| Grissom | 27 | Lee | 34 |
| Randolph School | 50 | Lighthouse Christian | 28 |
| Rocket City Cowboys | 52 | Open Door Christian | 00 |
| Lee | 34 | @Bob Jones | 31 |
| Hazel Green | 00 | @Buckhorn | 19 |
| Butler | 07 | @Grissom (MF) | 27 |
| Brewer | 28 | @Madison County | 07 |
| Douglas | 12 | @New Hope | 23 |
| Pell City | 15 | @Sparkman | 09 |
| Lawrence Co. | 12 | @Huntsville (MF) THURS | 47 |
| Johnson | 07 | @Mountain Brook | 28 |
| Colbert Heights | 00 | @Madison Academy | 26 |
| Franklin Classical | 54 | @Randolph | 68 |
| Scottsboro Christian | 28 | @Rocket City Cowboys | 08 |
| Brindlee Mountain | 13 | @Westminster | 48 |
| Florence | 07 | @Bob Jones | 11 |
| Austin | 24 | @Sparkman | 22 |
| Grissom | 24 | @Hazel Green | 06 |
| Buckhorn | 21 | @Ft. Payne | 17 |
| Scottsboro | 07 | @Butler (Thurs)(MF) | 28 |
| Lee | 42 | @Arab | 21 |
| Johnson | 26 | @Huntsville (MF) | 27 |
| E. Limestone | 41 | @Madison County | 14 |
| Madison Academy | 21 | @Elkmont | 00 |
| New Hope | 07 | @Crossville | 34 |
| Skyline | 08 | @Westminster | 25 |
| Franklin Christian | 28 | @Randolph | 70 |
| Evangel Lightning | 06 | @Rocket City Cowboys | 28 |
| Bob Jones | 35 | @Austin | 07 |
| Decatur | 20 | @Grissom (MF) | 14 |
| Arab | 13 | @Johnson (Thurs)(MF) | 35 |
| Butler | 07 | @Buckhorn | 12 |
| Huntsville | 35 | @Scottsboro | 17 |
| Hazel Green | 14 | @Sparkman | 21 |
| Madison County | 20 | @North Jackson | 52 |
| Plainview | 35 | @New Hope | 07 |
| Rogers | 00 | @Madison Academy | 07 |
| Ft Payne | 19 | @Lee (GS) | 30 |
| Westminster | 28 | @Mount Hope | 00 |
| Randolph | 14 | @Evangel School | 40 |
| Emerald City Eagles | 00 | @Rocket City Cowboys | 56 |
| Hazel Green | 00 | @Bob Jones | 16 |
| Madison Academy | 10 | @Sheffield | 06 |
| Buckhorn | 20 | @Huntsville (Thurs) (MF) | 07 |
| Lee | 35 | @Butler (MF) | 14 |
| Sparkman | 00 | @Decatur | 07 |
| Johnson | 20 | @Ft Payne | 14 |
| Fairview | 07 | @Madison County | 13 |
| New Hope | 27 | @N. Sand Mountain | 00 |
| DAR | 08 | @Westminster | 16 |
| Rocket City Cowboys | 56 | @Dawson Street Christian | 18 |
| Scottsboro Christian Academy | 48 | @Randolph School | 00 |
| Bob Jones | 31 | @Butler (MF) (THURS) | 28 |
| Buckhorn | 56 | @East Lauderdale | 06 |
| Huntsville | 07 | Grissom (MF) | 34 |
| Boaz | 20 | @Hazel Green | 38 |
| New Hope | 00 | @Madison Academy | 35 |
| Minor | 40 | @Johnson (GS) | 20 |
| Madison County | 14 | @Pisgah | 12 |
| Sparkman | 21 | @Spain Park | 18 |
| Westminster | 00 | Coosa Christian | 22 |
| Rocket City Cowboys | 70 | Franklin Classical | 20 |
| Emerald City Eagles | 30 | Randolph School | 56 |
| Lee | 27 | Wetumpka | 54 |
| Sparkman | 21 | @Grissom (THURS) (MF) | 20 |
| Bob Jones | 14 | @Decatur | 17 |
| Buckhorn | 00 | @Lee (GS) | 12 |
| Butler | 07 | @Johnson (MF) | 21 |
| Huntsville | 35 | @Arab | 14 |
| Florence | 21 | @Hazel Green | 28 |
| New Hope | 08 | @Pisgah | 22 |
| Douglas | 26 | @Madison County | 28 |
| Lauderdale Co | 00 | @Madison Academy | 14 |
