaneurysms

Focal lack of perfusion of deep capillaries in the vascular layers, they it looks like petechiae

 

Focal lack of perfusion of superficial capillaries- cotton wool exudates

The lack of perfusion occurs in the nerve fiber layer

            There is a decrease in the axoplasmic flow in the axons

            This is a serious sign if it accompanies papilledema and macular edema

            But can occur with hypertension of preeclampsia. 

            If this is an isolated sign, just monitor, resolves in app. 3 months.

 

Many sites of poor perfusion [very sick retina] = neovascularization

Think really poor blood flow in the legs with numerous spider veins trying to pick up the load.

These vessels are highly permeable and can lead to retinal edema, exudates & hge. 

They make loops and are irregular

 

Plasma leaks in the deep layers of the retina = hard exudates

            Can cause loss of sight if they are in the macula

 

Severe capillary damage

                        Deeper capillaries = dot and blot hemorrhages

                        Superficial capillaries = flame hemorrhages

 

 

Endothelial incompetence occurs when there is damage within the layers of the retina

-see microaneurysms and the exudates

 

 

 

laceration of the eye:  firm compress and transport immediately

            don’t try to look, orbital contents may leak increasing the damage

 

foreign particle:  discussion

 

Red eye

conjunctivitis: inflammation of the bulbar or palpebral conjunctiva

allergic, viral, bacterial

always palpate the preauricular lymph node- swollen and tender in viral

bacterial- highly contagious

itching :  allergy

acute focal stabbing :  foreign object

deep, intense aching: glaucoma, uveitis, optic neuritis, referred pain from sinus, vascular or tension headaches

burning, irritation, sand - superficial irritation of the lids, conjunctiva, cornea, sclera

photophobia: not reliable but may signal intraocular [uveitis] or extraocular ds [ keratitis or conjunctivitis]

fine, straight, deep red vessels radiating from the limbus and are immobile when the conjunctive is moved – uveitis and glaucoma

dark red injection, tortuous vessels that move with the conjunctiva- viral, bacterial or allergic

 

ANY blurring or change in vision must be referred to specialist for examination -

possible uveitis that can cause permanent scarring and damage to the eye

 

pink eye:  highly contagious

            conjunctivitis, itching, pin k with swelling, no pain unless keratitis [adenovirus]

            pinhole will improve vision if the acuity is affected

            discharge:  depends on etiology

            warm compresses

 

red eye: closed angle glaucoma

            steamy cornea decreased acuity, middilated unreactive pupil

            aggravated by dark may have sympathetic reactions [vomiting, etc.]

 

subconjunctival hemorrhage:  insignificant if not related to trauma

no change in acuity.  Examine if occurs repeatedly [due to blood disorder- clotting/dyscrasia] 

eyelids -

styes

chalazions

 

basal cell carcinoma -DDx: styes and chalazions

   look for dimple or ulceration, pearly, firm appearance

            small, gray nodule near the lid margin with firm borders

            possibly stalked or crusty

            slow growing

becomes ulcerated with rolled edges and indurated base

 

squamous- more malignant but less frequent

            looks like basal cell but not symmetrical

            goes to pre-auricular or submaxillary lymph nodes

 

 

herpes zoster opthalmia:

if the lower lid is involved then the pain  pattern is that of the 2nd division of the Trigeminal nerve

blisters infect the eye- keratitis, lid edema, pseudoptosis, loss of corneal reflex ciliary and conjunctival injection, corneal infiltration, pain and photophobia

burning pain, tender regional lymph nodes

            Note:  if a blister appears on the tip of the nose, the infection will go into the eye

           

 

 

xanthelasma

papilledema

swelling of the optic disc due to intracranial pressure, systemic diseases or ocular ds.

Occurs slowly over weeks to months unless due to trauma

Vision changes:  10-30 second attacks of hazy vision or blindness with intact visual fields and acuity

Persistent papilledema leads to optic atrophy

[optic atrophy has contraction of visual fields, loss of vision and eventual blindness.]

