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Toxicology and Risk Assessment Consulting
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These are just examples of our published research papers
For CV and Complete List of Publications, CLICK THIS LINK:
Janusz Z. Byczkowski,
M.Sc., Ph.D., D.Sc., D.A.B.T.
Byczkowski, J.Z.: Methyl Mercury Toxicity: Pharmacokinetics And Toxicodynamic Aspects. In: Annual Reviews in Food and Nutrition: Toxic and Pathological Aspects (Preedy,V.R. and Watson,R., Eds.). CRC Press LLC, Boca Raton, FL in press, 2004.
Byczkowski, J.Z.: Pharmacokinetic Approach and Mathematical Modeling. In: Handbook of Elemental Speciation, Chapter 5 (Cornelis, R., Ed.), John Wiley & Sons, Inc., London, in press, 2004.
Byczkowski, J.Z.: In: U.S. Environmental Protection Agency (2002): Summary Report of the Technical Peer Review Workshop on the Draft Document Entitled A review of the Reference Dose and Reference Concentration Process. Risk Assessment Forum, U.S. EPA, Washington, DC, June 19, 2002, EPA/630/R-02/ August 7, 2002.
Byczkowski, J.Z., and Lipscomb, J.C.: Physiologically Based Pharmacokinetic Modeling of the Lactational Transfer of Methylmercury. Risk Anal. 21: 869-882, 2001.
Dorman, D.C., Allen, S.L., Byczkowski, J.Z., Claudio, L., Fisher, J.W., Harry, G.J., Li, A.A., Makris, S.L., Padilla, S., Sultatos, L.G., & Mileson, B.E.: Methods to Identify and Characterize Developmental Neurotoxicity for Human Health Risk Assessment: III. Pharmacokinetic and Pharmacodynamic Considerations. Environmental Health Perspectives. 109(suppl 1):101-111 (2001).
Lipscomb,J.C., Byczkowski,J.Z., and Harvey,T.: Physiologically based pharmacokinetic modeling of the lactational transfer of methylmercury. In: Metal Ions in Biolgy and Medicine (Centeno,J.A., Collery,P., Vernet,G., Finkelman,R.B., Gibb,H., Etienne,J.C., Eds.) Vol. 6, pp. 730-732, John Libbey Eurotext, Paris 2000.
Byczkowski,J.Z.: Pharmacokinetic/Dynamic Modeling. In: The Standard Handbook of Environmental Science, Health and Technology, Chapter 8.6 (Lehr,J., Ed), McGraw-Hill, New York, 2000.
Byczkowski,J.Z., Channel,S.R., & Miller,C.R.: A biologically based pharmacodynamic model for lipid peroxidation stimulated by trichloroethylene in vitro. J. Biochem. Mol. Toxicol. 13: 205-214, 1999.
Lipscomb,J.C., Fisher,J.W., Confer,P.D., & Byczkowski,J.Z.: In vitro to in vivo extrapolation for trichloroethylene metabolism in humans. Toxicol. Appl. Pharmacol. 152: 376-387, 1998.
Byczkowski,J.Z., & Kulkarni,A.P.: Oxidative stress and pro-oxidant biological effects of vanadium. In: Vanadium in the Environment. Part 2: Health Effects , Chapter 12 (Advances in Environmental Sciences and Technology, Nriagu,J.O. Ed), pp. 235 - 264 J.Wiley & Sons, New York, 1997.
Byczkowski,J.Z., Flemming,C.D., Curran,M.A., Miller,C.R., Schmidt,W.J., Moghaddam,A.P., Channel, S.R.: Physiologically based pharmacodynamic modeling of chemically induced oxidative stress. Technical Report AL/OE-TR-1997- 0130, 1997.
Byczkowski,J.Z., & Channel,S.R.: Chemically induced oxidative stress and tumorigenesis: effects on signal transduction and cell proliferation. Toxic Subst. Mechan. 15: 101-128, 1996.
Byczkowski,J.Z., Channel,S.R., Pravecek,T.L., & Miller,C.R.: Mathematical model for chemically induced lipid peroxidation in precision-cut liver slices: computer simulation and experimental calibration. Computer Meth. Progr. Biomed. 50: 73-84, 1996.
Yu,K.O., Tillitt,D.E., Byczkowski,J.Z., Burton Jr., G.A., Channel, S.R., Drerup, J.M., Flemming, C.D., & Fisher, J.: In vivo/in vitro comparison of the pharmacokinetics and pharmacodynamics of 3,3',4,4'-tetrachlorobiphenyl (PCB77). Toxicol. Appl. Pharmacol. 141: 434-438, 1996.
Byczkowski,J.Z.: Linked PBPK model and cancer risk assessment for breast fed infants. Drug Inf. J. 30: 401-412, 1996.
Byczkowski,J.Z., Seckel,C.S., Black,R.K., Creech,J.R. & Garrity,B.L.: Development and validation of a physiologically based pharmacokinetic model of chloral hydrate and its main metabolites. Technical Report AL/OE-TR-0178, 1995.
Byczkowski,J.Z., & Fisher,J.W.: A computer program linking physiologically based pharmacokinetic model with cancer risk assessment for breast fed infants. Computer Meth. Progr. Biomed. 46: 155-163, 1995.
Byczkowski,J.Z., Gearhart,J.M., & Fisher, J.W.:"Occupational" exposure of infants to toxic chemicals via breast milk. Nutrition 10: 43- 48, 1994.
Byczkowski,J.Z., & Fisher,J.W.: Lactational transfer of tetrachloroethylene in rats. Risk Analysis, 14: 339 -349, 1994.