| Rocket City Cowboys | 64 | @Randolph School (THURS) | 26 |
| Mount Hope | 06 | @Westminister | 33 |
| Sparkman | 13 | @Oak Mountain | 10 |
| Grissom | 06 | @Bob Jones | 23 |
| Huntsville | 43 | @Butler (MF) | 12 |
| Scottsboro | 07 | @Lee (THURS) (MF) | 21 |
| Johnson | 07 | @Buckhorn | 16 |
| Hazel Green | 15 | @Austin | 18 |
| Madison County | 13 | @Guntersville | 41 |
| Susan Moore | 40 | @New Hope | 07 |
| Madison Academy | 44 | @West Limestone | 00 |
| Emerald City | MM | @Rocket City Cowboys | MM |
| Westminster | 33 | @DAR | 14 |
| Sparkman | 14 | @Florence | 18 |
| Grissom | 49 | @Austin | 21 |
| Buckhorn | 33 | @Scottsboro | 21 |
| Decatur | 27 | @Hazel Green | 14 |
| Ft Payne | 06 | @Huntsville (THURS) (MF) | 42 |
| Lee | 35 | @Johnson (MF) | 21 |
| West Point | 21 | @Madison County | 20 |
| Colbert Co. | 09 | @Madison Academy | 00 |
| Vestavia Hills | 24 | @Bob Jones | 16 |
| Butler | 42 | @Arab | 00 |
| New Hope | 07 | @Sardis | 10 |
| Westminster | 28 | @Lyman Ward Military | 06 |
| Randolph | 48 | @Franklin Christian | 30 |
| Rockey City Cowboys | MM (Won) | @Aaron Academy (Hend. TN) | MM |
| Bob Jones | 07 | @Sparkman | 28 |
| Arab | 07 | @Buckhorn | 49 |
| Ft Payne | 14 | @Butler (GS) | 41 |
| Johnson | 35 | @Scottsboro | 28 |
| Huntsville | 30 | @Lee (MF) | 42 |
| Colbert County | 21 | @Madison Academy | 24 |
| Cherokee County | 44 | @New Hope | 06 |
| Lincoln County | 14 | @Hazel Green | 21 |
| Madison County | 31 | @Ardmore | 14 |
| Florence | 24 | @Grissom (MF) (THURS) | 21 |
| Eminence (KY) | 50 | @Randolph | 20 |
| Rockey City Cowboys | MM | @Franklin Christian | MM |
| Westminster | MM | @Holy Spirit Cath. (Tusc.) | MM |
| Athens | 06 | @Sparkman | 31 |
| Huntsville | 15 | @Bob Jones | 31 |
| Johnson | 20 | @Grissom (MF) (THURS) | 21 |
| Austin | 20 | @Butler (MF) | 42 |
| Hazel Green | 13 | @East Limestone | 18 |
| Briarwood Christian | 30 | @Lee (GS) | 17 |
| Boaz | 13 | @Buckhorn | 28 |
| Madison Academy | 35 | @West Limestone (THURS) | 32 |
| Madison County | 27 | @New Hope | 07 |
| Westminster | @Coosa Christian |
3A
Good Hope (7#3) at Madison Academy (8#2) (W 42-15)
5A
Cullman (7#4) at Lee (8#1) (MF) (W 24-14)
Walker (7#3) at Buckhorn (8#2) (W 31-07)
Huntsville (8#3) at Athens(7#2) (L 20-27)
Johnson (8#4) at Russellville (7#1) (L 20-48)
6A
Huffman (7#3) at Bob Jones (8#2) (W 14-08)
Sparkman (8#4) at Clay-Chalkville (7#1) (L 07-21)
NOVEMBER 5 - BOWL Game (8-Man)
Rocket City Cowboys vs. Georgia Force (W 54-22)
NOVEMBER 11 - ROUND TWO
3A
Madison Academy vs. Cherokee Co.; (L 10-24)
5A
Lee vs. Parker; (W 38-21)
Buckhorn vs. Fairfield (W 13-07)
6A
Bob Jones vs. Hoover (L 27-48)
NOVEMBER 18 - ROUND THREE
5A
Lee vs. Russellville; (L 27-49)
Buckhorn vs. Athens; (W 34-31)
NOVEMBER 25 - SEMI-FINAL
5A
Buckhorn vs. Russellville; (W 17-13)
DECEMBER 2 - SUPER 6 STATE CHAMPIONSHIP
5A
Buckhorn vs. Homewood; (L 13-45)
END OF SEASON
Madison County Football Returns August 25th, 2006.
Huntsville and Buckhorn move to 6A.