Cardio

11/19/99

 

Asthma

1. sympatheticotonia
1. increase NE
2. mediator release
3. leukotrienes

                                                               i.      SRS-A

                                                             ii.      ECF

                                                            iii.      NCF

4. Histamine
5. Bradykinine
6. Tx—allopathic

                                                               i.      Bronchodilation

1.      albuterol

2.      theophyline

                                                             ii.      stop mast cell degranulation

1.      steroids (corticosteroids) go to epinephrine to try and dilate the bronchioles—block degranulation

                                                            iii.      chromolyn

1.      OTC nasal spray—decrease the population of mast cells in the area to cause a problem

                                                           iv.      Leukotrienes inhibitors

1.      block the effects at the receptor sites

2.      still have release of the stuff in the body

3.      problem is a change in the respiratory pattern leading to pulmonary fibrosis\

4.      avoid increase NE and Cholinergic—avoid sympatheticotonia and vagotonia—increase the release of mediators—constriction of bronchial smooth muscle

5.      a-adrenergtic receptors (NE) special importance in Atopic ds; over-stimulation may give rise to identical pattern to b-blockade

2. vagal action
3. allery (Atopic)