Byczkowski,J.Z., Kinkead,E.R., Leahy,H.F., Randall,G.M., & J.W. Fisher: Computer simulation of lactational transfer of tetrachloroethylene in rats using a physiologically based model. Toxicol. Appl. Pharmacol., 125: 228 -236, 1994.
Joseph,P., Srinivasan,S.N., Byczkowski,J.Z. & Kulkarni,A.P.: Bioactivation of benzo(a)pyrene 7,8 dihydrodiol catalyzed by lipoxygenase purified from human term placenta and conceptal tissues. Reprod. Toxicol. 8: 307- 313, 1994.
Byczkowski,J.Z. & Kulkarni,A.P.: Oxidative stress and asbestos. In: Environmental Oxidants, Chapter 15 (Advances in Environmental Sciences and Technology, Nriagu, J.O., Ed), pp. 459 -474, J.Wiley & Sons, New York, 1994.
Kulkarni,A.P., & Byczkowski,J.Z.: Effects of transition metals on biological oxidations. In: Environmental Oxidants, Chapter 16 (Advances in Environmental Sciences and Technology, Nriagu,J.O. Ed), pp. 475- 496, J.Wiley & Sons, New York, 1994.
Barton, H.A., Byczkowski, J.Z., Channel, S.R., Jarnot, B.M., Lipscomb, J.C., & Williams, R.J.: Trichloroethylene: metabolism and other biological determinants of mouse liver tumors. Technical Report AL/OE TR 1994 -0135, 1994.
Williams,R.J., Creech,J.R., Black,R.K., Neurath,S.K., Jepson,G.W., & Byczkowski,J.Z.: Gas uptake kinetics of bromotrifluoromethane (Halon 1301) and its proposed replacement iodotrifluoromethane (CF3I). Technical Report AL/OE TR 1994- 0068, 1994.
Kulkarni,A.P., & Byczkowski,J.Z.: Hepatotoxicity. In: Introduction to Biochemical Toxicology, Chapter 20 (Hodgson,E., Levi,P.E., Ed.), pp. 459- 490, Appleton and Lange, Norwalk, CT, 1993.
Byczkowski,J.Z., & Kulkarni,A.P.: Linoleate dependent co oxygenation of benzo(a)pyrene and benzo(a)pyrene-7,8-dihydrodiol by rat cytosolic lipoxygenase. Xenobiotica 22: 609- 618, 1992.
Byczkowski,J.Z., & Kulkarni,A.P.: Vanadium redox cycling, lipid peroxidation and co- oxygenation of benzo(a)pyrene-7,8-dihydrodiol. Biochem. Biophys. Acta 1125: 134- 141, 1992.
Zychlinski,L., Byczkowski,J.Z. & Kulkarni, A.P.: Toxic Effects of Long Term Intratracheal Administration of Vanadium Pentoxide in Rats. Arch. Environ. Contam. Toxicol. 20: 295 -298, 1991.
Byczkowski,J.Z. & Kulkarni,A.P.: Lipid Peroxidation and Benzo(a)pyrene Derivative Co Oxygenation by Environmental Pollutants. Bull. Environ. Contam. Toxicol. 45: 633- 640, 1990.
Byczkowski,J.Z. & Kulkarni,A.P.: Lipid Peroxidation Coupled Co Oxygenation of Benzo(a)pyrene and Benzo(a)pyrene-7,8-dihydrodiol in Human Term Placental Microsomes. Placenta 11: 17- 26, 1990.
Zychlinski,L.& Byczkowski,J.Z.: Inhibitory Effects of Vanadium Pentoxide on Respiration of Rat Liver Mitochondria. Arch. Environ. Contam. Toxicol. 19: 138 -142, 1990.
Byczkowski,J.Z. & Kulkarni,A.P.: Lipoxygenase Catalyzed Epoxidation of Benzo(a)pyrene-7,8 -dihydrodiol. Biochem. Biophys. Res. Comm. 159: 1190 -1205, 1989.
Byczkowski,J.Z.& Kulkarni,A.P.: NADPH - dependent Drug Redox Cycling and Lipid Peroxidation in Microsomes from Human Term Placenta. Int. J. Biochem. 21: 183-190, 1989.
Byczkowski,J.Z., Wan,B.& Kulkarni,A.P.: Vanadium mediated Lipid Peroxidation in Microsomes from Human Term Placenta. Bull. Environ. Contam. Toxicol. 41: 696-703, 1988.
Gessner,T.& Byczkowski,J.Z.: A Simplified Method for Determination of Radioactive Metabolites of Benzo(a)pyrene Using HPLC with Radioactive Flow Detection. Progress HPLC. 3: 149-165, 1988.
Byczkowski,J.Z.& Gessner,T.: Biological Role of Superoxide Ion Radical. Minireview. Int. J. Biochem. 20: 569-580, 1988.
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Research at the American Museum of Natural History
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Bulletin of Environmental Contamination and Toxicology - Journal
Dr. Janusz Z. Byczkowski Homepage, complete list of Publications
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Chemicals in Environment Data base; ChemS - substructure search,
CIIT - Toxicology Home Page - The Hamner Institutes
National Library of Medicine's Toxic Chemicals data base TOXNET
Carcinogenic Chemicals Potency data base
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Environmental Chemicals; Reference Toxicity Values - EPA's IRIS Page
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Drug Toxicity - Poison Control Centers
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Hazardous Substances Data Bank
Introduction to hormone disrupting chemicals
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Inhalation Toxicology, Journal
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Lactational Transfer of Drugs and Toxic Chemicals
Lactational transfer of Chemicals and Drugs - data base
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PHARMACOKINETICS/PHARMACODYNAMICS:
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PK Solutions 2.0 - Noncompartmental Pharmacokinetic Equations
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Cumulative Index to Risk, Journal on-line
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