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Studies
on concentration of B12 in patients with mutliple sclerosis
with concomitant neurological evaluation and testing of MCV and LDH.
Kountouris D.2 Drossos Th., Papatriantafillou M, Liapis A,and Siani A1
1Pammakaristos General Hospital, Iakovaton 43,11144, Athens, Greece
2Neurological Medical Center, Michalakopoulou 43, 11528, Athens, Greece
The purpose if this study
is to evaluate the concentration of vitamin B12 in the serum
of patients of multiple sclerosis in relation with neurological clinical
symptomatology and the effect of B12 on MCV and LDH. The
serum of 57 patients with known diseases was evaluated (age 17-54).
B12 was measured with immunoenzymatic assay MCV from blood
examination and LDH with photometric assay. Clinical neurological evaluation
was performed on Kurtzke score. The results and the statistical analysis
were as follows:
Table 1.
| B12 | m=532 | sd=450.6 | se=82.27 |
| MCV | m=89.9 | sd=7.28 | se=1.24 |
| LDH | in=161.8 | sd=105 | se=6.54 |
The levels of measured parameters
in patients with multiple sclerosis were between normal limits. In no
patients was found any indication of megaloblastic anemia. No correlation
between B12 levels in patients`s serum and gravity of patients
symptoms was found. LDH did not appear any variation. Conclusively B12
as a therapeutic agent in patients with multiple sclerosis can help
only as a secondary choice and always like a complex of B1
and B6.
Abstract published in EUROPEAN JOURNAL OF NEUROLOGY, 1996;3(5)
paper presented at the 2nd
Congress of European Federation of Neurological Societies, Rome, Italy,
30 Oct.-3Nov.1996.