Cardio
11/16/99
Intrinsic
- Neurogenic
- Vagus
nerve is involved
- Both
motor and sensory
- Irritant
receptors—afferent
- Upper
cervical
- Thoracic
- A.k.a.
Cough receptors
- To
cough have to close the small airways—the vagal efferents allow this to
happen
- Two
cells that are keeping things from the outside from getting into the
blood stream
- Mucocilliary
escalator—constant pulsating cilia that pushing things up towards the
mouth so it can be swallowed
- Cough
receptors line the bronchus
- Bronchoconstriction
is a protection from allowing things to get down into the lungs
- Asthma
- Cold
w/irritant to the bronchi
- The
asthma goes out of control w/a minor irritation
- Leads
to more bronchoconstriction
- The
Vagus also leads to more mucus production
- Why
are some people more sensitive?
- Sensitization—the
Vagus is already strongly facilitated in asthmatics
- Therefore,
when a little more irritant aggravates, it really over does it
- Korr—Central
Excitatory State
- Atropine
will help
- Put
ice on the Vagus nerve on the neck
- Smooth
muscle
- Has
one myoneural junction
- Beta-adrenergic
receptor—Epinephrine is the only thing that can lead to relaxation—no
direct contact, it has to come from the circulation
- Chemical
mediators that come from mast cells (SRS-A {slow reactive substance
anaphylaxis [most powerful bronchoconstrictor]}, ECF {eosinophils
chemotaxic factor}, histamine)
- Bronchoconstriction—Vagus
Nerve and mast cell degranulation
- NE
contributes to muscle contraction and stimulates the production of
epinephrine in the adrenals
- Phosphodiesterase—enzyme
inside the cell that is part of the rxn in the b-adrenergic
receptor
- It
breaks down camp which starts the entire cycle
- ¯
Excitation—Vagus, SRS-A, histamine, ECF, and phosphodiesterase
-
The inhibition—epinephrine or stimulate a b-adrenergic
receptor
- Ephedra—natural
herb
- Ma
Huang
- Problem
w/it—makes to ephedrine and put in cold remedies as
pseudoephedrine—which can make amphetamines
- Thoracic
adjusting
- If
we believe that the sympathetics relieve this, then an adjust would
relieve the problem—classic example
- Korr
model—adjustment is reducing the stimulation of the sympathetics which
contribute to the problem
-