| Rk | LY | Quarterback | Team | Active | GS | Total | PPG | Rk | LY | Pos | Defensive Line | Team | Active | GS | Total | PPG | ||
| 1 | 1 | Favre, Brett | Packers | 2008 | 155 | 2599 | 16.77 | 1 | 1 | DE | Strahan, Michael | Packers | 2007 | 128 | 1722.5 | 13.457 | ||
| 2 | 2 | Manning, Peyton | Protest | 2008 | 125 | 2354 | 18.83 | 2 | 2 | DE | Taylor, Jason | Puss | 2008 | 112 | 1436 | 12.8214 | ||
| 3 | 4 | McNabb, Donovan | Protest | 2008 | 94 | 1544 | 16.43 | 3 | 3 | DE | Rice, Simeon | Sleeve | 2007 | 118 | 1408 | 11.9322 | ||
| 4 | 3 | Bledsoe, Drew | Irish | 2006 | 94 | 1402 | 14.91 | 4 | 6 | DE | Peppers, Julius | Protest | 2008 | 83 | 1051 | 12.6627 | ||
| 5 | 5 | Culpepper, Daunte | Vikings | 2006 | 68 | 1300 | 19.12 | 5 | 4 | DE | Porcher, Robert | Lions | 2004 | 90 | 928 | 10.3111 | ||
| 6 | 11 | Brees, Drew | TC | 2008 | 67 | 1125 | 16.79 | 6 | 7 | DE | Kearse, Jevon | TC | 2008 | 93 | 921 | 9.90323 | ||
| 7 | 8 | Garcia, Jeff | Sleeve | 2008 | 61 | 1014 | 16.62 | 7 | 5 | DT | Sapp, Warren | Raiders 2 | 2007 | 94 | 916 | 9.74468 | ||
| 8 | 15 | Warner, Kurt | Vikings | 2008 | 56 | 1010 | 18.04 | 8 | 11 | DE | Abraham, John | Raiders 2 | 2008 | 72 | 913 | 12.6806 | ||
| 9 | 6 | Brunell, Mark | Stamps | 2004 | 66 | 1008 | 15.27 | 9 | 13 | DE | Freeney, Dwight | Puss | 2008 | 79 | 801.5 | 10.1456 | ||
| 10 | 7 | Gannon, Rich | Raiders | 2004 | 57 | 991 | 17.39 | 10 | 8 | DE | Smith, Bruce | Cripps | 2002 | 72 | 798.5 | 11.0903 | ||
| Rk | LY | Running Back | Team | Active | GS | Total | PPG | Rk | LY | Pos | Linebacker | Team | Active | GS | Total | PPG | ||
| 1 | 1 | Tomlinson, LaDainian | Whisper | 2008 | 96 | 1494 | 15.56 | 1 | 1 | ILB | Lewis, Ray | Protest | 2008 | 137 | 1790 | 13.0657 | ||
| 2 | 2 | James, Edgerrin | TC | 2008 | 108 | 1339 | 12.40 | 2 | 2 | LB | Brooks, Derrick | Protest | 2007 | 126 | 1449 | 11.5 | ||
| 3 | 3 | Faulk, Marshall | TC | 2005 | 95 | 1257 | 13.23 | 3 | 3 | LB | Brown, Chad | Redskins | 2003 | 88 | 1269.5 | 14.4261 | ||
| 4 | 4 | Martin, Curtis | Irish | 2006 | 103 | 1192 | 11.57 | 4 | 5 | ILB | Edwards, Donnie | Protest | 2008 | 105 | 1221.5 | 11.6333 | ||
| 5 | 5 | Barber, Tiki | TC | 2006 | 99 | 1140 | 11.52 | 5 | 6 | ILB | Urlacher, Brian | Raiders 2 | 2008 | 99 | 1208.5 | 12.2071 | ||
| 6 | 6 | Dunn, Warrick | Protest | 2008 | 117 | 1138 | 9.73 | 6 | 4 | ILB | Thomas, Zach | Vikings | 2008 | 105 | 1168 | 11.1238 | ||
| 7 | 7 | Taylor, Fred | Wave | 2008 | 103 | 1090 | 10.58 | 7 | 7 | ILB | Fletcher, London | Packers | 2008 | 98 | 1079 | 11.0102 | ||