 

reddened, swollen disc [requiring fewer red diopters]

decrease in size of optic cup

eventual blurring of margins

hemorrhages around the disc

engorged tortuous vessels around disc

due to the changes in physiology, the following are likely to also be seen:

            cotton wool exudates, hemorrhages, and retinal edema

 

intracranial causes:  tumors, meningitis, brain abscess or hemorrhage ocular: central retinal venous occlusion, extra-orbital tumors

systemic: leukemia, syphillis, congenital heart disease, severe anemia, tuberculosis

hypertension

 

optic atrophy

terminal result of papilledema or any disease affecting the optic nerve, chiasm or tract

due to alcohol, syphilis, vascular ischemia [arteriosclerosis, emboli, etc.]

pale with eventual blurring of margins

scoots and complete blindness

Blepharitis - infection

Redness, edema and thickening of the margins of the eyelids- meibomian glands

Accompanied by crusting, itching, photophobia, conjunctivitis and burning

Soften crusting with warm, damp cloth

 

Can be due to staph, seborrhea or allergies

If recurrent, may cause a loss of eye lashes and scarring

 

 

 

Sty –hordeolum

Bacterial infection of meibomian glands, usually staph

            Small red mass, possibly with yellow head, on the lid margin or inside of eyelid

            Rather painful, red, swollen and tender lid

            Spontaneous resolution

            Recurs frequently

            Warm damp cloths may bring it to a head faster

 

Chalazion

Meibomian gland inflames then enlarges due to granulomatous changes

Initially it looks like a hordeolum but after the redness and pain resolves, a firm mass remains.

The skin moves easily over the mass and is not fixed as it would be with a tumor.

Usually resolve in several months.

Hot damp compresses may speed resolution.

May require surgical removal if it does not resolve in 6 week. 

 

 

cellulitis - infection

bacterial infection of the skin requiring immediate intervention

 

 

conjunctivitis -

look at distribution and appearance

 

subconjunctival, non-painful hge - few drops of blood under conjunctiva

     occur spontaneously or secondary to trauma

     resolve 2-3 weeks

     if recur repeatedly, R/O bleeding disorder

     if occur with pain, R/O conjunctivitis

 

 

conjunctivitis - bacterial or viral

Bacterial - diffuse redness and irritation, burning or relatively asymptotic

            purulent discharge with crustiness of lid margins, stuck together in AM

Viral - same without purulent discharge

 

Can be due to gonococcus, chlamydia, trachoma [type of chlamydia infection], herpes simplex [typically with dendritic ulcer on cornea], fungal infection, uveitis

 

uvea –the pigmented layers of the eye : choroid [thick vascular layers that feed photoreceptors], ciliary body and iris

 

uveitis - due to infection or allergy, commonly cause is unknown and the number of possible etiologies is numerous

ant. uveitis:  iritis or iridocyclitis – deep pain and photophobia

                        if the iris is inflamed the muscles are in spasm and the iris is small and irregular with induced myopia [decreased vision] as the ciliary body [muscles] that move the lens are inflamed too.  Light will increase the spasm and pain. 

            The limbus is injected- almost blue red- these vessels are episcleral and not the conjunctival [more superficial] and do not move when the conjunctiva is moved.  Diagnosis:  need slit lamp

 

            Post. Uveitis or choroiditis: macula [significant visual loss] or choroid [may be asymptomatic] 

 

 Can accompany or cause angle close glaucoma

 

 

anterior uveitis  vs.  posterior uveitis

anterior - affects ciliary body ( ciliary muscles change shape of lens) [cyclitis] and/or

             iris [iritis] - inflammation can cause adhesions

  ocular pain, photophobia, possible decrease in vision, injection around corneal limbus

  pupil is typically in spasm, eye is soft from decreased production of aqueous humor

  cornea not hazy as in acute closed angle glaucoma, hazy vision from turbidity

  dilation of pupil a must to prevent adhesions with iris permanently stuck to the lens which further can obstruct aqueous humor entry into ant. Chamber Þ closed angle glaucoma

 

 

posterior - affects choroid [vascular layers of retina]

