From the Medical Literature - April 1998

Record  1

  PMS2-related  genes  flank  the rearrangement breakpoints associated with
Williams syndrome and other diseases on human chromosome 7.
  Osborne LR; Herbrick JA; Greavette T; Heng HH; Tsui LC; Scherer SW
  Department  of Genetics, The Hospital for Sick Children, Toronto, Ontario
M5G 1X8, Canada.
  Genomics (UNITED STATES)   Oct 15 1997,  45 (2) p402-6,  ISSN 0888-7543
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE

  The  human  PMS2  mismatch  repair gene and a family of at least 17 other
related  genes  (named  human  PMSR  or PMS2L genes) have been localized to
human chromosome 7. Human PMS2 has been mapped previously to 7p22 and shown
to  be  causative  in hereditary nonpolyposis colon cancer (HNPCC), but the
human  PMS2L  genes have not been positioned in the context of the physical
or  genetic map of chromosome 7. In this study we have used various mapping
methodologies to determine the precise location of the human PMS2L genes at
7q11.22, 7q11.23, and 7q22. Within 7q11.23, human PMS2L genes were found to
be  present  at at least three sites as part of duplicated genomic segments
that  flank the most common rearrangement breakpoints in Williams syndrome.
Copyright 1997 Academic Press.
 
Record  2
 
  Localization  of  the human HIP1 gene close to the elastin (ELN) locus on
7q11.23.
  Wedemeyer N; Peoples R; Himmelbauer H; Lehrach H; Francke U; Wanker EE
  Max-Planck-Institut fur Molekulare Genetik, Berlin, Dahlem, Germany.
  Genomics (UNITED STATES)   Dec 1 1997,  46 (2) p313-5,  ISSN 0888-7543
  Languages: ENGLISH
  Document type: JOURNAL ARTICLE

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