Follow up with rep-Aep and a1-antithrepsin in patients with chronic MS

Dimitrios Kountouris¹ Theofanis Drosos²,

Neurological Medical Center Athens²; Internal medicine General Hospital Pammakaristos, Athens Greece.

Purpose of this study is to define the correlation, if it really exists, between the acute accent phase ptotein (a1 antithrepsin) of neurophysiological factors (rep-Aep) and the clinical picture that presents the patients with chronic MS.

Material-Methods: In a period of time 18-24 months examined 82 patients (51 female 31 male) that suffer from chronic MS. All the patients during the first clinical estimation and at the next levels examined as clinical (KURTZKE) as neurophysiologic (Aep-rep). Moreover it took place the definition of a1-antithrepsin (SANOFI).

Results:At the 68 patients found clear agreement between a1ATH and the clinicla picture, while the neurophysiological parameters (rep-Aep) didn`t appear clear inclinations. At the rest of the 14 patients that existed clear transformations of the challenge dynamics, also was observed agreement of the pprices with ATH (antithrepsin).

Generally, it was proved that a1 ATH is a very sensitive method for the attendance of the follow up in patients with MS and superior to the neurophysiological examinations.

Abstract published in ELECTROENCEPHALOGRAPHY and CLINICAL NEUROPHYSIOLOGY 1997;103(1)

Paper presented at the International congress of EEG and clinical Neurophysiology, Florence, Italy, August 24-29, 1997

p-52-2

Smoking and damages of the optical nerve

Dimitrios Kountouris¹ Theofanis Drosos²,

Neurological Medical Center Athens²; Internal medicine General Hospital Pammakaristos, Athens Greece.

The purpose of this study is to present the influence of smoking on the optical nerve according to the changes that appeared during the examination of the visual evoced potential.

Sample-Method: Was examined 70 healthy people, 40 men and 30 women aged beteen 28-52 years, M:39,5+_ 8,2 smokers over 5 years with the method of the visual evoked potential. (VEP)

The results were compared with those from a team with healthy non smokers of these same age and sex. The statistical comparison shows a high significant difference between smoking and non smoking people (p<0,01).

Smokers were observed to present prolonged latencies as well as decreased shapes of visual evoked potentials.

Generally the results support the opinion that in chronic smokers, an incresed vulnerability of the optical nerve is observed.

Abstract published in ELECTROENCEPHALOGRAPHY and CLINICAL NEUROPHYSIOLOGY 1997;103(1)

Paper presented at the International congress of EEG and clinical Neurophysiology, Florence, Italy, August 24-29, 1997