      

 

 

Retinal Vessel Occlusions

Frequently associated with hypertension

 

CRAO- central retinal artery occlusion

emergency

ischemia of the posterior fundus

Retinal survival time is 100 minutes

Sudden painless unilateral loss of vision reduced to hand movements

No improvement with pinhole occluder

Cherry red spot seen at the fovea in the macula

Fundus is pale

Veins are narrow

Pupil is semidilated with poor response on direct but brisk response on indirect

Arterioles are very thin

Causes:  migraine, nicotine, oral contraceptives, cranial arteritis, atherosclerotic plaques, endocarditis, cranial arteritis

An embolus occurs at the cribiform plate leading to ischemic infarction of the retina.

Have the patient breathe into a paper bag to increase the carbon dioxide levels to increase vasodilatation and preserve the retinal tissue.

 

CRVO – central retinal venous occlusion

Non-emergent

The optic disc is red and swollen with hemorrhages of the disc and the periphery

Dilation and tortuosity of the venous system of the fundus.

The fundus is red and edematous.

Painless vision loss over several hours.

The eye will create collateral circulation but these vessels leak causing the hemorrhages.

Further, the fluid leakage weakens the retina and the increase in the amount of vasculature increases the intraocular pressure.

Management is laser to reduce the number of vessels

Etiology:  arteriosclerosis, glaucoma, diabetes mellitus, elevated hematocrit, idiopathic.

 

 

Retinoblastoma

Malignant tumor of embryonic tissue

Uni- or bilateral

Diagnosis is usually between 6 to 24 months

Yellow-white to gray colored ‘red light’ reflex

And/or strabismus is noted

Removal of the eye is the only treatment known

Metastasis to bone

 

 

Malignant melanona

Most frequent tumor of the uvea

Usually unilateral

Mortality 50% after 10 years

Uneven yellow-gray to gray-brown color with a mushroom or irregular shape

Lobulated border with its own blood supply

Due to elevation, look for a shadow or use slit to see bent light

Metastasizes to liver

 

Benign nevus

DDx malignant melanoma

Usually small, only 5 disc diameters big

[measure with target lens]

borders are smooth and feathery

slate gray to black

rarely enlarges

 

metastatic carcinoma from breast

often bilateral

indicates widespread metastasis

dome-shaped elevation without pigment derangement

use slit lens

 

 

 

 

 

 

 

 


Eye

 

cornea - 1 mm thick, tough

  layers - 1.  epithelium [damage affects the water balance in collagen meshwork - clouding],                                  2. Bowman’s membrane -[hypothyroidism - calcium deposits, iron form foreign bodies]

              3. corneal stroma [scarring] [transparent because of alignment of collagen fibers],            

              4. Descemet’s membrane  [Wilson’s disease - copper, gold poisoning, silver exposure]

              5.  endothelium

 

eye has three chambers - 

            1.  Anterior - behind the cornea and in front of the iris - aqueous humor

            2.  Posterior - between the iris and lens - aqueous humor

                  aqueous exits eye at Canal of Schlemm at angle between cornea and iris

                        it communicates with the venous system

                  ciliary body make aqueous humor and contains ciliary muscles that move the lens via                          the Zonule fibers which are ligamentous      

            3.  Vitreous chamber - behind the lens

                        not produced by the mature eye

                        may be replaced by saline solution or aqueous humor

 

 

Accommodation

Pupil constrictor muscles - parasympathetic of CN 3 [oculomotor].