| 8 | 8 | George, Eddie | Vikings | 2004 | 100 | 1023 | 10.23 | 8 | 9 | LB | Peterson, Julian | Protest | 2008 | 91 | 1017 | 11.1758 | ||
| 9 | 9 | Green, Ahman | Packers | 2008 | 93 | 1009 | 10.85 | 9 | 8 | LB | Seau, Junior | Vikings | 2003 | 90 | 924 | 10.2667 | ||
| 10 | 10 | Holmes, Priest | Stamps | 2005 | 61 | 923 | 15.13 | 12 | 12 | ILB | Barrow, Michael | Packers | 2004 | 78 | 808.5 | 10.3654 | ||
| Rk | LY | Pos | Receiver | Team | Active | GS | Total | PPG | Rk | LY | Pos | Defensive Back | Team | Active | GS | Total | PPG | |
| 1 | 1 | WR | Owens, Terrell | Vikings | 2008 | 130 | 1710 | 13.15 | 1 | 1 | S | Harrison, Rodney | Hawks | 2006 | 88 | 1159 | 13.1705 | |
| 2 | 2 | WR | Moss, Randy | Protest | 2008 | 128 | 1578 | 12.33 | 2 | 6 | CB | Woodson, Charles | Packers | 2008 | 94 | 1139.5 | 12.1223 | |
| 3 | 3 | WR | Harrison, Marvin | Protest | 2008 | 132 | 1479 | 11.20 | 3 | 2 | CB | Law, Ty | TC | 2006 | 100 | 1125.5 | 11.255 | |
| 4 | 4 | WR | Bruce, Isaac | TC | 2008 | 117 | 1147 | 9.80 | 4 | 5 | CB | Barber, Ronde | TC | 2008 | 89 | 1088.5 | 12.2303 | |
| 5 | 6 | WR | Holt, Torry | Vikings | 2008 | 101 | 1052 | 10.42 | 5 | 7 | CB | Winfield, Antoine | Vikings | 2008 | 96 | 1055 | 10.9896 | |
| 6 | 5 | WR | Smith, Rod | Luccis | 2006 | 103 | 1001 | 9.72 | 6 | 4 | CB | Bailey, Champ | Packers | 2008 | 92 | 1053 | 11.4457 | |
| 7 | 7 | WR | Smith, Jimmy | Jaguars | 2005 | 95 | 959 | 10.09 | 7 | 3 | S | Sharper, Darren | Puss | 2008 | 80 | 950 | 11.875 | |
| 8 | 10 | TE | Gonzalez, Tony | Wave | 2008 | 136 | 959 | 7.05 | 8 | 11 | S | Reed, Ed | Protest | 2008 | 74 | 928 | 12.5405 | |
| 9 | 8 | WR | Galloway, Joey | TC | 2008 | 97 | 913 | 9.41 | 9 | 12 | CB | Bly, 'Dre | Vikings | 2008 | 60 | 785.5 | 13.0917 | |
| 10 | 9 | WR | Brown, Tim | Raiders | 2004 | 102 | 869 | 8.52 | 10 | 8 | S | Butler, LeRoy | Packers | 2001 | 62 | 768 | 12.3871 | |
| Rk | LY | Kicker | Team | Active | GS | Total | PPG | |||||||||||
| 1 | 3 | Hanson, Jason | TC | 2008 | 148 | 1015 | 6.86 | |||||||||||
| 2 | 5 | Longwell, Ryan | Sleeve | 2008 | 129 | 938 | 7.27 | |||||||||||
| 3 | 2 | Wilkins, Jeff | TC | 2007 | 129 | 937 | 7.26 | |||||||||||
| 4 | 1 | Elam, Jason | Cougars | 2007 | 119 | 927 | 7.79 | |||||||||||
| 5 | 4 | Stover, Matt | Wave | 2008 | 127 | 882 | 6.94 | |||||||||||
| 6 | 7 | Vinatieri, Adam | Raiders II | 2008 | 113 | 781 | 6.91 | |||||||||||
| 7 | 8 | Janikowski, S. | Raiders 2 | 2008 | 108 | 749 | 6.94 | |||||||||||
| 8 | 6 | Vanderjagt, Mike | Luccis | 2006 | 89 | 694 | 7.80 | |||||||||||
| 9 | 10 | Kasay, John | Vikings | 2008 | 93 | 610 | 6.56 | |||||||||||
| 10 | 9 | Carney, John | Hawks | 2005 | 78 | 528 | 6.77 | |||||||||||