Pupil dilator muscles - sympathetic of superior cervical ganglion

 

Ciliary muscles act in same way to change focus

 

retina is a layer of the eye - feed by the central retinal artery

  if detached from next layer, which is epithelium that adheres to the choroid, hypoxia occurs as the           choroid feeds the photoreceptors by diffusion

 

uvea -choroid [thick vascular layers that feed photoreceptors], ciliary body and iris

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Hypertension

affects arterioles

 

 

severity of damage depends partly on the level of hypertension

                                 and    partly on how long the hypertension has been present

                                 and    partly on the patient [some are more prone to damage]

 

 

acute hypertension - relates to the amount of hypertension and occur right away

changes relate to focal increases in muscle tone compensating for the increased pressure

 

arterioles - tortuous and narrow

pressure changes - ischemia and vascular permeability

                            - swelling of optic axons - Þ cotton wool exudates

                            - seepage of blood cells Þ flame hges which outline the optic fibers

                                                                                    [flame shaped because superficial layers]

 

High blood pressure Þ  Arteriolar narrowingÞ arteriolar narrowing with local areas of

 

constrictionÞ hemorrhages and exudatesÞ papilledema

                        [scattered throughout]

 

 

chronic hypertension - changes based on long term [years] of hypertension

arteriole changes [middle layer thickens] - at first the light reflection broadens,

   as thickening continues, pressure is put on the veins at AV crossings causing                          nicking.

Further thickening of the middle layer Þ silver Þ copper wire

 

 

Long term high blood pressureÞ broadened arteriolar light reflexÞ A-V nickingÞ copper wireÞ silver wire

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Diabetic retinopathy -      diabetes affects veins

note: venules lie deep within the retinal layers whereas the arterioles are in the superficial layers of the fovea

 

 

            veins dilateÞ pressure against arteriolesÞ AV nicking

            ß            ß

                         weakness of capillary wall

             ß     ß                           ß

             ß     ß                       microaneurysms, dot and blot hges

             ß     ß                           [roundish hges as deep within layers of retina]

             ß     ß                            [hges scattered throughout fovea]

             ß     ß

             ß     hard exudates [products of cell dmg]

             ß         [shape due to depth within layers of tissue]

             ß

             ß

neovascularization [can extend into vitreous humor and bleed]

 

 


Papilledema

increased intracranial pressure

                                      ß                      

                         venous obstruction at the optic disc

                              [loss of venous pulse at disc]

                                                            ß

                                    dilation of veins and capillaries [RED]

                                                ß          ß

                                          hges           edema

                                    [near disc]        ß

                                                        elevation of disc    

 

 

 

A single hge or exudate is a strong sign of any disc pathology

disc elevation and small cup size are not reliable signs of papilledema

      they are significant if:     it is an asymmetrical finding

 

 

1.  signs of papilledema

                             [inflammation of optic disc]  Þ  DDx:  papilledema    /      papillitis

                                                                                                ß                                 ß

                                                                                                ß                                  ß

                                                                                    early on                         severe  Ú        

                                                                                    vision                              acuity

                                                                                    usually unaffected          usually with

                                                                                                                        severe deep pn

 

2.  patient complains of severe pain pn behind eye, marked loss of vision

no signs of papilledema, fundus looks normal = optic neuritis

 

optic neuritis - inflammation in the optic nerve but behind the disc, not visible


 RETINAL DETACHMENT

 

fluid collects betw the retinal and the pigment separating the layers

causes interruption of diffusion from the choroid causing deoxygenation of the photoreceptive layer Þ bizarre stimulation

 

 

partial detachment Þ cc floaters, flashes of light, curtain partially drawn

 

damage can be irreversible - must be repaired within several days

myopics, post-trauma and post-cataract surgery people are predisposed

 

 

Macular degeneration

Several types

Age-related [older] and Mendelian dominant [younger people]

 

Age related:  most common cause of legal blindness [less than 20/200] in over 65 yrs.

 

Almost 30% of those betw. 75 and 85

Lipofuscin in retinal pigment in the macula

Appear as yellow /white drusen

If retina thins [dry macular degeneration]

If new vessels grow they bleed and is called ‘wet’ causing visual distortion

            Straight lines look wavy and scotomas may appear

Current research says increase bioflavinoids, etc.

Disease of central vision and peripheral vision will remain

 

 

Mendelian dominant type

Disease of central vision and peripheral vision will remain

Early- looks like egg yolk in the macula [vision good to normal]

Later- yolk [cyst] bursts and the macula looks like scramble eggs with burnt areas [scarring from heavy pigment deposits]

Can resolve, frequent after stress especially in older population

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